MAT a Synced to SGD on Fri Aug 1 09:00:52 2008 plate row column ORF Gene Alias Description GO Aspect GO Term Notes 1 A 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 2 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 3 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 4 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 5 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 6 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 7 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 8 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 9 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 10 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 11 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 12 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 13 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 14 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 15 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 16 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 17 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 18 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 19 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 20 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 21 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 22 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 23 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 A 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 B 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 B 2 YBR030W - - Putative protein of unknown function; predicted protein contains a SET domain (S-adenosyl-L-methionine-binding fold) C, F, P lipid metabolic process, molecular_function, nucleus - 1 B 3 YBR138C - HDR1 Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function - 1 B 4 YBR028C - - Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA) C, F, P biological_process, cytoplasm, protein kinase activity - 1 B 5 YBR137W - - Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); YBR137W is not an essential gene C, F, P biological_process, cytoplasm, molecular_function - 1 B 6 YBR027C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function - 1 B 7 YBR134W - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function - 1 B 8 YBR026C ETR1 MRF1'|MRF1 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis C, F, P cellular respiration, generation of precursor metabolites and energy, lipid metabolic process, mitochondrion, oxidoreductase activity - 1 B 9 YBR132C AGP2 - High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, lipid metabolic process, membrane, plasma membrane, response to stress, transport, transporter activity, vacuole petite 1 B 10 YBR025C OLA1 - P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide C, F, P biological_process, cytoplasm, hydrolase activity - 1 B 11 YBR131W CCZ1 CVT16 Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway C, F, P cytoplasm, enzyme regulator activity, membrane, membrane organization and biogenesis, organelle organization and biogenesis, other, response to stress, transport, vesicle-mediated transport - 1 B 12 YBR024W SCO2 - Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p C, F, P mitochondrial envelope, mitochondrion, oxidoreductase activity, transport - 1 B 13 YBR130C SHE3 - Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance C, F, P DNA metabolic process, RNA binding, cell cortex, cellular bud, cytoplasm, cytoskeleton, organelle organization and biogenesis, other, site of polarized growth - 1 B 14 YBR023C CHS3 KTI2|DIT101|CSD2|CAL1 Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan C, F, P carbohydrate metabolic process, cell wall organization and biogenesis, cellular bud, cytokinesis, cytoplasm, cytoplasmic membrane-bounded vesicle, membrane, other, site of polarized growth, sporulation, transferase activity - 1 B 15 YBR129C OPY1 - Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P conjugation, cytoplasm, mitochondrion, molecular_function - 1 B 16 YBR022W POA1 - Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing C, F, P RNA metabolic process, cellular_component, hydrolase activity - 1 B 17 YBR128C ATG14 APG14|CVT12 Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34p, Vps15p, and Vps30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS C, F, P cytoplasm, membrane, membrane fraction, protein catabolic process, response to stress, transferase activity, vacuole - 1 B 18 YBR020W GAL1 - Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p C, F, P RNA metabolic process, carbohydrate metabolic process, cytoplasm, response to chemical stimulus, transcription, transferase activity, transport - 1 B 19 YBR126C TPS1 TSS1|GLC6|GGS1|FDP1|CIF1|BYP1 Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway C, F, P carbohydrate metabolic process, cytoplasm, response to chemical stimulus, response to stress, transferase activity - 1 B 20 YBR019C GAL10 - UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers C, F, P carbohydrate metabolic process, isomerase activity, other - 1 B 21 YBR125C PTC4 GCT1 Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity C, F, P biological_process, cytoplasm, hydrolase activity, phosphoprotein phosphatase activity - 1 B 22 YBR018C GAL7 - Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism C, F, P carbohydrate metabolic process, cytoplasm, nucleotidyltransferase activity, transferase activity - 1 B 23 YBR122C MRPL36 - Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation petite 1 B 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 C 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 C 2 YAL017W PSK1 FUN31 One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status C, F, P carbohydrate metabolic process, cell wall organization and biogenesis, cytoplasm, protein kinase activity, protein modification process, transferase activity - 1 C 3 YBL032W HEK2 KHD1 RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length C, F, P DNA metabolic process, RNA binding, chromosome, cytoplasm, nucleus, organelle organization and biogenesis, other - 1 C 4 YAL015C NTG1 SCR1|FUN33 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion C, F, P DNA metabolic process, hydrolase activity, lyase activity, mitochondrion, nucleus, response to stress - 1 C 5 YBL031W SHE1 - Cytoskeletal protein of unknown function; overexpression causes growth arrest C, F, P biological_process, cytoskeleton, molecular_function - 1 C 6 YAL014C SYN8 SLT2|UIP2 Endosomal SNARE related to mammalian syntaxin 8 C, F, P cytoplasm, protein binding, transport - 1 C 7 YBL029W - - Non-essential protein of unknown function C, F, P biological_process, cytoplasm, molecular_function, nucleus - 1 C 8 YAL013W DEP1 FUN54 Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation C, F, P RNA metabolic process, hydrolase activity, lipid metabolic process, nucleus, organelle organization and biogenesis, protein modification process, transcription, transcription regulator activity - 1 C 9 YBL028C - - Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis C, F, P molecular_function, nucleolus, nucleus, ribosome, ribosome biogenesis - 1 C 10 YAL011W SWC3 SWC1 Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae C, F, P mitochondrion, molecular_function, nucleus, organelle organization and biogenesis, response to chemical stimulus - 1 C 11 YBL027W RPL19B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal C, F, P cytoplasm, ribosome, structural molecule activity, translation - 1 C 12 YAL010C MDM10 FUN37 Subunit of both the Mdm10-Mdm12-Mmm1 complex and the mitochondrial sorting and assembly machinery (SAM complex); functions in both the general and Tom40p-specific pathways for import and assembly of outer membrane beta-barrel proteins C, F, P cytoplasm, membrane, membrane organization and biogenesis, mitochondrial envelope, mitochondrion, molecular_function, organelle organization and biogenesis, other, transport - 1 C 13 YBL025W RRN10 - Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I C, F, P DNA binding, RNA metabolic process, nucleolus, nucleus, transcription, transcription regulator activity slow growing 1 C 14 YAL008W FUN14 - Mitochondrial protein of unknown function C, F, P biological_process, cytoplasm, membrane, mitochondrial envelope, mitochondrion, molecular_function - 1 C 15 YBL024W NCL1 TRM4 S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120 C, F, P RNA metabolic process, nucleus, ribosome biogenesis, transferase activity - 1 C 16 YAL007C ERP2 - Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function, transport, vesicle-mediated transport - 1 C 17 YBL021C HAP3 - Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding C, F, P carbohydrate metabolic process, nucleus, transcription, transcription regulator activity petite 1 C 18 YAL005C SSA1 YG100 ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall C, F, P cell wall, cytoplasm, hydrolase activity, membrane, nucleus, organelle organization and biogenesis, protein binding, protein folding, response to stress, translation, transport, vacuole - 1 C 19 YBL019W APN2 ETH1 Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII C, F, P DNA metabolic process, hydrolase activity, lyase activity, nucleus, response to stress - 1 C 20 YAL004W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C C, F, P biological_process, cellular_component, molecular_function - 1 C 21 YBL017C PEP1 VPT1|VPS10 Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments C, F, P Golgi apparatus, other, protein catabolic process, transport - 1 C 22 YAL002W VPS8 VPT8|FUN15 Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif C, F, P cytoplasm, membrane fraction, molecular_function, transport, vesicle-mediated transport - 1 C 23 YBL016W FUS3 DAC2 Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation C, F, P cell cycle, conjugation, cytoplasm, mitochondrion, nucleus, other, protein kinase activity, protein modification process, response to chemical stimulus, signal transducer activity, signal transduction, site of polarized growth, transferase activity Sterile 1 C 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 D 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 D 2 YBR045C GIP1 - Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p C, F, P cell wall organization and biogenesis, cytoplasm, enzyme regulator activity, membrane, other, protein binding, sporulation - 1 D 3 YBR156C SLI15 - Subunit of the Ipl1p-Sli15p-Bir1p complex that regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; regulates the activity and localization of the Ipl1p aurora kinase C, F, P cytokinesis, cytoskeleton, enzyme regulator activity, other, protein modification process - 1 D 4 YBR044C TCM62 - Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone C, F, P cytoplasm, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, protein binding - 1 D 5 YBR151W APD1 - Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus C, F, P biological_process, cytoplasm, molecular_function, nucleus - 1 D 6 YBR043C QDR3 AQR2 Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin C, F, P plasma membrane, response to chemical stimulus, transport, transporter activity - 1 D 7 YBR150C TBS1 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, cytoplasm, mitochondrion, molecular_function, nucleus - 1 D 8 YBR042C CST26 - Protein of unknown function, affects chromosome stability when overexpressed C, F, P cytoplasm, lipid metabolic process, transferase activity - 1 D 9 YBR149W ARA1 - NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product C, F, P carbohydrate metabolic process, cytoplasm, oxidoreductase activity - 1 D 10 YBR041W FAT1 - Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids C, F, P cytoplasm, ligase activity, lipid metabolic process, membrane, membrane fraction, peroxisome, plasma membrane, transport, transporter activity - 1 D 11 YBR148W YSW1 - Protein expressed specifically in spores C, F, P biological_process, cellular_component, molecular_function - 1 D 12 YBR040W FIG1 - Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating C, F, P anatomical structure morphogenesis, cell wall, conjugation, molecular_function, response to chemical stimulus, site of polarized growth - 1 D 13 YBR147W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity C, F, P biological_process, mitochondrion, molecular_function - 1 D 14 YBR036C CSG2 CLS2 Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations C, F, P cellular homeostasis, cytoplasm, endomembrane system, endoplasmic reticulum, enzyme regulator activity, lipid metabolic process, membrane, response to chemical stimulus - 1 D 15 YBR146W MRPS9 - Mitochondrial ribosomal protein of the small subunit C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation - 1 D 16 YBR034C HMT1 RMT1|ODP1|HCP1 Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; required for viability of npl3 mutants C, F, P nucleus, protein modification process, ribosome biogenesis, transferase activity, transport - 1 D 17 YBR145W ADH5 - Alcohol dehydrogenase isoenzyme V; involved in ethanol production C, F, P amino acid and derivative metabolic process, cofactor metabolic process, cytoplasm, generation of precursor metabolites and energy, nucleus, oxidoreductase activity, vitamin metabolic process - 1 D 18 YBR033W EDS1 - Putative zinc cluster protein; YBR033W is not an essential gene C, F, P biological_process, cellular_component, molecular_function - 1 D 19 YBR144C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene C, F, P biological_process, cellular_component, molecular_function - 1 D 20 YBR032W - - Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function - 1 D 21 YBR141C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene C, F, P biological_process, molecular_function, nucleolus - 1 D 22 YBR031W RPL4A - N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins C, F, P cytoplasm, ribosome, structural molecule activity, translation - 1 D 23 YBR139W - - Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner C, F, P cytoplasm, hydrolase activity, other, peptidase activity, vacuole - 1 D 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 E 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 E 2 YAL031C GIP4 FUN21 Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate C, F, P cytoplasm, enzyme regulator activity, other, protein binding - 1 E 3 YBL052C SAS3 - Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality C, F, P RNA metabolic process, nucleus, organelle organization and biogenesis, protein modification process, transcription, transferase activity - 1 E 4 YAL030W SNC1 - Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, membrane, membrane organization and biogenesis, organelle organization and biogenesis, protein binding, transport, vesicle-mediated transport - 1 E 5 YBL051C PIN4 MDT1 Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage C, F, P cell cycle, cytoplasm, molecular_function, response to stress, signal transduction - 1 E 6 YAL029C MYO4 SHE1|FUN22 One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p C, F, P DNA metabolic process, cellular bud, cytoskeleton, mitochondrion, motor activity, organelle organization and biogenesis, other, protein binding - 1 E 7 YBL049W MOH1 - Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase C, F, P biological_process, cellular_component, molecular_function - 1 E 8 YAL028W FRT2 HPH2 Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate C, F, P endoplasmic reticulum, molecular_function, response to stress - 1 E 9 YBL048W - - Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function - 1 E 10 YAL027W SAW1 - Catalyzes 3'-nonhomologous tail removal of Rad1p/Rad10p-dependent single-strand annealing recombination intermediates; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene C, F, P biological_process, molecular_function, nucleus - 1 E 11 YBL047C EDE1 BUD15 Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins C, F, P cell cortex, cellular bud, cytoplasm, cytoskeleton, membrane organization and biogenesis, protein binding, response to chemical stimulus, response to stress, signal transduction, site of polarized growth, transport, vesicle-mediated transport - 1 E 12 YAL026C DRS2 SWA3|FUN38 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease C, F, P Golgi apparatus, cytoplasm, hydrolase activity, membrane organization and biogenesis, organelle organization and biogenesis, ribosome biogenesis, transport, transporter activity, vesicle-mediated transport - 1 E 13 YBL046W PSY4 - Putative regulatory subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and a third subunit Psy2p; required for cisplatin resistance; GFP-fusion protein localizes to the nucleus C, F, P enzyme regulator activity, nucleus, protein modification process, response to chemical stimulus - 1 E 14 YAL023C PMT2 FUN25 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals C, F, P endoplasmic reticulum, protein modification process, transferase activity - 1 E 15 YBL043W ECM13 - Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation C, F, P cell wall organization and biogenesis, cellular_component, molecular_function - 1 E 16 YAL022C FUN26 - Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes C, F, P membrane, other, transport, transporter activity - 1 E 17 YBL042C FUI1 - High affinity uridine permease, localized to the plasma membrane; not involved in uracil transport C, F, P plasma membrane, transport, transporter activity - 1 E 18 YAL020C ATS1 KTI13|FUN28 Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle C, F, P RNA metabolic process, cell budding, cytoplasm, cytoskeleton organization and biogenesis, molecular_function, organelle organization and biogenesis - 1 E 19 YBL039C URA7 - Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis C, F, P aromatic compound metabolic process, cytoplasm, heterocycle metabolic process, ligase activity, lipid metabolic process, other - 1 E 20 YAL019W FUN30 - Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P mitochondrion, molecular_function, nucleus, organelle organization and biogenesis - 1 E 21 YBL037W APL3 - Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport C, F, P cytoplasm, cytoplasmic membrane-bounded vesicle, endomembrane system, membrane, molecular_function, plasma membrane, vesicle-mediated transport - 1 E 22 YAL018C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function - 1 E 23 YBL036C - - Single-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS C, F, P amino acid and derivative metabolic process, isomerase activity, other - 1 E 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 F 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 F 2 YBR058C UBP14 GID6 Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T C, F, P carbohydrate metabolic process, cytoplasm, hydrolase activity, peptidase activity, protein catabolic process, protein modification process, response to chemical stimulus - 1 F 3 YBR169C SSE2 - Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p C, F, P cytoplasm, other, protein folding - 1 F 4 YBR057C MUM2 SPOT8 Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex C, F, P DNA metabolic process, cytoplasm, molecular_function - 1 F 5 YBR168W PEX32 - Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p C, F, P cytoplasm, membrane, molecular_function, organelle organization and biogenesis, peroxisome - 1 F 6 YBR056W - - Putative cytoplasmic protein of unknown function C, F, P biological_process, cytoplasm, molecular_function - 1 F 7 YBR166C TYR1 - Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels C, F, P amino acid and derivative metabolic process, aromatic compound metabolic process, cytoplasm, oxidoreductase activity - 1 F 8 YBR054W YRO2 - Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p C, F, P biological_process, cellular bud, mitochondrion, molecular_function - 1 F 9 YBR165W UBS1 - Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity C, F, P molecular_function, nucleus, protein modification process, transport - 1 F 10 YBR053C - - Putative protein of unknown function; induced by cell wall perturbation C, F, P biological_process, cellular_component, molecular_function - 1 F 11 YBR164C ARL1 DLP2 Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor C, F, P Golgi apparatus, hydrolase activity, other, transport, vesicle-mediated transport - 1 F 12 YBR052C RFS1 - Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern C, F, P biological_process, cytoplasm, molecular_function - 1 F 13 YBR162W-A YSY6 - Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion C, F, P endoplasmic reticulum, molecular_function, transport - 1 F 14 YBR051W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase C, F, P biological_process, cellular_component, molecular_function - 1 F 15 YBR162C TOS1 - Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C C, F, P cell wall, cytoplasm, molecular_function, response to chemical stimulus, vacuole - 1 F 16 YBR050C REG2 - Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease C, F, P RNA metabolic process, cytoplasm, enzyme regulator activity, transcription - 1 F 17 YBR161W CSH1 - Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p C, F, P cytoplasm, lipid metabolic process, transferase activity, vacuole - 1 F 18 YBR048W RPS11B - Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins C, F, P cytoplasm, nucleolus, nucleus, organelle organization and biogenesis, ribosome, ribosome biogenesis, structural molecule activity, translation - 1 F 19 YBR159W - - Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides C, F, P endoplasmic reticulum, lipid metabolic process, membrane, oxidoreductase activity - 1 F 20 YBR047W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function - 1 F 21 YBR158W AMN1 CST13|ICS4 Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) C, F, P cell cycle, cellular bud, cytoplasm, nucleus, protein binding - 1 F 22 YBR046C ZTA1 - Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity C, F, P RNA binding, cytoplasm, nucleus, oxidoreductase activity, response to chemical stimulus, response to stress - 1 F 23 YBR157C ICS2 - Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization C, F, P biological_process, cellular_component, molecular_function - 1 F 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 G 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 G 2 YAL054C ACS1 FUN44 Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions C, F, P cofactor metabolic process, cytoplasm, generation of precursor metabolites and energy, ligase activity, mitochondrion, organelle organization and biogenesis, protein modification process - 1 G 3 YBL064C PRX1 - Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated C, F, P cellular homeostasis, mitochondrion, oxidoreductase activity, response to chemical stimulus, response to stress - 1 G 4 YAL053W FLC2 HUF2 Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance C, F, P cell wall organization and biogenesis, cytoplasm, endoplasmic reticulum, protein folding, transport, transporter activity - 1 G 5 YBL063W KIP1 CIN9 Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p C, F, P cell cycle, cytoplasm, cytoskeleton, cytoskeleton organization and biogenesis, microtubule organizing center, motor activity, organelle organization and biogenesis, structural molecule activity - 1 G 6 YAL051W OAF1 YAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis C, F, P DNA binding, lipid metabolic process, nucleus, organelle organization and biogenesis, response to chemical stimulus, transcription, transcription regulator activity - 1 G 7 YBL062W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function - 1 G 8 YAL049C - - Cytoplasmic protein of unknown function, potential Hsp82p interactor; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) C, F, P biological_process, cytoplasm, molecular_function - 1 G 9 YBL061C SKT5 CSD4|CHS4|CAL2 Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation C, F, P carbohydrate metabolic process, cell cortex, cell wall organization and biogenesis, cellular bud, cytokinesis, cytoplasm, cytoskeleton, enzyme regulator activity, other, response to stress, site of polarized growth - 1 G 10 YAL045C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A C, F, P biological_process, cellular_component, molecular_function - 1 G 11 YBL060W YEL1 - Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip C, F, P cellular bud, cytoplasm, enzyme regulator activity, other, site of polarized growth - 1 G 12 YAL043C-A - - - - - - 1 G 13 YBL059W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function - 1 G 14 YAL042W ERV46 FUN9 Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, endomembrane system, endoplasmic reticulum, membrane, molecular_function, transport, vesicle-mediated transport - 1 G 15 YBL057C PTH2 - One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth C, F, P cytoplasm, hydrolase activity, membrane, mitochondrial envelope, mitochondrion, protein catabolic process, translation - 1 G 16 YAL040C CLN3 WHI1|FUN10|DAF1 G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis C, F, P cell cycle, enzyme regulator activity, membrane organization and biogenesis, nucleus, organelle organization and biogenesis, other - 1 G 17 YBL056W PTC3 - Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation C, F, P cell cycle, cytoplasm, hydrolase activity, nucleus, phosphoprotein phosphatase activity, protein modification process, response to stress, signal transduction - 1 G 18 YAL037W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function - 1 G 19 YBL055C - Tat-D 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases C, F, P DNA metabolic process, cytoplasm, hydrolase activity, nuclear organization and biogenesis, organelle organization and biogenesis, response to chemical stimulus, response to stress, signal transduction - 1 G 20 YAL036C RBG1 FUN11 Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46p C, F, P cytoplasm, other, ribosome biogenesis - 1 G 21 YBL054W - - Protein of unknown function involved in rRNA and ribosome biosynthesis C, F, P cytoplasm, molecular_function, nucleus, ribosome biogenesis - 1 G 22 YAL034C FUN19 - Non-essential protein of unknown function C, F, P biological_process, cellular_component, molecular_function - 1 G 23 YBL053W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function - 1 G 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 H 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 H 2 YBR071W - - Putative protein of unknown function; (GFP)-fusion and epitope-tagged proteins localize to the cytoplasm; mRNA expression may be regulated by the cell cycle and/or cell wall stress C, F, P biological_process, cytoplasm, molecular_function - 1 H 3 YBR182C SMP1 - Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors C, F, P DNA binding, RNA metabolic process, cytoplasm, nucleus, response to stress, transcription, transcription regulator activity - 1 H 4 YBR069C TAT1 VAP1|TAP1 Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance C, F, P plasma membrane, transport, transporter activity - 1 H 5 YBR181C RPS6B RPS102|RPS101|LPG18 Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein C, F, P cytoplasm, nucleolus, nucleus, ribosome, structural molecule activity, translation - 1 H 6 YBR068C BAP2 - High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains C, F, P plasma membrane, transport, transporter activity - 1 H 7 YBR180W DTR1 - Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters C, F, P cell wall organization and biogenesis, membrane, sporulation, transport, transporter activity - 1 H 8 YBR067C TIP1 - Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins C, F, P cell wall, cell wall organization and biogenesis, hydrolase activity, structural molecule activity - 1 H 9 YBR178W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C C, F, P biological_process, cellular_component, molecular_function - 1 H 10 YBR066C NRG2 - Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p C, F, P nucleus, other, pseudohyphal growth, transcription regulator activity - 1 H 11 YBR177C EHT1 - Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane C, F, P cytoplasm, hydrolase activity, lipid metabolic process, membrane, mitochondrial envelope, mitochondrion, transferase activity - 1 H 12 YBR065C ECM2 SLT11 Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p C, F, P RNA metabolic process, cell wall organization and biogenesis, molecular_function, nucleus - 1 H 13 YBR176W ECM31 - Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate C, F, P cofactor metabolic process, mitochondrion, transferase activity - 1 H 14 YBR064W - - Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C C, F, P biological_process, cellular_component, molecular_function - 1 H 15 YBR175W SWD3 SAF35|CPS30 Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 C, F, P RNA metabolic process, nucleus, organelle organization and biogenesis, protein modification process, transcription, transferase activity - 1 H 16 YBR063C - - Putative protein of unknown function; YBR063C is not an essential gene C, F, P biological_process, cellular_component, molecular_function - 1 H 17 YBR174C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective C, F, P biological_process, cellular_component, molecular_function - 1 H 18 YBR062C - - Hypothetical protein C, F, P biological_process, cellular_component, molecular_function - 1 H 19 YBR172C SMY2 - Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; has similarity to S. pombe Mpd2 C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, molecular_function, transport, vesicle-mediated transport - 1 H 20 YBR061C TRM7 - 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop C, F, P RNA metabolic process, cytoplasm, transferase activity, translation - 1 H 21 YBR171W SEC66 SEC71|HSS1 Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, other, transport, transporter activity - 1 H 22 YBR059C AKL1 - Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization C, F, P cellular bud, cytoplasm, cytoskeleton organization and biogenesis, membrane organization and biogenesis, organelle organization and biogenesis, protein kinase activity, site of polarized growth, transport, vesicle-mediated transport - 1 H 23 YBR170C NPL4 HRD4 Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, molecular_function, protein catabolic process - 1 H 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 I 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 I 2 YAL066W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function - 1 I 3 YBL079W NUP170 NLE3 Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation, has similarity to Nup157p C, F, P endomembrane system, membrane, nuclear organization and biogenesis, nucleus, organelle organization and biogenesis, other, structural molecule activity, transport - 1 I 4 YAL065C - - Putative protein of unknown function; has homology to FLO1; possible pseudogene C, F, P biological_process, cellular_component, molecular_function - 1 I 5 YBL078C ATG8 AUT7|CVT5|APG8 Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation C, F, P cytoplasm, membrane, membrane organization and biogenesis, molecular_function, organelle organization and biogenesis, response to stress, transport, vacuole, vesicle-mediated transport - 1 I 6 YAL064C-A - YAL065C-A Putative protein of unknown function; YAL064C-A is not an essential gene C, F, P biological_process, cellular_component, molecular_function - 1 I 7 YBL075C SSA3 YG106 ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm C, F, P cytoplasm, hydrolase activity, protein binding, protein folding, response to stress, transport - 1 I 8 YAL062W GDH3 FUN51 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources C, F, P amino acid and derivative metabolic process, mitochondrion, nucleus, other, oxidoreductase activity - 1 I 9 YBL072C RPS8A - Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein C, F, P cytoplasm, nucleolus, nucleus, ribosome, structural molecule activity, translation - 1 I 10 YAL061W BDH2 - Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene C, F, P biological_process, cytoplasm, nucleus, oxidoreductase activity - 1 I 11 YBL071C - - Dubious open reading frame, predicted protein contains a peroxisomal targeting signal C, F, P biological_process, cellular_component, molecular_function - 1 I 12 YAL060W BDH1 - NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source C, F, P cytoplasm, other, oxidoreductase activity - 1 I 13 YBL070C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function - 1 I 14 YAL059W ECM1 - Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export C, F, P cell wall organization and biogenesis, molecular_function, nucleolus, nucleus, organelle organization and biogenesis, ribosome biogenesis, transport - 1 I 15 YBL069W AST1 - Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts C, F, P membrane, molecular_function, transport - 1 I 16 YAL058W CNE1 FUN48 Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, protein binding, protein catabolic process, protein folding - 1 I 17 YBL068W PRS4 - 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes C, F, P carbohydrate metabolic process, cell wall organization and biogenesis, cytoplasm, ribosome biogenesis, transferase activity - 1 I 18 YAL058C-A - - - - - - 1 I 19 YBL067C UBP13 - Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions C, F, P biological_process, cellular_component, hydrolase activity, peptidase activity - 1 I 20 YAL056W GPB2 KRH1 Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p C, F, P RNA metabolic process, cytoplasm, enzyme regulator activity, mitochondrion, other, plasma membrane, protein binding, pseudohyphal growth, response to chemical stimulus, signal transducer activity, signal transduction, sporulation, transcription - 1 I 21 YBL066C SEF1 - Putative transcription factor, has homolog in Kluyveromyces lactis C, F, P biological_process, cellular_component, molecular_function - 1 I 22 YAL055W PEX22 YAF5 Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation C, F, P cytoplasm, membrane, organelle organization and biogenesis, peroxisome, protein binding, signal transduction, transport - 1 I 23 YBL065W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene C, F, P biological_process, cellular_component, molecular_function - 1 I 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 J 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 J 2 YBR090C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus C, F, P biological_process, cytoplasm, molecular_function, nucleus - 1 J 3 YBR199W KTR4 - Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family C, F, P Golgi apparatus, protein modification process, transferase activity - 1 J 4 YBR084W MIS1 - Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase C, F, P RNA metabolic process, aromatic compound metabolic process, cofactor metabolic process, heterocycle metabolic process, hydrolase activity, ligase activity, mitochondrion, other, oxidoreductase activity, protein modification process, ribosome biogenesis, translation, vitamin metabolic process - 1 J 5 YBR197C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus - 1 J 6 YBR084C-A RPL19A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal C, F, P cytoplasm, ribosome, structural molecule activity, translation - 1 J 7 YBR195C MSI1 CAC3 Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46 C, F, P DNA metabolic process, RNA metabolic process, nucleus, organelle organization and biogenesis, response to stress, signal transduction, transcription, transcription regulator activity - 1 J 8 YBR083W TEC1 ROC1 Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member C, F, P RNA metabolic process, nucleus, other, pseudohyphal growth, transcription, transcription regulator activity - 1 J 9 YBR194W - SOY1 Protein proposed to be associated with the nuclear pore complex; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and a severe growth defect in minimal glycerol media C, F, P biological_process, cytoplasm, molecular_function - 1 J 10 YBR082C UBC4 - Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response C, F, P ligase activity, other, protein catabolic process, protein modification process, response to stress, sporulation - 1 J 11 YBR189W RPS9B SUP46|RPS13A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins C, F, P cytoplasm, nucleolus, nucleus, ribosome, structural molecule activity, translation - 1 J 12 YBR077C SLM4 GSE1|NIR1|EGO3 Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 C, F, P cytoplasm, lipid binding, membrane, membrane organization and biogenesis, response to chemical stimulus, signal transduction, vacuole - 1 J 13 YBR188C NTC20 - Member of a complex, including Prp19p, that binds to the spliceosome; required for pre-mRNA splicing C, F, P RNA metabolic process, nucleus, other - 1 J 14 YBR076W ECM8 - Non-essential protein of unknown function C, F, P cell wall organization and biogenesis, cellular_component, molecular_function - 1 J 15 YBR187W GDT1 - Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis C, F, P cytoplasm, molecular_function, ribosome biogenesis, vacuole - 1 J 16 YBR075W - - - - - - 1 J 17 YBR186W PCH2 - Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA C, F, P cell cycle, meiosis, molecular_function, nucleolus - 1 J 18 YBR074W - YBR075W Putative metalloprotease C, F, P biological_process, cellular_component, molecular_function - 1 J 19 YBR185C MBA1 - Protein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane C, F, P cellular respiration, cytoplasm, generation of precursor metabolites and energy, membrane, membrane organization and biogenesis, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, other - 1 J 20 YBR073W RDH54 TID1 DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference C, F, P DNA binding, DNA metabolic process, cell cycle, hydrolase activity, meiosis, nucleus, organelle organization and biogenesis, response to stress - 1 J 21 YBR184W - - Putative protein of unknown function; YBR184W is not an essential gene C, F, P biological_process, cellular_component, molecular_function - 1 J 22 YBR072W HSP26 - Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells C, F, P cytoplasm, nucleus, protein binding, protein folding, response to stress - 1 J 23 YBR183W YPC1 - Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance C, F, P endoplasmic reticulum, hydrolase activity, lipid metabolic process - 1 J 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 K 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 K 2 YAR027W UIP3 - Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family C, F, P biological_process, endomembrane system, molecular_function, nucleus - 1 K 3 YBL094C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W C, F, P biological_process, cellular_component, molecular_function - 1 K 4 YAR023C - - Putative integral membrane protein, member of DUP240 gene family C, F, P biological_process, cellular_component, molecular_function - 1 K 5 YBL091C-A SCS22 - Protein involved in regulation of phospholipid metabolism; homolog of Scs2p; similar to D. melanogaster inturned protein C, F, P cellular_component, lipid metabolic process, molecular_function - 1 K 6 YAR020C PAU7 - Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme C, F, P biological_process, cellular_component, molecular_function - 1 K 7 YBL091C MAP2 - Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p C, F, P cytoplasm, hydrolase activity, other, peptidase activity - 1 K 8 YAR018C KIN3 NPK1|FUN52 Nonessential protein kinase with unknown cellular role C, F, P cellular_component, other, protein kinase activity - 1 K 9 YBL089W AVT5 - Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters C, F, P cellular_component, transport, transporter activity - 1 K 10 YAR015W ADE1 - N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine C, F, P cytoplasm, ligase activity, nucleus, other, response to chemical stimulus Ade- 1 K 11 YBL088C TEL1 - Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene C, F, P DNA binding, DNA metabolic process, mitochondrion, nucleus, organelle organization and biogenesis, other, protein kinase activity, protein modification process, response to stress - 1 K 12 YAR014C BUD14 - Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern C, F, P RNA metabolic process, anatomical structure morphogenesis, cellular bud, cytoskeleton organization and biogenesis, enzyme regulator activity, other, site of polarized growth, transcription - 1 K 13 YBL087C RPL23A - Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins C, F, P cytoplasm, ribosome, structural molecule activity, translation - 1 K 14 YAR003W SWD1 SAF49|CPS50|FUN16 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 C, F, P RNA metabolic process, nucleus, organelle organization and biogenesis, protein modification process, transcription, transferase activity - 1 K 15 YBL086C - - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery C, F, P biological_process, cellular_component, molecular_function - 1 K 16 YAR002W NUP60 - Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance C, F, P endomembrane system, membrane, nucleus, structural molecule activity, transport - 1 K 17 YBL085W BOI1 BOB1|GIN7 Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain C, F, P anatomical structure morphogenesis, cell budding, cellular bud, cytokinesis, lipid binding, signal transduction, site of polarized growth - 1 K 18 YAR002C-A ERP1 - Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, mitochondrion, molecular_function, transport, vesicle-mediated transport - 1 K 19 YBL083C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3 C, F, P biological_process, cellular_component, molecular_function - 1 K 20 YAL068C - - Hypothetical protein C, F, P RNA metabolic process, cellular_component, molecular_function, sporulation, transcription - 1 K 21 YBL082C ALG3 RHK1 Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins C, F, P carbohydrate metabolic process, endoplasmic reticulum, lipid metabolic process, protein modification process, transferase activity - 1 K 22 YAL067C SEO1 - Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide C, F, P membrane, transport, transporter activity - 1 K 23 YBL081W - - Non-essential protein of unknown function C, F, P biological_process, cellular_component, molecular_function - 1 K 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 L 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 L 2 YBR104W YMC2 - Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p C, F, P mitochondrion, organelle organization and biogenesis, transport, transporter activity - 1 L 3 YBR212W NGR1 RBP1 RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase C, F, P DNA binding, RNA binding, cytoplasm, organelle organization and biogenesis, other, translation regulator activity - 1 L 4 YBR103W SIF2 EMB1 WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus C, F, P RNA metabolic process, cell cycle, hydrolase activity, meiosis, nucleus, organelle organization and biogenesis, protein binding, protein modification process, transcription, transcription regulator activity - 1 L 5 YBR210W ERV15 - Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p C, F, P Golgi apparatus, anatomical structure morphogenesis, cell budding, cytokinesis, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function, transport, vesicle-mediated transport - 1 L 6 YBR101C FES1 - Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum C, F, P cytoplasm, other, ribosome, translation - 1 L 7 YBR209W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene C, F, P biological_process, cellular_component, molecular_function Lys- 1 L 8 YBR100W - - - - - - 1 L 9 YBR208C DUR1,2 DUR80 Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation C, F, P cytoplasm, heterocycle metabolic process, hydrolase activity, ligase activity, other - 1 L 10 YBR099C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4 C, F, P biological_process, cellular_component, molecular_function - 1 L 11 YBR207W FTH1 - Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis C, F, P cytoplasm, membrane, membrane organization and biogenesis, transport, transporter activity, vacuole, vesicle-mediated transport - 1 L 12 YBR098W MMS4 YBR100W|SLX2 Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination and DNA repair C, F, P DNA metabolic process, cell cycle, hydrolase activity, meiosis, nucleus, other, protein binding, response to stress, transcription regulator activity - 1 L 13 YBR206W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 C, F, P biological_process, cellular_component, molecular_function - 1 L 14 YBR095C RXT2 RAF60 Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth C, F, P RNA metabolic process, conjugation, hydrolase activity, nucleus, organelle organization and biogenesis, other, protein modification process, transcription - 1 L 15 YBR205W KTR3 - Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family C, F, P cell wall organization and biogenesis, membrane fraction, protein modification process, transferase activity - 1 L 16 YBR094W PBY1 - Putative tubulin tyrosine ligase associated with P-bodies C, F, P biological_process, cytoplasm, molecular_function - 1 L 17 YBR204C - - Serine hydrolase; YBR204C is not an essential gene C, F, P biological_process, cellular_component, hydrolase activity - 1 L 18 YBR093C PHO5 phoE Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 C, F, P cell wall, hydrolase activity, other, response to stress - 1 L 19 YBR203W COS111 - Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P mitochondrion, molecular_function, signal transduction - 1 L 20 YBR092C PHO3 phoC Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin C, F, P hydrolase activity, other, vitamin metabolic process - 1 L 21 YBR201W DER1 - Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, protein binding, protein catabolic process - 1 L 22 YBR090C-A - - - - - - 1 L 23 YBR200W BEM1 SRO1 Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p C, F, P anatomical structure morphogenesis, cellular bud, conjugation, lipid binding, other, protein binding, response to chemical stimulus, site of polarized growth - 1 L 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 M 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 M 2 YAR047C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function - 1 M 3 YBR001C NTH2 - Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses C, F, P carbohydrate metabolic process, cytoplasm, hydrolase activity, mitochondrion - 1 M 4 YAR044W - - - - - - 1 M 5 YBL107C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBL107C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function - 1 M 6 YAR043C - - - - - - 1 M 7 YBL106C SRO77 SNI2|SOP2 Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p C, F, P molecular_function, plasma membrane, transport, vesicle-mediated transport - 1 M 8 YAR042W SWH1 OSH1|YAR044W Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction C, F, P Golgi apparatus, anatomical structure morphogenesis, cytoplasm, endomembrane system, endoplasmic reticulum, lipid binding, membrane organization and biogenesis, nucleus, transport, vesicle-mediated transport - 1 M 9 YBL104C - YBL103C-A Putative protein of unknown function, promoter contains multiple GCN4 binding sites C, F, P biological_process, cytoplasm, molecular_function - 1 M 10 YAR040C - - - - - - 1 M 11 YBL103C RTG3 - Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways C, F, P RNA metabolic process, cytoplasm, nucleus, signal transduction, transcription, transcription regulator activity - 1 M 12 YAR037W - - - - - - 1 M 13 YBL102W SFT2 - Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 C, F, P Golgi apparatus, cytoplasm, endomembrane system, membrane, molecular_function, transport, vesicle-mediated transport - 1 M 14 YAR035W YAT1 - Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated C, F, P amino acid and derivative metabolic process, mitochondrion, other, transferase activity, vitamin metabolic process - 1 M 15 YBL101C ECM21 - Non-essential protein of unknown function; promoter contains several Gcn4p binding elements C, F, P cell wall organization and biogenesis, cytoplasm, molecular_function - 1 M 16 YAR031W PRM9 - Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family C, F, P endoplasmic reticulum, membrane, molecular_function, organelle organization and biogenesis, plasma membrane, response to chemical stimulus - 1 M 17 YBL100C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1 C, F, P biological_process, cytoplasm, endomembrane system, endoplasmic reticulum, membrane, molecular_function - 1 M 18 YAR030C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 C, F, P biological_process, cellular_component, molecular_function - 1 M 19 YBL098W BNA4 - Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease C, F, P cofactor metabolic process, cytoplasm, membrane, mitochondrial envelope, mitochondrion, oxidoreductase activity, vitamin metabolic process - 1 M 20 YAR029W - - Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern C, F, P biological_process, cytoplasm, molecular_function - 1 M 21 YBL096C - - Non-essential protein of unknown function C, F, P biological_process, cellular_component, molecular_function - 1 M 22 YAR028W - - Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS C, F, P biological_process, cellular_component, molecular_function - 1 M 23 YBL095W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function - 1 M 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 N 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 N 2 YBR121C GRS1 - Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation C, F, P RNA metabolic process, amino acid and derivative metabolic process, cytoplasm, ligase activity, mitochondrion, transcription, translation - 1 N 3 YBR223C TDP1 - Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosyl bonds to generate 3'-phosphate DNA and tyrosine, involved in the repair of DNA lesions created by topoisomerase I C, F, P DNA metabolic process, hydrolase activity, nucleus, response to stress - 1 N 4 YBR119W MUD1 - U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing C, F, P RNA binding, RNA metabolic process, nucleus - 1 N 5 YBR222C PCS60 FAT2 Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase C, F, P biological_process, cytoplasm, membrane, other, peroxisome - 1 N 6 YBR116C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2 C, F, P biological_process, cellular_component, molecular_function - 1 N 7 YBR221C PDB1 - E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria C, F, P cytoplasm, mitochondrion, other, oxidoreductase activity - 1 N 8 YBR115C LYS2 - Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p C, F, P amino acid and derivative metabolic process, cytoplasm, oxidoreductase activity Lys biogenesis; Lys- 1 N 9 YBR220C - - Putative protein of unknown function; YBR220C is not an essential gene C, F, P biological_process, cellular_component, molecular_function - 1 N 10 YBR114W RAD16 PSO5 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex C, F, P DNA binding, DNA metabolic process, hydrolase activity, ligase activity, nucleus, organelle organization and biogenesis, other, protein catabolic process, protein modification process, response to stress - 1 N 11 YBR219C - - Putative protein of unknown function; YBR219C is not an essential gene C, F, P biological_process, cellular_component, molecular_function - 1 N 12 YBR113W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8 C, F, P biological_process, cellular_component, molecular_function - 1 N 13 YBR218C PYC2 - Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis C, F, P carbohydrate metabolic process, cofactor metabolic process, cytoplasm, ligase activity, vitamin metabolic process - 1 N 14 YBR111C YSA1 RMA2 Nudix hydrolase family member with ADP-ribose pyrophosphatase activity C, F, P biological_process, cytoplasm, hydrolase activity, mitochondrion, nucleus - 1 N 15 YBR217W ATG12 APG12 Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation C, F, P cytoplasm, ligase activity, membrane fraction, other, response to stress, transport - 1 N 16 YBR108W - - Protein interacting with Rsv167p; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media C, F, P biological_process, membrane, molecular_function - 1 N 17 YBR216C YBP1 - Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress C, F, P cytoplasm, molecular_function, response to chemical stimulus, response to stress - 1 N 18 YBR107C IML3 MCM19 Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p C, F, P cell cycle, chromosome, meiosis, molecular_function, nucleus, organelle organization and biogenesis, other, sporulation - 1 N 19 YBR215W HPC2 - Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes C, F, P DNA binding, RNA metabolic process, cell cycle, nucleus, organelle organization and biogenesis, other, transcription - 1 N 20 YBR106W PHO88 - Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations C, F, P membrane, mitochondrion, molecular_function, transport - 1 N 21 YBR214W SDS24 - One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis C, F, P cytoplasm, membrane organization and biogenesis, molecular_function, transport, vesicle-mediated transport - 1 N 22 YBR105C VID24 GID4 Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase C, F, P carbohydrate metabolic process, cytoplasmic membrane-bounded vesicle, membrane, membrane organization and biogenesis, molecular_function, organelle organization and biogenesis, protein catabolic process, transport, vesicle-mediated transport - 1 N 23 YBR213W MET8 - Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis C, F, P cellular_component, cofactor metabolic process, heterocycle metabolic process, lyase activity, other, oxidoreductase activity, response to chemical stimulus - 1 N 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 0 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 0 2 YBL015W ACH1 - Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth C, F, P cofactor metabolic process, cytoplasm, hydrolase activity, mitochondrion, other - 1 0 3 YBR016W - - Plasma membrane protein of unknown function; has similarity to hydrophilins, which are hydrophilic, glycine-rich proteins involved in the adaptive response to hyperosmotic conditions C, F, P molecular_function, plasma membrane, response to stress - 1 0 4 YBL013W FMT1 - Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate C, F, P RNA metabolic process, amino acid and derivative metabolic process, mitochondrion, transferase activity, translation - 1 0 5 YBR015C MNN2 LDB8|CRV4|TTP1 Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment C, F, P Golgi apparatus, protein modification process, transferase activity - 1 0 6 YBL011W SCT1 GAT2 Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed C, F, P endoplasmic reticulum, lipid metabolic process, transferase activity - 1 0 7 YBR014C GRX7 - Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; functional overlap with GRX6 C, F, P Golgi apparatus, cytoplasm, membrane fraction, oxidoreductase activity, protein binding, response to chemical stimulus, response to stress, vacuole - 1 0 8 YBL010C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles C, F, P biological_process, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function - 1 0 9 YBR013C - - Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein C, F, P biological_process, cellular_component, molecular_function - 1 0 10 YBL009W ALK2 - Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins C, F, P cell cycle, cellular_component, meiosis, protein kinase activity, protein modification process, transferase activity - 1 0 11 YBR012C - - Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p C, F, P biological_process, cellular_component, molecular_function - 1 0 12 YBL008W HIR1 - Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores C, F, P DNA binding, RNA metabolic process, chromosome, nucleus, organelle organization and biogenesis, other, protein binding, transcription, transcription regulator activity - 1 0 13 YBR010W HHT1 SIN2|BUR5 Core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see also HHT2); regulated by acetylation, methylation, and mitotic phosphorylation C, F, P DNA binding, DNA metabolic process, chromosome, nucleus, organelle organization and biogenesis, transposition - 1 0 14 YBL007C SLA1 - Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains C, F, P anatomical structure morphogenesis, cell budding, cell cortex, cell wall organization and biogenesis, cytokinesis, cytoskeleton organization and biogenesis, membrane organization and biogenesis, nucleus, organelle organization and biogenesis, protein binding, transport, vesicle-mediated transport - 1 0 15 YBR009C HHF1 - core histone H4 required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity C, F, P DNA binding, chromosome, nucleus, organelle organization and biogenesis - 1 0 16 YBL005W PDR3 TPE2|AMY2 Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements) C, F, P RNA metabolic process, cytoplasm, nucleus, response to chemical stimulus, transcription, transcription regulator activity - 1 0 17 YBR008C FLR1 - Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs C, F, P plasma membrane, response to chemical stimulus, transport, transporter activity - 1 0 18 YBL003C HTA2 H2A2 Core histone H2A required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p C, F, P DNA binding, DNA metabolic process, chromosome, nucleus, organelle organization and biogenesis, response to stress - 1 0 19 YBR007C DSF2 - Deletion suppressor of mpt5 mutation C, F, P biological_process, cellular_component, molecular_function - 1 0 20 YBL001C ECM15 - Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis C, F, P cell wall organization and biogenesis, cytoplasm, molecular_function, nucleus - 1 0 21 YBR006W UGA2 UGA5 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm C, F, P amino acid and derivative metabolic process, aromatic compound metabolic process, cytoplasm, lipid metabolic process, oxidoreductase activity, response to chemical stimulus, response to stress - 1 0 22 YAR050W FLO1 FLO4|FLO2 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p C, F, P cell wall, other - 1 0 23 YBR005W RCR1 SSH6 Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane C, F, P cell wall organization and biogenesis, cytoplasm, endomembrane system, endoplasmic reticulum, membrane, molecular_function, vesicle-mediated transport - 1 0 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 2 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 3 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 4 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 5 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 6 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 7 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 8 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 9 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 10 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 11 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 12 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 13 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 14 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 15 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 16 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 17 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 18 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 19 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 20 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 21 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 22 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 23 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 1 P 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 2 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 3 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 4 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 5 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 6 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 7 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 8 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 9 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 10 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 11 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 12 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 13 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 14 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 15 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 16 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 17 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 18 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 19 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 20 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 21 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 22 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 23 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 A 24 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 B 1 YOR202W HIS3 HIS10 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p C, F, P amino acid and derivative metabolic process, cellular_component, lyase activity - 2 B 2 YCR076C - - Putative protein of unknown function; YCR076C is not an essential gene C, F, P biological_process, cellular_component, molecular_function - 2 B 3 YDL090C RAM1 STE16|SGP2|SCG2|FUS8|DPR1 Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit C, F, P cytoplasm, protein modification process, transferase activity a-specific sterile 2 B 4 YCR075C ERS1 - Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains C, F, P cytoplasm, transport, transporter activity, vacuole - 2 B 5 YDL089W - - Protein of unknown function; interacts with meiotic division protein Csm1p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery, potential Cdc28p substrate C, F, P biological_process, cellular_component, molecular_function - 2 B 6 YCR073W-A SOL2 YCRX13W Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p C, F, P cytoplasm, molecular_function, transport - 2 B 7 YDL088C ASM4 NUP59 Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p C, F, P endomembrane system, membrane, nuclear organization and biogenesis, nucleus, organelle organization and biogenesis, structural molecule activity, transport - 2 B 8 YCR073C SSK22 - MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p C, F, P DNA metabolic process, cellular_component, protein kinase activity, protein modification process, response to stress, signal transducer activity, signal transduction, transferase activity, transposition - 2 B 9 YDL086W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene C, F, P biological_process, cytoplasm, hydrolase activity, mitochondrion - 2 B 10 YCR071C IMG2 - Mitochondrial ribosomal protein of the small subunit C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation petite 2 B 11 YDL085W NDE2 NDH2 Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain C, F, P cofactor metabolic process, generation of precursor metabolites and energy, mitochondrion, oxidoreductase activity, vitamin metabolic process - 2 B 12 YCR069W CPR4 SCC3|YCR070W|CYP4 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway C, F, P biological_process, isomerase activity, membrane - 2 B 13 YDL083C RPS16B - Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins C, F, P cytoplasm, ribosome, structural molecule activity, translation - 2 B 14 YCR068W ATG15 CVT17|AUT5 Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway C, F, P cytoplasm, hydrolase activity, membrane, membrane organization and biogenesis, other, protein modification process, vacuole - 2 B 15 YDL082W RPL13A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein C, F, P cytoplasm, ribosome, structural molecule activity, translation - 2 B 16 YCR067C SED4 - Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, molecular_function, transport, vesicle-mediated transport - 2 B 17 YDL081C RPP1A RPLA1 Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component C, F, P cytoplasm, ribosome, structural molecule activity, translation - 2 B 18 YCR065W HCM1 - Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role C, F, P DNA binding, RNA metabolic process, cell cycle, cytoskeleton organization and biogenesis, nucleus, organelle organization and biogenesis, transcription, transcription regulator activity - 2 B 19 YDL080C THI3 KID1 Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis C, F, P RNA metabolic process, amino acid and derivative metabolic process, cytoplasm, lyase activity, nucleus, transcription, vitamin metabolic process - 2 B 20 YCR063W BUD31 CWC14 Protein involved in bud-site selection; analysis of integrated high-throughput datasets predicts an involvement in RNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern C, F, P RNA metabolic process, anatomical structure morphogenesis, cytokinesis, molecular_function, nucleus - 2 B 21 YDL079C MRK1 - Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3