mat alpha Synced to SGD on Fri Aug 1 09:00:50 2008 plate row column ORF Gene Alias Description GO Aspect GO Term record no. strain batch RG notes Consortium Notes Bob's notes from 9/2004 1 A 2 YAL068C - - Hypothetical protein C, F, P RNA metabolic process, cellular_component, molecular_function, sporulation, transcription 10338 BY4739 01_1 1 A 3 YAL067C SEO1 - Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide C, F, P membrane, transport, transporter activity 10339 BY4739 01_1 1 A 4 YAL066W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 10340 BY4739 01_1 1 A 5 YAL065C - - Putative protein of unknown function; has homology to FLO1; possible pseudogene C, F, P biological_process, cellular_component, molecular_function 10341 BY4739 01_1 1 A 6 YAL062W GDH3 FUN51 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources C, F, P amino acid and derivative metabolic process, mitochondrion, nucleus, other, oxidoreductase activity 10345 BY4739 01_1 1 A 7 YAL061W BDH2 - Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene C, F, P biological_process, cytoplasm, nucleus, oxidoreductase activity 10346 BY4739 01_1 1 A 8 YAL060W BDH1 - NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source C, F, P cytoplasm, other, oxidoreductase activity 10347 BY4739 01_1 1 A 9 YAL059W ECM1 - Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export C, F, P cell wall organization and biogenesis, molecular_function, nucleolus, nucleus, organelle organization and biogenesis, ribosome biogenesis, transport 10348 BY4739 01_1 1 A 10 YAL058W CNE1 FUN48 Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, protein binding, protein catabolic process, protein folding 10349 BY4739 01_1 1 A 11 YAL056W GPB2 KRH1 Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p C, F, P RNA metabolic process, cytoplasm, enzyme regulator activity, mitochondrion, other, plasma membrane, protein binding, pseudohyphal growth, response to chemical stimulus, signal transducer activity, signal transduction, sporulation, transcription 10351 BY4739 01_1 1 A 12 YAL055W PEX22 YAF5 Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation C, F, P cytoplasm, membrane, organelle organization and biogenesis, peroxisome, protein binding, signal transduction, transport 10352 BY4739 01_1 1 B 1 YAL053W FLC2 HUF2 Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance C, F, P cell wall organization and biogenesis, cytoplasm, endoplasmic reticulum, protein folding, transport, transporter activity 10354 BY4739 01_1 1 B 2 YAL051W OAF1 YAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis C, F, P DNA binding, lipid metabolic process, nucleus, organelle organization and biogenesis, response to chemical stimulus, transcription, transcription regulator activity 10355 BY4739 01_1 1 B 3 YAL049C - - Cytoplasmic protein of unknown function, potential Hsp82p interactor; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) C, F, P biological_process, cytoplasm, molecular_function 10356 BY4739 01_1 1 B 4 YAL048C GEM1 GON1 Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death C, F, P cytoplasm, hydrolase activity, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, vesicle-mediated transport 10357 BY4739 01_1 1 B 5 YAL046C - - Putative protein of unknown function; null mutant displays increased frequency of mitochondrial genome loss (petite formation) C, F, P biological_process, cellular_component, molecular_function 10359 BY4739 01_1 1 B 6 YAL045C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A C, F, P biological_process, cellular_component, molecular_function 10360 BY4739 01_1 1 B 7 YAL044C GCV3 - H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm C, F, P amino acid and derivative metabolic process, cytoplasm, mitochondrion, other, oxidoreductase activity 10361 BY4739 01_1 1 B 8 YAL042W ERV46 FUN9 Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, endomembrane system, endoplasmic reticulum, membrane, molecular_function, transport, vesicle-mediated transport 10363 BY4739 01_1 1 B 9 YAL042C-A - YAL043C-A Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene C, F, P biological_process, cellular_component, molecular_function 10364 BY4739 01_1 1 B 10 YAL040C CLN3 WHI1|FUN10|DAF1 G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis C, F, P cell cycle, enzyme regulator activity, membrane organization and biogenesis, nucleus, organelle organization and biogenesis, other 10366 BY4739 01_1 1 B 11 YAL037W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 10369 BY4739 01_1 1 B 12 YAL036C RBG1 FUN11 Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46p C, F, P cytoplasm, other, ribosome biogenesis 10370 BY4739 01_1 1 C 1 YAL035W FUN12 yIF2 GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2 C, F, P cytoplasm, hydrolase activity, mitochondrion, ribosome, translation, translation regulator activity 10371 BY4739 01_1 1 C 2 YAL034C FUN19 - Non-essential protein of unknown function C, F, P biological_process, cellular_component, molecular_function 10374 BY4739 01_1 1 C 3 YAL031C GIP4 FUN21 Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate C, F, P cytoplasm, enzyme regulator activity, other, protein binding 10377 BY4739 01_1 1 C 4 YAL030W SNC1 - Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, membrane, membrane organization and biogenesis, organelle organization and biogenesis, protein binding, transport, vesicle-mediated transport 10378 BY4739 01_1 1 C 5 YAL029C MYO4 SHE1|FUN22 One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p C, F, P DNA metabolic process, cellular bud, cytoskeleton, mitochondrion, motor activity, organelle organization and biogenesis, other, protein binding 10379 BY4739 01_1 1 C 6 YAL028W FRT2 HPH2 Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate C, F, P endoplasmic reticulum, molecular_function, response to stress 10380 BY4739 01_1 1 C 7 YAL026C DRS2 SWA3|FUN38 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease C, F, P Golgi apparatus, cytoplasm, hydrolase activity, membrane organization and biogenesis, organelle organization and biogenesis, ribosome biogenesis, transport, transporter activity, vesicle-mediated transport 10382 BY4739 01_1 1 C 8 YAL023C PMT2 FUN25 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals C, F, P endoplasmic reticulum, protein modification process, transferase activity 10385 BY4739 01_1 1 C 9 YAL022C FUN26 - Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes C, F, P membrane, other, transport, transporter activity 10386 BY4739 01_1 1 C 10 YAL021C CCR4 NUT21|FUN27 Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening C, F, P DNA metabolic process, RNA metabolic process, cell cycle, cytoplasm, hydrolase activity, nucleus, response to chemical stimulus, transcription 10387 BY4739 01_1 1 C 11 YAL020C ATS1 KTI13|FUN28 Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle C, F, P RNA metabolic process, cell budding, cytoplasm, cytoskeleton organization and biogenesis, molecular_function, organelle organization and biogenesis 10388 BY4739 01_1 1 C 12 YAL019W FUN30 - Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P mitochondrion, molecular_function, nucleus, organelle organization and biogenesis 10389 BY4739 01_1 1 D 1 YAL018C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 10390 BY4739 01_1 1 D 2 YAL017W PSK1 FUN31 One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status C, F, P carbohydrate metabolic process, cell wall organization and biogenesis, cytoplasm, protein kinase activity, protein modification process, transferase activity 10391 BY4739 01_1 1 D 3 YAL015C NTG1 SCR1|FUN33 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion C, F, P DNA metabolic process, hydrolase activity, lyase activity, mitochondrion, nucleus, response to stress 10393 BY4739 01_1 1 D 4 YAL014C SYN8 SLT2|UIP2 Endosomal SNARE related to mammalian syntaxin 8 C, F, P cytoplasm, protein binding, transport 10394 BY4739 01_1 1 D 5 YAL013W DEP1 FUN54 Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation C, F, P RNA metabolic process, hydrolase activity, lipid metabolic process, nucleus, organelle organization and biogenesis, protein modification process, transcription, transcription regulator activity 10395 BY4739 01_1 1 D 6 YAL011W SWC3 SWC1 Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae C, F, P mitochondrion, molecular_function, nucleus, organelle organization and biogenesis, response to chemical stimulus 10397 BY4739 01_1 1 D 7 YAL010C MDM10 FUN37 Subunit of both the Mdm10-Mdm12-Mmm1 complex and the mitochondrial sorting and assembly machinery (SAM complex); functions in both the general and Tom40p-specific pathways for import and assembly of outer membrane beta-barrel proteins C, F, P cytoplasm, membrane, membrane organization and biogenesis, mitochondrial envelope, mitochondrion, molecular_function, organelle organization and biogenesis, other, transport 10398 BY4739 01_1 1 D 8 YAL009W SPO7 - Regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation C, F, P endomembrane system, meiosis, membrane, nuclear organization and biogenesis, phosphoprotein phosphatase activity, sporulation 10399 BY4739 01_1 1 D 9 YAL008W FUN14 - Mitochondrial protein of unknown function C, F, P biological_process, cytoplasm, membrane, mitochondrial envelope, mitochondrion, molecular_function 10400 BY4739 01_1 1 D 10 YAL007C ERP2 - Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function, transport, vesicle-mediated transport 10401 BY4739 01_1 1 D 11 YAL004W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C C, F, P biological_process, cellular_component, molecular_function 10402 BY4739 01_1 1 D 12 YAL005C SSA1 YG100 ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall C, F, P cell wall, cytoplasm, hydrolase activity, membrane, nucleus, organelle organization and biogenesis, protein binding, protein folding, response to stress, translation, transport, vacuole 10403 BY4739 01_1 1 E 1 YAL002W VPS8 VPT8|FUN15 Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif C, F, P cytoplasm, membrane fraction, molecular_function, transport, vesicle-mediated transport 10405 BY4739 01_1 1 E 2 YAR002W NUP60 - Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance C, F, P endomembrane system, membrane, nucleus, structural molecule activity, transport 10407 BY4739 01_1 1 E 3 YAR003W SWD1 SAF49|CPS50|FUN16 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 C, F, P RNA metabolic process, nucleus, organelle organization and biogenesis, protein modification process, transcription, transferase activity 10408 BY4739 01_1 1 E 4 YAR014C BUD14 - Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern C, F, P RNA metabolic process, anatomical structure morphogenesis, cellular bud, cytoskeleton organization and biogenesis, enzyme regulator activity, other, site of polarized growth, transcription 10413 BY4739 01_1 1 E 5 YAR015W ADE1 - N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine C, F, P cytoplasm, ligase activity, nucleus, other, response to chemical stimulus 10414 BY4739 01_1 1 E 6 YAR018C KIN3 NPK1|FUN52 Nonessential protein kinase with unknown cellular role C, F, P cellular_component, other, protein kinase activity 10415 BY4739 01_1 1 E 7 YAR020C PAU7 - Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme C, F, P biological_process, cellular_component, molecular_function 10417 BY4739 01_1 1 E 8 YAR023C - - Putative integral membrane protein, member of DUP240 gene family C, F, P biological_process, cellular_component, molecular_function 10418 BY4739 01_1 1 E 9 YAR027W UIP3 - Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family C, F, P biological_process, endomembrane system, molecular_function, nucleus 10419 BY4739 01_1 1 E 10 YAR028W - - Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS C, F, P biological_process, cellular_component, molecular_function 10420 BY4739 01_1 1 E 11 YAR029W - - Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern C, F, P biological_process, cytoplasm, molecular_function 10421 BY4739 01_1 1 E 12 YAR031W PRM9 - Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family C, F, P endoplasmic reticulum, membrane, molecular_function, organelle organization and biogenesis, plasma membrane, response to chemical stimulus 10422 BY4739 01_1 1 F 1 YAR030C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 C, F, P biological_process, cellular_component, molecular_function 10423 BY4739 01_1 1 F 2 YAR035W YAT1 - Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated C, F, P amino acid and derivative metabolic process, mitochondrion, other, transferase activity, vitamin metabolic process 10425 BY4739 01_1 1 F 3 YAR037W - - - - - 10426 BY4739 01_1 deleted from SGD as ORF - partial del of YAT1 1 F 4 YAR040C - - - - - 10427 BY4739 01_1 deleted from SGD as ORF - partial del of YAT1 1 F 5 YAR042W SWH1 OSH1|YAR044W Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction C, F, P Golgi apparatus, anatomical structure morphogenesis, cytoplasm, endomembrane system, endoplasmic reticulum, lipid binding, membrane organization and biogenesis, nucleus, transport, vesicle-mediated transport 10428 BY4739 01_1 YAR042W and YAR044W were merged to create one orf. This listing is a partial delete 1 F 6 YAR043C-a - - - - - 10429 BY4739 01_1 deleted from SGD - partial del of SWH1 1 F 7 YAR044W - - - - - 10430 BY4739 01_1 YAR042W and YAR044W were merged to create one orf. This listing is a partial delete 1 F 8 YAR047C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 10431 BY4739 01_1 1 F 9 YLL001W DNM1 - Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology, assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis C, F, P cytoplasm, hydrolase activity, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, other, protein binding 11489 BY4742 12_1 1 F 10 YLL002W RTT109 REM50|KIM2 Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in non-homologous end-joining and in regulation of Ty1 transposition; interacts physically with Vps75p C, F, P DNA metabolic process, nucleus, organelle organization and biogenesis, protein modification process, response to stress, transferase activity, transposition 11490 BY4742 12_1 1 F 11 YLL005C SPO75 - Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis C, F, P cell wall organization and biogenesis, cellular_component, molecular_function, sporulation 11493 BY4742 12_1 1 F 12 YLL010C PSR1 - Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p C, F, P phosphoprotein phosphatase activity, plasma membrane, response to stress 11498 BY4742 12_1 1 G 1 YLL012W YEH1 - Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes C, F, P cytoplasm, hydrolase activity, lipid metabolic process, membrane 11500 BY4742 12_1 1 G 2 YLL013C PUF3 - Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins C, F, P RNA binding, RNA metabolic process, cellular respiration, cytoplasm, generation of precursor metabolites and energy, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, other 11501 BY4742 12_1 1 G 3 YLL014W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLL014W is not an essential gene C, F, P biological_process, endoplasmic reticulum, molecular_function 11502 BY4742 12_1 1 G 4 YLL015W BPT1 - ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p C, F, P cytoplasm, membrane, transport, transporter activity, vacuole 11503 BY4742 12_1 1 G 5 YLL016W - - - - - 11504 BY4742 12_1 1 G 6 YLL017W - - - - - 11505 BY4742 12_1 1 G 7 YLL019C KNS1 L124 Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues C, F, P cellular_component, protein kinase activity, protein modification process, transferase activity 11507 BY4742 12_1 1 G 8 YLL020C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1 C, F, P biological_process, cellular_component, molecular_function 11508 BY4742 12_1 1 G 9 YLL021W SPA2 PEA1|FUS6 Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate C, F, P anatomical structure morphogenesis, cell budding, cell cortex, cellular bud, conjugation, cytokinesis, cytoplasm, cytoskeleton organization and biogenesis, organelle organization and biogenesis, other, protein binding, pseudohyphal growth, response to chemical stimulus, signal transduction, site of polarized growth 11509 BY4742 12_1 1 G 10 YLL023C - - Protein of unknown function; highly conserved across species and orthologous to human TMEM33; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the endoplasmic reticulum C, F, P biological_process, endoplasmic reticulum, molecular_function, ribosome 11511 BY4742 12_1 1 G 11 YLL024C SSA2 YG102 ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall C, F, P cell wall, cytoplasm, hydrolase activity, membrane, mitochondrion, other, protein binding, protein folding, response to stress, transport, vacuole 11512 BY4742 12_1 1 G 12 YLL025W - - Putative protein of unknown function; YLL025W is not an essential gene C, F, P biological_process, cellular_component, molecular_function 11513 BY4742 12_1 1 H 1 YLL026W HSP104 - Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation C, F, P cytoplasm, hydrolase activity, nucleus, protein binding, protein folding, response to stress 11514 BY4742 12_1 1 H 2 YLL028W TPO1 - Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane C, F, P cellular bud, cytoplasm, membrane, plasma membrane, transport, transporter activity, vacuole 11516 BY4742 12_1 1 H 4 YLL029W FRA1 RUP2 Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation C, F, P RNA metabolic process, cytoplasm, molecular_function, response to chemical stimulus, transcription 11517 BY4742 12_1 1 H 5 YLL032C - - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, ribosome 11520 BY4742 12_1 1 H 6 YLL038C ENT4 - Protein of unknown function, contains an N-terminal epsin-like domain C, F, P cell cortex, cytoplasm, cytoskeleton, cytoskeleton organization and biogenesis, membrane organization and biogenesis, organelle organization and biogenesis, protein binding, transport, vesicle-mediated transport 11526 BY4742 12_1 1 H 7 YLL039C UBI4 UB14|SCD2 Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats C, F, P cytoplasm, other, protein binding, protein modification process, response to stress, sporulation 11527 BY4742 12_1 1 H 8 YLL040C VPS13 VPT2|SOI1 Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention C, F, P cytoplasm, membrane, mitochondrion, molecular_function, other, protein catabolic process, sporulation, transport, vesicle-mediated transport 11528 BY4742 12_1 1 H 9 YLL041C SDH2 ACN17 Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone C, F, P cellular respiration, cofactor metabolic process, cytoplasm, generation of precursor metabolites and energy, membrane, mitochondrial envelope, mitochondrion, oxidoreductase activity 11529 BY4742 12_1 1 H 10 YLL043W FPS1 - Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress C, F, P conjugation, cytoplasm, plasma membrane, response to chemical stimulus, transport, transporter activity, vacuole 11531 BY4742 12_1 1 H 11 YLL045C RPL8B SCL41|KRB1 Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits C, F, P cytoplasm, ribosome, structural molecule activity, translation 11533 BY4742 12_1 1 H 12 YLL046C RNP1 - Ribonucleoprotein that contains two RNA recognition motifs (RRM) C, F, P RNA binding, cytoplasm, ribosome biogenesis 11534 BY4742 12_1 2 A 1 YLL047W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1 C, F, P biological_process, cellular_component, molecular_function 11535 BY4742 12_1 2 A 3 YLL051C FRE6 - Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels C, F, P cellular homeostasis, cytoplasm, membrane, oxidoreductase activity, transport, vacuole 11539 BY4742 12_1 2 A 4 YLL052C AQY2 - Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, plasma membrane, transport, transporter activity 11540 BY4742 12_1 2 A 5 YLL053C - - Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin C, F, P biological_process, cellular_component, molecular_function 11541 BY4742 12_1 2 A 6 YLL054C - - Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene C, F, P biological_process, plasma membrane, transcription regulator activity 11542 BY4742 12_1 2 A 7 YLL055W YCT1 - High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene C, F, P endoplasmic reticulum, transport, transporter activity 11543 BY4742 12_1 2 A 8 YLL056C - - Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene C, F, P cellular_component, molecular_function, response to chemical stimulus 11544 BY4742 12_1 2 A 9 YLL057C JLP1 - Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) C, F, P cellular_component, other, oxidoreductase activity 11545 BY4742 12_1 2 A 10 YLL058W - - Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene C, F, P cellular_component, other, transferase activity 11546 BY4742 12_1 2 A 11 YLL060C GTT2 - Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p C, F, P cofactor metabolic process, mitochondrion, response to chemical stimulus, transferase activity 11548 BY4742 12_1 2 A 12 YLL061W MMP1 - High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p C, F, P plasma membrane, transport, transporter activity 11549 BY4742 12_1 2 B 1 YLL062C MHT1 - S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio C, F, P amino acid and derivative metabolic process, cytoplasm, transferase activity 11550 BY4742 12_1 2 B 2 YLL063C AYT1 - Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis C, F, P cellular_component, other, transferase activity 11551 BY4742 12_1 2 B 3 YLR001C - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR001C is not an essential gene C, F, P biological_process, cytoplasm, membrane, mitochondrion, molecular_function, vacuole 11556 BY4742 12_1 2 B 4 YLR003C - CMS1 Putative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene C, F, P DNA metabolic process, cytoplasm, molecular_function, nucleolus, nucleus, ribosome biogenesis 11558 BY4742 12_1 2 B 5 YLR004C THI73 - Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs C, F, P endoplasmic reticulum, membrane, transport, transporter activity 11559 BY4742 12_1 2 B 6 YLR011W LOT6 - FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature C, F, P cytoplasm, nucleus, oxidoreductase activity, response to chemical stimulus, response to stress 11566 BY4742 12_1 2 B 7 YLR012C - - Putative protein of unknown function; YLR012C is not an essential gene C, F, P biological_process, cellular_component, molecular_function 11567 BY4742 12_1 2 B 8 YLR013W GAT3 - Protein containing GATA family zinc finger motifs C, F, P DNA binding, nucleus, transcription, transcription regulator activity 11568 BY4742 12_1 2 B 9 YLR014C PPR1 - Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p C, F, P DNA binding, RNA metabolic process, aromatic compound metabolic process, heterocycle metabolic process, nucleus, transcription, transcription regulator activity 11569 BY4742 12_1 2 B 10 YLR015W BRE2 CPS60 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L C, F, P RNA metabolic process, nucleus, organelle organization and biogenesis, protein modification process, transcription, transcription regulator activity, transferase activity 11570 BY4742 12_1 2 B 11 YLR016C PML1 - Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p C, F, P RNA metabolic process, cytoplasm, molecular_function, nucleus, transport 11571 BY4742 12_1 2 B 12 YLR017W MEU1 - Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression C, F, P amino acid and derivative metabolic process, cytoplasm, transferase activity 11572 BY4742 12_1 2 C 1 YLR018C POM34 - Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex C, F, P endomembrane system, membrane, molecular_function, nucleus, transport 11573 BY4742 12_1 2 C 2 YLR019W PSR2 - Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p C, F, P phosphoprotein phosphatase activity, plasma membrane, response to stress 11574 BY4742 12_1 2 C 3 YLR020C YEH2 - Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism C, F, P cell wall organization and biogenesis, hydrolase activity, lipid metabolic process, membrane, plasma membrane 11575 BY4742 12_1 2 C 4 YLR021W IRC25 DMP2|PBA3|POC3 Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions C, F, P molecular_function, other 11576 BY4742 12_1 2 C 5 YLR023C IZH3 - Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity C, F, P cellular homeostasis, endoplasmic reticulum, lipid metabolic process, membrane, other 11578 BY4742 12_1 2 C 6 YLR024C UBR2 - Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex C, F, P cytoplasm, ligase activity, protein modification process 11579 BY4742 12_1 2 C 7 YLR025W SNF7 RNS4|VPS32|DID1 One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes C, F, P cytoplasm, membrane, protein binding, protein catabolic process, transport, vesicle-mediated transport 11580 BY4742 12_1 2 C 8 YLR028C ADE16 - Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine C, F, P cellular respiration, cytoplasm, generation of precursor metabolites and energy, hydrolase activity, other, sporulation, transferase activity 11583 BY4742 12_1 2 C 9 YLR042C - - Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene C, F, P biological_process, cell wall, molecular_function 12653 BY4742 12_2 2 C 10 YLR043C TRX1 LMA1 Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance C, F, P DNA metabolic process, cellular homeostasis, cytoplasm, membrane organization and biogenesis, organelle organization and biogenesis, other, oxidoreductase activity, response to chemical stimulus, response to stress, transport, vacuole, vesicle-mediated transport 12654 BY4742 12_2 2 C 11 YLR044C PDC1 - Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism C, F, P amino acid and derivative metabolic process, aromatic compound metabolic process, cytoplasm, generation of precursor metabolites and energy, heterocycle metabolic process, lyase activity, nucleus, other 12655 BY4742 12_2 2 C 12 YLR046C - RLA1 Putative membrane protein, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance C, F, P biological_process, membrane, molecular_function 12657 BY4742 12_2 2 D 1 YLR047C FRE8 - Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p C, F, P cellular homeostasis, membrane, oxidoreductase activity 12658 BY4742 12_2 2 D 2 YLR048W RPS0B YST2|NAB1B Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal C, F, P cytoplasm, organelle organization and biogenesis, ribosome, ribosome biogenesis, structural molecule activity, translation 12659 BY4742 12_2 2 D 3 YLR049C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 12660 BY4742 12_2 2 D 4 YLR053C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 12664 BY4742 12_2 2 D 5 YLR054C OSW2 - Protein of unknown function proposed to be involved in the assembly of the spore wall C, F, P cell wall organization and biogenesis, cytoplasm, membrane, molecular_function, sporulation 12665 BY4742 12_2 2 D 6 YLR055C SPT8 - Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters C, F, P RNA metabolic process, nucleus, protein binding, transcription, transcription regulator activity 12666 BY4742 12_2 2 D 7 YLR056W ERG3 PSO6|SYR1 C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources C, F, P endoplasmic reticulum, lipid metabolic process, membrane organization and biogenesis, oxidoreductase activity, transport, vesicle-mediated transport 12667 BY4742 12_2 2 D 8 YLR057W - - Putative protein of unknown function; YLR050C is not an essential gene C, F, P biological_process, cellular_component, molecular_function 12668 BY4742 12_2 2 D 9 YLR058C SHM2 SHMT2 Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis C, F, P cytoplasm, other, transferase activity 12669 BY4742 12_2 2 D 10 YLR059C REX2 YNT20 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease C, F, P RNA metabolic process, hydrolase activity, mitochondrion, organelle organization and biogenesis, ribosome biogenesis 12670 BY4742 12_2 2 D 11 YLR061W RPL22A - Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein C, F, P cytoplasm, ribosome, structural molecule activity, translation 12672 BY4742 12_2 2 D 12 YLR062C BUD28 - Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay C, F, P anatomical structure morphogenesis, cellular_component, cytokinesis, molecular_function 12673 BY4742 12_2 2 E 1 YLR063W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene C, F, P biological_process, cytoplasm, molecular_function 12674 BY4742 12_2 2 E 2 YLR064W - - Putative protein of unknown function; highly conserved across species and orthologous to human TMEM33; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR064W is not an essential gene C, F, P biological_process, endoplasmic reticulum, molecular_function 12675 BY4742 12_2 2 E 3 YLR065C - - Putative protein of unknown function; YLR065C is not an essential gene C, F, P biological_process, cellular_component, molecular_function 12676 BY4742 12_2 2 E 4 YLR068W FYV7 - Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin C, F, P RNA metabolic process, molecular_function, nucleolus, nucleus, organelle organization and biogenesis, ribosome biogenesis 12679 BY4742 12_2 2 E 5 YLR072W - - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene C, F, P biological_process, cytoplasm, molecular_function 12683 BY4742 12_2 2 E 6 YLR073C - - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes; YLR073C is not an esssential gene C, F, P biological_process, cytoplasm, molecular_function 12684 BY4742 12_2 2 E 7 YLR074C BUD20 - Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern C, F, P anatomical structure morphogenesis, cytokinesis, molecular_function, nucleus, ribosome biogenesis 12685 BY4742 12_2 2 E 8 YLR077W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function 12688 BY4742 12_2 2 E 9 YLR079W SIC1 SDB25 Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 C, F, P DNA metabolic process, cell cycle, cytoplasm, enzyme regulator activity, nucleus, transposition 12690 BY4742 12_2 2 E 10 YLR080W EMP46 - Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, endomembrane system, membrane, protein binding, transport, vesicle-mediated transport 12691 BY4742 12_2 2 E 11 YLR081W GAL2 - Galactose permease, required for utilization of galactose; also able to transport glucose C, F, P carbohydrate metabolic process, plasma membrane, transport, transporter activity 12692 BY4742 12_2 2 E 12 YLR082C SRL2 - Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation C, F, P cytoplasm, molecular_function, nucleus, other 12693 BY4742 12_2 2 F 1 YLR083C EMP70 TMN1|p24a Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions C, F, P cytoplasm, molecular_function, other, pseudohyphal growth 12694 BY4742 12_2 2 F 2 YLR084C RAX2 - N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p C, F, P anatomical structure morphogenesis, cell wall, cellular bud, cytokinesis, membrane, mitochondrion, molecular_function, site of polarized growth 12695 BY4742 12_2 2 F 3 YLR085C ARP6 - Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A C, F, P cytoplasm, nucleus, organelle organization and biogenesis, other 12696 BY4742 12_2 2 F 4 YLR087C CSF1 - Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P generation of precursor metabolites and energy, mitochondrion, molecular_function 12698 BY4742 12_2 2 F 5 YLR089C ALT1 - Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, transferase activity 12700 BY4742 12_2 2 F 6 YLR090W XDJ1 - Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P Golgi apparatus, cytoplasm, endomembrane system, membrane, mitochondrial envelope, mitochondrion, nucleus, other, protein folding 12701 BY4742 12_2 2 F 7 YLR092W SUL2 - High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates C, F, P plasma membrane, transport, transporter activity 12703 BY4742 12_2 2 F 8 YLR093C NYV1 MAM2 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane C, F, P cytoplasm, membrane, membrane organization and biogenesis, organelle organization and biogenesis, protein binding, transport, vacuole, vesicle-mediated transport 12704 BY4742 12_2 2 F 9 YLR094C GIS3 - Protein of unknown function C, F, P cytoplasm, molecular_function, nucleus, signal transduction 12705 BY4742 12_2 2 F 10 YLR095C IOC2 - Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif C, F, P nucleus, organelle organization and biogenesis, protein binding 12706 BY4742 12_2 2 F 11 YLR096W KIN2 - Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p C, F, P plasma membrane, protein kinase activity, protein modification process, transferase activity, transport, vesicle-mediated transport 12707 BY4742 12_2 2 F 12 YLR097C HRT3 - Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies C, F, P ligase activity, other, protein catabolic process, protein modification process 12708 BY4742 12_2 2 G 1 YLR098C CHA4 SIL3|SIL2 DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain C, F, P DNA binding, RNA metabolic process, amino acid and derivative metabolic process, nucleus, transcription, transcription regulator activity 12709 BY4742 12_2 2 G 2 YLR099C ICT1 - Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress C, F, P cellular_component, lipid metabolic process, transferase activity 12710 BY4742 12_2 2 G 3 YLR102C APC9 - Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition C, F, P cell cycle, cytoskeleton organization and biogenesis, ligase activity, nucleus, organelle organization and biogenesis, protein binding, protein catabolic process, protein modification process 12713 BY4742 12_2 2 G 4 YLR104W - - Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate C, F, P biological_process, cellular_component, molecular_function 12715 BY4742 12_2 2 G 5 YLR107W REX3 - RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases C, F, P RNA metabolic process, cytoplasm, hydrolase activity, nucleus, organelle organization and biogenesis, ribosome biogenesis 12718 BY4742 12_2 2 G 6 YLR108C - - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene C, F, P biological_process, molecular_function, nucleus 12719 BY4742 12_2 2 G 7 YLR109W AHP1 - Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p C, F, P cellular homeostasis, cytoplasm, oxidoreductase activity, response to chemical stimulus, response to stress 12720 BY4742 12_2 2 G 8 YLR111W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 12722 BY4742 12_2 2 G 9 YLR112W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 12723 BY4742 12_2 2 G 10 YLR113W HOG1 SSK3 Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p C, F, P RNA metabolic process, cytoplasm, nucleus, protein kinase activity, protein modification process, response to chemical stimulus, response to stress, signal transducer activity, signal transduction, transcription, transferase activity 12724 BY4742 12_2 2 G 11 YLR114C AVL9 - Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms C, F, P cytoplasm, molecular_function, transport, vesicle-mediated transport 12725 BY4742 12_2 2 G 12 YLR118C - APT1 Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS C, F, P biological_process, cytoplasm, hydrolase activity, nucleus 12729 BY4742 12_2 2 H 1 YLR119W SRN2 VPS37|SRN10 Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus C, F, P cytoplasm, membrane, protein binding, protein catabolic process, transport 12730 BY4742 12_2 2 H 2 YLR120C YPS1 YAP3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor C, F, P cell wall, hydrolase activity, peptidase activity, protein modification process 12731 BY4742 12_2 2 H 4 YLR121C YPS3 YPS4 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor C, F, P cell wall organization and biogenesis, hydrolase activity, membrane, other, peptidase activity, plasma membrane, structural molecule activity 12732 BY4742 12_2 2 H 5 YLR122C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C C, F, P biological_process, cellular_component, molecular_function 12733 BY4742 12_2 2 H 6 YLR123C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif C, F, P biological_process, cellular_component, molecular_function 12734 BY4742 12_2 2 H 7 YLR124W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 12735 BY4742 12_2 2 H 8 YLR125W - - Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene C, F, P biological_process, cellular_component, molecular_function 12736 BY4742 12_2 2 H 9 YML089C - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage C, F, P biological_process, cellular_component, molecular_function 10481 BY4739 13_1 2 H 10 YML088W UFO1 - F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation C, F, P cytoplasm, ligase activity, nucleus, other, protein binding, protein catabolic process, response to stress 10482 BY4739 13_1 2 H 11 YML087C - - Putative protein of unknown function; highly conserved across species and orthologous to human CYB5R4; null mutant shows increased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media C, F, P biological_process, cellular_component, molecular_function 10483 BY4739 13_1 2 H 12 YML084W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 10486 BY4739 13_1 3 A 1 YML083C - - Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions C, F, P biological_process, cellular_component, molecular_function 10487 BY4739 13_1 3 A 2 YML082W - - Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene C, F, P cytoplasm, lyase activity, nucleus, other 10488 BY4739 13_1 3 A 4 YML081W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene C, F, P biological_process, molecular_function, nucleus 10489 BY4739 13_1 3 A 5 YML080W DUS1 - Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 C, F, P RNA metabolic process, nucleus, oxidoreductase activity 10490 BY4739 13_1 3 A 6 YML079W - - Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm C, F, P biological_process, cytoplasm, molecular_function, nucleus 10491 BY4739 13_1 3 A 7 YML078W CPR3 CYP3 Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria C, F, P isomerase activity, mitochondrion, other, protein folding 10492 BY4739 13_1 3 A 8 YML063W RPS1B RP10B|PLC2 Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein C, F, P cytoplasm, nucleolus, nucleus, ribosome, structural molecule activity, translation 10507 BY4742 13_1 3 A 9 YML062C MFT1 MFT52 Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance C, F, P DNA metabolic process, RNA metabolic process, nucleus, other, transcription, transport 10508 BY4742 13_1 3 A 10 YML060W OGG1 - Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA C, F, P DNA metabolic process, hydrolase activity, lyase activity, mitochondrion, response to stress 10510 BY4742 13_1 3 A 11 YML059C NTE1 - Serine esterase that deacylates exogenous lysophospholipids, homolog of human neuropathy target esterase (NTE); mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine C, F, P endoplasmic reticulum, hydrolase activity, lipid metabolic process 10511 BY4742 13_1 3 A 12 YML058W SML1 - Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase C, F, P cytoplasm, enzyme regulator activity, nucleus, organelle organization and biogenesis, response to stress 10512 BY4742 13_1 3 B 1 YML057W CMP2 CNA2 Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 C, F, P cellular homeostasis, conjugation, cytoplasm, hydrolase activity, other, phosphoprotein phosphatase activity, response to chemical stimulus, signal transduction 10513 BY4742 13_1 3 B 2 YML057C-A - YML058C-A Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W C, F, P biological_process, cellular_component, molecular_function 10514 BY4742 13_1 3 B 3 YML056C IMD4 - Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed C, F, P biological_process, cytoplasm, oxidoreductase activity 10515 BY4742 13_1 3 B 4 YML055W SPC2 SPY1 Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, protein binding, protein modification process, transport 10516 BY4742 13_1 3 B 5 YML054C CYB2 - Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions C, F, P cytoplasm, mitochondrial envelope, mitochondrion, other, oxidoreductase activity 10517 BY4742 13_1 3 B 6 YML053C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YML053C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus 10518 BY4742 13_1 3 B 7 YML052W SUR7 - Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants C, F, P cell cortex, cell wall, membrane, membrane fraction, membrane organization and biogenesis, mitochondrion, molecular_function, plasma membrane, sporulation, transport, vesicle-mediated transport 10519 BY4742 13_1 3 B 8 YML051W GAL80 - Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding C, F, P RNA metabolic process, carbohydrate metabolic process, cytoplasm, nucleus, response to chemical stimulus, transcription, transcription regulator activity 10520 BY4742 13_1 3 B 9 YML050W - - Putative protein of unknown function; non-essential gene; null mutant displays increased frequency of mitochondrial genome loss (petite formation) C, F, P biological_process, cellular_component, molecular_function 10521 BY4742 13_1 3 B 10 YML048W GSF2 ECM6 ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, mitochondrial envelope, mitochondrion, molecular_function, protein folding, transport 10523 BY4742 13_1 3 B 11 YML047W-A - YML048W-A Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 10524 BY4742 13_1 3 B 12 YML037C - - Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene C, F, P biological_process, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function 10534 BY4742 13_2 3 C 1 YML034W SRC1 HEH1|YML033W Inner nuclear membrane (INM) protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence C, F, P cell cycle, endomembrane system, molecular_function, nucleus, organelle organization and biogenesis 10537 BY4742 13_2 3 C 2 YML034C-A - YML035C-A Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 10538 BY4742 13_2 3 C 3 YML034W SRC1 HEH1|YML033W Inner nuclear membrane (INM) protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence C, F, P cell cycle, endomembrane system, molecular_function, nucleus, organelle organization and biogenesis 10539 BY4742 13_2 3 C 4 YML032C RAD52 - Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis C, F, P DNA binding, DNA metabolic process, cell cycle, chromosome, meiosis, nucleus, organelle organization and biogenesis, other, response to stress 10540 BY4742 13_2 3 C 5 YML030W - - Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth rate in minimal glycerol media C, F, P biological_process, mitochondrion, molecular_function 10543 BY4742 13_2 3 C 6 YML029W USA1 - Protein involved in ER-associated protein degradation (ERAD); component of the Hrd1p complex; interacts with the U1 snRNP-specific protein, Snp1p C, F, P RNA metabolic process, cytoplasm, endomembrane system, endoplasmic reticulum, membrane, molecular_function, protein catabolic process 10544 BY4742 13_2 3 C 7 YML028W TSA1 TPX1|ZRG14 Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype C, F, P cellular homeostasis, cytoplasm, other, oxidoreductase activity, protein binding, response to chemical stimulus, response to stress, translation 10545 BY4742 13_2 3 C 8 YML026C RPS18B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation 10547 BY4742 13_2 3 C 9 YML024W RPS17A RPL51A|RP51A Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein C, F, P cytoplasm, organelle organization and biogenesis, ribosome, ribosome biogenesis, structural molecule activity, translation 10549 BY4742 13_2 3 C 10 YML020W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 10553 BY4742 13_2 3 C 11 YML019W OST6 - Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, other, protein modification process, transferase activity 10554 BY4742 13_2 3 C 12 YML018C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene C, F, P biological_process, cytoplasm, membrane, molecular_function, vacuole 10555 BY4742 13_2 3 D 1 YML017W PSP2 MRS15 Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing C, F, P biological_process, cytoplasm, molecular_function 10556 BY4742 13_2 3 D 2 YML016C PPZ1 - Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance C, F, P cellular homeostasis, cytoplasm, hydrolase activity, membrane, nucleus, phosphoprotein phosphatase activity, plasma membrane 10557 BY4742 13_2 3 D 3 YML014W TRM9 KTI1 tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNAs, creating 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu); deletion confers resistance to zymocin C, F, P RNA metabolic process, cytoplasm, nucleus, response to stress, transferase activity 10559 BY4742 13_2 3 D 4 YML013W UBX2 SEL1 Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, mitochondrial envelope, mitochondrion, protein binding, protein catabolic process, transport 10560 BY4742 13_2 3 D 5 YML012C-A - YML013C-A Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1 C, F, P biological_process, cellular_component, molecular_function 10561 BY4742 13_2 3 D 6 YML012W ERV25 - Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function, transport, vesicle-mediated transport 10562 BY4742 13_2 3 D 7 YML011C RAD33 - Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus C, F, P DNA metabolic process, molecular_function, nucleus, response to stress 10563 BY4742 13_2 3 D 8 YML009W-B - YML010W-A Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition C, F, P biological_process, cellular_component, molecular_function 10565 BY4742 13_2 3 D 9 YML009C MRPL39 - Mitochondrial ribosomal protein of the large subunit C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation 10567 BY4742 13_2 3 D 10 YML008C ERG6 VID1|SED6|LIS1|ISE1 Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane C, F, P cytoplasm, endoplasmic reticulum, lipid metabolic process, membrane, mitochondrial envelope, mitochondrion, transferase activity 10568 BY4742 13_2 3 D 11 YML007W YAP1 SNQ3|PAR1 Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium C, F, P DNA binding, RNA metabolic process, cytoplasm, nucleus, response to chemical stimulus, response to stress, transcription, transcription regulator activity 10569 BY4742 13_2 3 D 12 YML006C GIS4 - CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway C, F, P cellular homeostasis, molecular_function, plasma membrane, signal transduction 10570 BY4742 13_2 3 E 1 YML005W TRM12 TYW2 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA C, F, P RNA metabolic process, cytoplasm, transferase activity 10571 BY4742 13_2 3 E 2 YML004C GLO1 - Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress C, F, P cofactor metabolic process, cytoplasm, lyase activity, nucleus, response to chemical stimulus 10572 BY4742 13_2 3 E 3 YML003W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 10573 BY4742 13_2 3 E 4 YML002W - - Putative protein of unknown function; expression induced by heat and by calcium shortage C, F, P biological_process, cellular_component, molecular_function 10574 BY4742 13_2 3 E 5 YMR002W MIC17 - Mitochondrial intermembrane space cysteine motif protein; MIC17 is not an essential gene C, F, P biological_process, cytoplasm, mitochondrial envelope, mitochondrion, molecular_function, nucleus 10577 BY4742 13_2 3 E 6 YMR003W - - Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media C, F, P biological_process, mitochondrion, molecular_function 10578 BY4742 13_2 3 E 7 YMR006C PLB2 - Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine C, F, P cell wall, extracellular region, hydrolase activity, lipid metabolic process 10581 BY4742 13_2 3 E 8 YMR007W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 10582 BY4742 13_2 3 E 9 YMR008C PLB1 - Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol C, F, P cell wall, hydrolase activity, lipid metabolic process 10583 BY4742 13_2 3 E 10 YMR009W ADI1 - Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions C, F, P amino acid and derivative metabolic process, cytoplasm, nucleus, oxidoreductase activity 10584 BY4742 13_2 3 E 11 YMR010W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 C, F, P cytoplasm, molecular_function, other 10585 BY4742 13_2 3 E 12 YMR011W HXT2 - High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose C, F, P membrane fraction, plasma membrane, transport, transporter activity 10586 BY4742 13_2 3 F 1 YMR012W CLU1 TIF31 eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant C, F, P cytoplasm, molecular_function, organelle organization and biogenesis, translation 10587 BY4742 13_2 3 F 2 YMR014W BUD22 - Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern C, F, P anatomical structure morphogenesis, cytokinesis, molecular_function, nucleus, ribosome biogenesis 10589 BY4742 13_2 3 F 3 YMR016C SOK2 - Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors C, F, P DNA binding, nucleus, pseudohyphal growth, transcription regulator activity 10591 BY4742 13_2 3 F 4 YMR017W SPO20 DBI9 Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog C, F, P membrane, protein binding, sporulation 10592 BY4742 13_2 3 F 5 YMR018W - - Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene C, F, P biological_process, cellular_component, molecular_function 10593 BY4742 13_2 3 F 6 YMR019W STB4 - Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters C, F, P DNA binding, biological_process, nucleus 10594 BY4742 13_2 3 F 7 YMR020W FMS1 - Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis C, F, P amino acid and derivative metabolic process, cofactor metabolic process, cytoplasm, oxidoreductase activity 10595 BY4742 13_2 3 F 8 YMR022W UBC7 QRI8 Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly C, F, P endoplasmic reticulum, ligase activity, organelle organization and biogenesis, protein catabolic process 10597 BY4742 13_2 3 F 9 YMR023C MSS1 PET53 Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 C, F, P RNA metabolic process, cytoplasm, membrane, mitochondrial envelope, mitochondrion, other, translation 10598 BY4742 13_2 3 F 10 YMR024W MRPL3 - Mitochondrial ribosomal protein of the large subunit C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation 10599 BY4742 13_2 3 F 11 YMR025W CSI1 - Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling C, F, P conjugation, molecular_function, nucleus, protein modification process, response to chemical stimulus, signal transduction 10600 BY4742 13_2 3 F 12 YMR026C PEX12 PAS11 C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorders C, F, P cytoplasm, membrane, organelle organization and biogenesis, peroxisome, protein binding, transport 10601 BY4742 13_2 3 G 1 YMR027W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus 10602 BY4742 13_2 3 G 2 YMR029C FAR8 - Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p C, F, P cell cycle, cellular_component, conjugation, molecular_function, response to chemical stimulus 10604 BY4742 13_2 3 G 3 YMR030W RSF1 - Protein required for respiratory growth; localized to both the nucleus and mitochondrion; mutant displays decreased transcription of specific nuclear and mitochondrial genes whose products are involved in respiratory growth C, F, P RNA metabolic process, cellular respiration, generation of precursor metabolites and energy, mitochondrion, molecular_function, nucleus, organelle organization and biogenesis, signal transduction, transcription 10605 BY4742 13_2 3 G 4 YMR031W-A - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C C, F, P cellular_component, molecular_function, other 10606 BY4742 13_2 3 G 5 YMR031C - - Protein of unknown function with similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; YMR031C is not an essential gene C, F, P biological_process, cytoplasm, mitochondrion, molecular_function 10607 BY4742 13_2 3 G 6 YMR032W HOF1 CYK2 Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p C, F, P cell cortex, cellular bud, cytokinesis, cytoplasm, cytoskeleton, protein binding, response to stress, site of polarized growth 10608 BY4742 13_2 3 G 7 YMR034C - - Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene C, F, P biological_process, cellular_component, transporter activity 10610 BY4742 13_2 3 G 8 YMR036C MIH1 - Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25 C, F, P cell cycle, cytoplasm, hydrolase activity, nucleus, phosphoprotein phosphatase activity 10612 BY4742 13_2 3 G 9 YMR039C SUB1 TSP1 Transcriptional coactivator, facilitates elongation by influencing enzymes that modify RNAP II, acts in a peroxide resistance pathway involving Rad2p; suppressor of TFIIB mutations C, F, P RNA metabolic process, nucleus, protein binding, transcription, transcription regulator activity 10615 BY4742 13_2 3 G 10 YMR040W YET2 - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein C, F, P biological_process, membrane, molecular_function, ribosome 10616 BY4742 13_2 3 G 11 YMR041C ARA2 - NAD-dependent arabinose dehydrogenase, involved in biosynthesis of erythroascorbic acid; similar to plant L-galactose dehydrogenase C, F, P cellular_component, oxidoreductase activity, vitamin metabolic process 10617 BY4742 13_2 3 G 12 YMR042W ARG80 ARGRI|ARGR1 Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p C, F, P DNA binding, RNA metabolic process, amino acid and derivative metabolic process, nucleus, transcription, transcription regulator activity 10618 BY4742 13_2 3 H 1 YMR044W IOC4 - Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif C, F, P nucleus, organelle organization and biogenesis, protein binding 10620 BY4742 13_2 3 H 2 YMR140W SIP5 - Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase C, F, P cytoplasm, molecular_function, response to stress 10721 BY4742 13_4 3 H 4 YMR141C - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 10722 BY4742 13_4 3 H 5 YMR143W RPS16A - Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins C, F, P cytoplasm, nucleolus, nucleus, ribosome, structural molecule activity, translation 10724 BY4742 13_4 3 H 6 YMR144W - - Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene C, F, P biological_process, molecular_function, nucleus 10725 BY4742 13_4 3 H 7 YMR145C NDE1 NDH1 Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain C, F, P cofactor metabolic process, generation of precursor metabolites and energy, mitochondrion, other, oxidoreductase activity, vitamin metabolic process 10726 BY4742 13_4 3 H 8 YMR147W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 10728 BY4742 13_4 3 H 9 YMR148W - - Putative protein of unknown function; predicted to contain a transmembrane domain; YMR148W is not an essential gene C, F, P biological_process, membrane, molecular_function 10729 BY4742 13_4 3 H 10 YMR153W NUP53 - Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex C, F, P endomembrane system, membrane, nuclear organization and biogenesis, nucleus, organelle organization and biogenesis, structural molecule activity, transport 10734 BY4742 13_4 3 H 11 YMR153C-A - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53 C, F, P biological_process, cellular_component, molecular_function 10735 BY4742 13_4 3 H 12 YMR155W - - Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen C, F, P biological_process, cellular_component, molecular_function 10737 BY4742 13_4 4 A 1 YMR156C TPP1 - DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily C, F, P DNA metabolic process, cellular_component, hydrolase activity, response to stress 10738 BY4742 13_4 4 A 2 YMR157C - FMP39 Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media C, F, P biological_process, mitochondrion, molecular_function 10739 BY4742 13_4 4 A 3 YMR158W-B - YMR158W-A Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C C, F, P biological_process, cellular_component, molecular_function 10741 BY4742 13_4 4 A 5 YMR159C ATG16 APG15|APG16|CVT11|SAP18 Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy C, F, P cytoplasm, ligase activity, membrane fraction, protein binding, response to stress 10742 BY4742 13_4 4 A 6 YMR160W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene C, F, P biological_process, cytoplasm, membrane, molecular_function, vacuole 10743 BY4742 13_4 4 A 7 YMR161W HLJ1 - Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Hdj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, enzyme regulator activity, membrane, other, protein catabolic process, protein folding 10744 BY4742 13_4 4 A 8 YMR162C DNF3 - Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, hydrolase activity, membrane organization and biogenesis, transport, transporter activity 10745 BY4742 13_4 4 A 9 YMR163C INP2 - Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene C, F, P cytoplasm, membrane, organelle organization and biogenesis, peroxisome, protein binding 10746 BY4742 13_4 4 A 10 YMR164C MSS11 - Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals C, F, P RNA metabolic process, carbohydrate metabolic process, nucleus, pseudohyphal growth, transcription, transcription regulator activity 10747 BY4742 13_4 4 A 11 YMR166C - - Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene C, F, P cytoplasm, membrane, mitochondrial envelope, mitochondrion, transport, transporter activity 10749 BY4742 13_4 4 A 12 YMR167W MLH1 PMS2 Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer C, F, P DNA binding, DNA metabolic process, cell cycle, cytoplasm, hydrolase activity, meiosis, mitochondrion, nucleus, other, response to stress 10750 BY4742 13_4 4 B 1 YMR169C ALD3 - Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose C, F, P amino acid and derivative metabolic process, cytoplasm, oxidoreductase activity, response to stress 10752 BY4742 13_4 4 B 2 YMR170C ALD2 - Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p C, F, P amino acid and derivative metabolic process, cytoplasm, other, oxidoreductase activity 10753 BY4742 13_4 4 B 3 YMR172C-A - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 10756 BY4742 13_4 4 B 4 YMR173W-A - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W C, F, P biological_process, cellular_component, molecular_function 10758 BY4742 13_4 4 B 5 YMR174C PAI3 - Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact C, F, P cytoplasm, enzyme regulator activity, protein catabolic process 10759 BY4742 13_4 4 B 6 YMR175W SIP18 - Protein of unknown function whose expression is induced by osmotic stress C, F, P lipid binding, other, response to stress 10760 BY4742 13_4 4 B 7 YMR176W ECM5 - Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks C, F, P cell wall organization and biogenesis, molecular_function, nucleus 10761 BY4742 13_4 4 B 8 YMR177W MMT1 - Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p C, F, P cellular homeostasis, membrane, mitochondrion, molecular_function 10762 BY4742 13_4 4 B 9 YMR178W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus 10763 BY4742 13_4 4 B 10 YMR179W SPT21 - Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; involved in telomere maintenance C, F, P DNA metabolic process, RNA metabolic process, molecular_function, nucleus, transcription, transposition 10764 BY4742 13_4 4 B 11 YMR180C CTL1 CTH1 RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm C, F, P RNA metabolic process, cytoplasm, hydrolase activity, nucleus 10765 BY4742 13_4 4 B 12 YMR182C RGM1 - Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth C, F, P RNA metabolic process, nucleus, transcription, transcription regulator activity 10767 BY4742 13_4 4 C 1 YMR183C SSO2 - Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p C, F, P cytoplasm, endoplasmic reticulum, membrane, membrane fraction, membrane organization and biogenesis, organelle organization and biogenesis, plasma membrane, protein binding, transport, vesicle-mediated transport 10768 BY4742 13_4 4 C 2 YMR184W ADD37 - Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene C, F, P cytoplasm, molecular_function, protein catabolic process 10769 BY4742 13_4 4 C 3 YMR185W - - Putative protein of unknown function; essential gene required for viability C, F, P biological_process, cellular_component, molecular_function 10770 BY4742 13_4 4 C 4 YMR186W HSC82 HSP90 Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock C, F, P cytoplasm, hydrolase activity, mitochondrion, organelle organization and biogenesis, other, protein binding, protein folding, response to stress 10771 BY4742 13_4 4 C 5 YMR187C - - Putative protein of unknown function; YMR187C is not an essential gene C, F, P biological_process, cellular_component, molecular_function 10772 BY4742 13_4 4 C 6 YMR188C MRPS17 - Mitochondrial ribosomal protein of the small subunit C, F, P cellular respiration, cytoplasm, generation of precursor metabolites and energy, mitochondrion, ribosome, structural molecule activity, translation 10773 BY4742 13_4 4 C 7 YMR189W GCV2 GSD2 P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm C, F, P amino acid and derivative metabolic process, cytoplasm, mitochondrion, other, oxidoreductase activity 10774 BY4742 13_4 4 C 8 YMR190C SGS1 - Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes C, F, P DNA metabolic process, cell cycle, chromosome, helicase activity, hydrolase activity, meiosis, nucleolus, organelle organization and biogenesis, other, response to stress 10775 BY4742 13_4 4 C 9 YMR192W GYL1 APP2 Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p C, F, P Golgi apparatus, cellular bud, cytoplasm, cytoplasmic membrane-bounded vesicle, mitochondrion, other, plasma membrane, protein binding, site of polarized growth, transport, vesicle-mediated transport 10777 BY4742 13_4 4 C 10 YMR194W RPL36A RPL39B N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA C, F, P RNA binding, cytoplasm, ribosome, structural molecule activity, translation 10779 BY4742 13_4 4 C 11 YMR193C-A - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 10780 BY4742 13_4 4 C 12 YMR195W ICY1 - Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation C, F, P biological_process, cytoplasm, membrane, molecular_function, vacuole 10781 BY4742 13_4 4 D 1 YMR196W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene C, F, P biological_process, cytoplasm, molecular_function 10782 BY4742 13_4 4 D 2 YMR198W CIK1 - Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p C, F, P cell cycle, conjugation, cytoplasm, cytoskeleton, cytoskeleton organization and biogenesis, meiosis, microtubule organizing center, motor activity, nuclear organization and biogenesis, organelle organization and biogenesis 10784 BY4742 13_4 4 D 3 YMR199W CLN1 - G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) C, F, P cell cycle, cytoplasm, enzyme regulator activity, nucleus 10785 BY4742 13_4 4 D 4 YMR201C RAD14 - Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein C, F, P DNA binding, DNA metabolic process, nucleus, organelle organization and biogenesis, other, response to stress 10787 BY4742 13_4 4 D 5 YMR202W ERG2 END11 C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis C, F, P endoplasmic reticulum, isomerase activity, lipid metabolic process 10788 BY4742 13_4 4 D 6 YMR204C INP1 - Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance C, F, P cytoplasm, membrane, molecular_function, organelle organization and biogenesis, peroxisome 10790 BY4742 13_4 4 D 7 YMR205C PFK2 - Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes C, F, P carbohydrate metabolic process, cytoplasm, generation of precursor metabolites and energy, mitochondrion, transferase activity 10791 BY4742 13_4 4 D 8 YMR206W - - Putative protein of unknown function; YMR206W is not an essential gene C, F, P biological_process, cellular_component, molecular_function 10792 BY4742 13_4 4 D 9 YMR207C HFA1 - Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis C, F, P ligase activity, lipid metabolic process, mitochondrion 10793 BY4742 13_4 4 D 10 YMR210W - - Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification C, F, P cellular_component, lipid metabolic process, transferase activity 10796 BY4742 13_4 4 D 11 YMR214W SCJ1 - One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins C, F, P cytoplasm, endoplasmic reticulum, protein binding, protein catabolic process, protein folding, response to chemical stimulus, response to stress 10800 BY4742 13_4 4 D 12 YMR215W GAS3 - Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall C, F, P biological_process, cell wall, membrane fraction, transferase activity 10801 BY4742 13_4 4 E 1 YMR206C - - - - - 10802 BY4742 13_4 "This must be a typo, this ORF is not found in SGD nor are primers found in deletion project files" 4 E 2 YMR219W ESC1 - Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p C, F, P RNA metabolic process, molecular_function, nucleus, organelle organization and biogenesis, transcription 10805 BY4742 13_4 4 E 3 YMR221C - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy C, F, P biological_process, cytoplasm, mitochondrion, molecular_function, vacuole 10807 BY4742 13_4 4 E 4 YMR222C FSH2 - Serine hydrolase that localizes to the cytoplasm; sequence is similar to Fsh1p and Fsh3p C, F, P biological_process, cytoplasm, hydrolase activity 10808 BY4742 13_4 4 E 5 YMR223W UBP8 - Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B C, F, P hydrolase activity, nucleus, organelle organization and biogenesis, peptidase activity, protein modification process 10809 BY4742 13_4 4 E 6 YMR224C MRE11 NGS1|XRS4|RAD58 Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved C, F, P DNA binding, DNA metabolic process, RNA metabolic process, cell cycle, hydrolase activity, meiosis, mitochondrion, nucleus, protein binding, response to stress, sporulation, transcription, transferase activity 10810 BY4742 13_4 4 E 7 YMR225C MRPL44 YMR44 Mitochondrial ribosomal protein of the large subunit C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation 10811 BY4742 13_4 4 E 8 YMR226C - - NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments C, F, P cytoplasm, nucleus, other, oxidoreductase activity, ribosome 10812 BY4742 13_4 4 E 9 YMR230W RPS10B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10 C, F, P cytoplasm, ribosome, structural molecule activity, translation 10816 BY4742 13_4 4 E 10 YMR232W FUS2 - Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating C, F, P anatomical structure morphogenesis, conjugation, membrane organization and biogenesis, mitochondrion, molecular_function, nucleus, response to chemical stimulus, site of polarized growth 10818 BY4742 13_5 4 E 11 YMR233W TRI1 - Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus C, F, P biological_process, cytoplasm, molecular_function, nucleolus, nucleus 10819 BY4742 13_5 4 E 12 YMR234W RNH1 - Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201) C, F, P RNA metabolic process, cell wall organization and biogenesis, hydrolase activity, nucleus, other 10820 BY4742 13_5 4 F 1 YMR237W BCH1 - Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes C, F, P Golgi apparatus, carbohydrate metabolic process, cell wall organization and biogenesis, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function, ribosome, transport, vesicle-mediated transport 10823 BY4742 13_5 4 F 2 YMR238W DFG5 - Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p C, F, P cell budding, cell wall organization and biogenesis, hydrolase activity, membrane, plasma membrane, pseudohyphal growth 10824 BY4742 13_5 4 F 3 YMR241W YHM2 - Mitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family C, F, P DNA binding, cytoplasm, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, transport, transporter activity 10827 BY4742 13_5 4 F 4 YMR242C RPL20A RPL18A2 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein C, F, P cytoplasm, ribosome, structural molecule activity, translation 10828 BY4742 13_5 4 F 5 YMR243C ZRC1 OSR1 Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm C, F, P cellular homeostasis, cofactor metabolic process, cytoplasm, transport, transporter activity, vacuole 10829 BY4742 13_5 4 F 6 YMR244W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 10830 BY4742 13_5 4 F 7 YMR245W - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 10831 BY4742 13_5 4 F 8 YMR244C-A - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus 10832 BY4742 13_5 4 F 9 YMR246W FAA4 - Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids C, F, P cytoplasm, ligase activity, lipid metabolic process, protein modification process, transport 10833 BY4742 13_5 4 F 10 YMR247C RKR1 - Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential gene C, F, P RNA metabolic process, ligase activity, nucleus, organelle organization and biogenesis, protein modification process, ribosome, transcription 10834 BY4742 13_5 4 F 11 YMR250W GAD1 - Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress C, F, P amino acid and derivative metabolic process, cytoplasm, lyase activity, response to chemical stimulus, response to stress 10835 BY4742 13_5 4 F 12 YMR251W GTO3 - Omega class glutathione transferase; putative cytosolic localization C, F, P cofactor metabolic process, cytoplasm, transferase activity 10836 BY4742 13_5 4 G 1 YMR251W-A HOR7 - Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor C, F, P cell wall, endoplasmic reticulum, membrane fraction, molecular_function, plasma membrane, response to stress 10837 BY4742 13_5 4 G 2 YMR252C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene C, F, P biological_process, mitochondrion, molecular_function 10838 BY4742 13_5 4 G 3 YMR253C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function 10839 BY4742 13_5 4 G 4 YMR254C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 10840 BY4742 13_5 4 G 5 YMR255W GFD1 - Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation C, F, P cytoplasm, endomembrane system, membrane, molecular_function, nucleus, transport 10841 BY4742 13_5 4 G 6 YMR258C - - Protein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus 10844 BY4742 13_5 4 G 7 YMR259C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function 10845 BY4742 13_5 4 G 8 YMR261C TPS3 - Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway C, F, P carbohydrate metabolic process, cytoplasm, enzyme regulator activity, hydrolase activity, response to stress, transferase activity 10847 BY4742 13_5 4 G 9 YMR262W - - Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene C, F, P biological_process, cellular_component, molecular_function 10848 BY4742 13_5 4 G 10 YMR263W SAP30 - Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance C, F, P RNA metabolic process, hydrolase activity, nucleus, organelle organization and biogenesis, protein modification process, transcription 10849 BY4742 13_5 4 G 11 YMR264W CUE1 KIS4 Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, mitochondrion, other, protein binding, protein catabolic process 10850 BY4742 13_5 4 G 12 YMR265C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 10851 BY4742 13_5 4 H 1 YMR269W TMA23 YMR268W-A Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes C, F, P molecular_function, nucleolus, organelle organization and biogenesis, ribosome, ribosome biogenesis 10855 BY4742 13_5 4 H 2 YMR272C SCS7 FAH1 Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth C, F, P endoplasmic reticulum, lipid metabolic process, membrane, oxidoreductase activity 10858 BY4742 13_5 4 H 4 YMR273C ZDS1 OSS1|NRC1|CKM1|CES1 Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of Bcy1p, a regulatory subunit of protein kinase A; implicated in mRNA nuclear export C, F, P RNA metabolic process, anatomical structure morphogenesis, cellular bud, cytoplasm, endomembrane system, membrane, nucleus, organelle organization and biogenesis, other, protein binding, site of polarized growth, transcription, transport 10859 BY4742 13_5 4 H 5 YMR274C RCE1 - Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, hydrolase activity, membrane, peptidase activity, protein modification process 10860 BY4742 13_5 4 H 6 YMR275C BUL1 SMM2|RDS1|DAG1 Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases C, F, P organelle organization and biogenesis, other, plasma membrane, protein binding, protein modification process 10861 BY4742 13_5 4 H 7 YMR276W DSK2 - Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome C, F, P cell cycle, cytoskeleton organization and biogenesis, nucleus, organelle organization and biogenesis, protein binding, protein catabolic process 10862 BY4742 13_5 4 H 8 YMR278W PGM3 - Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential C, F, P biological_process, cytoplasm, isomerase activity, nucleus 10864 BY4742 13_5 4 H 9 YMR280C CAT8 MSP8|DIL1 Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements C, F, P RNA metabolic process, carbohydrate metabolic process, nucleus, transcription, transcription regulator activity 10866 BY4742 13_5 4 H 10 YMR283C RIT1 - 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA C, F, P RNA metabolic process, cytoplasm, protein modification process, transferase activity, translation 10869 BY4742 13_5 4 H 11 YMR284W YKU70 KU70|NES24|HDF1 Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair C, F, P DNA binding, DNA metabolic process, RNA binding, RNA metabolic process, chromosome, endomembrane system, nucleus, organelle organization and biogenesis, response to stress, transcription 10870 BY4742 13_5 4 H 12 YMR285C NGL2 - Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p C, F, P RNA metabolic process, hydrolase activity, organelle organization and biogenesis, other, ribosome biogenesis 10871 BY4742 13_5 5 A 1 YMR289W ABZ2 - Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis C, F, P aromatic compound metabolic process, cofactor metabolic process, cytoplasm, heterocycle metabolic process, lyase activity, vitamin metabolic process 10875 BY4742 13_5 5 A 2 YMR291W - - Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene C, F, P biological_process, cytoplasm, nucleus, protein kinase activity 10878 BY4742 13_5 5 A 3 YMR292W GOT1 - Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2p C, F, P Golgi apparatus, cytoplasm, endomembrane system, membrane, molecular_function, transport, vesicle-mediated transport 10879 BY4742 13_5 5 A 4 YMR294W JNM1 PAC3|INS1 Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B C, F, P cytoskeleton, other, structural molecule activity 10881 BY4742 13_5 5 A 6 YMR294W-A - - Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents C, F, P biological_process, cellular_component, molecular_function 10882 BY4742 13_5 5 A 7 YMR295C - - Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene C, F, P biological_process, cellular bud, molecular_function, ribosome 10883 BY4742 13_5 5 A 8 YMR297W PRC1 LBC1 Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family C, F, P cytoplasm, endoplasmic reticulum, hydrolase activity, other, peptidase activity, protein catabolic process, transferase activity, vacuole 10885 BY4742 13_5 5 A 9 YMR299C DYN3 - Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration C, F, P cytoskeleton, cytoskeleton organization and biogenesis, motor activity, organelle organization and biogenesis, transport 10887 BY4742 13_5 5 A 10 YMR300C ADE4 - Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway C, F, P aromatic compound metabolic process, cytoplasm, heterocycle metabolic process, other, transferase activity 10888 BY4742 13_5 5 A 11 YMR302C YME2 PRP12|RNA12 Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases C, F, P Golgi apparatus, cytoplasm, endomembrane system, membrane, mitochondrial envelope, mitochondrion, molecular_function, organelle organization and biogenesis 10890 BY4742 13_5 5 A 12 YMR303C ADH2 ADR2 Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 C, F, P amino acid and derivative metabolic process, cofactor metabolic process, cytoplasm, generation of precursor metabolites and energy, other, oxidoreductase activity, vitamin metabolic process 10891 BY4742 13_5 5 B 1 YMR304W UBP15 - Ubiquitin-specific protease that may play a role in ubiquitin precursor processing C, F, P cytoplasm, hydrolase activity, peptidase activity, protein modification process 10892 BY4742 13_5 5 B 2 YMR304C-A - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10 C, F, P biological_process, cellular_component, molecular_function 10893 BY4742 13_5 5 B 3 YMR305C SCW10 - Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p C, F, P cell wall, conjugation, cytoplasm, endoplasmic reticulum, hydrolase activity 10894 BY4742 13_5 5 B 4 YMR306C-A - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 10896 BY4742 13_5 5 B 5 YMR307W GAS1 GGP1|CWH52 Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor C, F, P cell wall, cell wall organization and biogenesis, membrane fraction, mitochondrion, other, plasma membrane, transferase activity 10897 BY4742 13_5 5 B 6 YMR310C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene C, F, P molecular_function, nucleus, ribosome biogenesis 10900 BY4742 13_5 5 B 7 YNL339C YRF1-6 YRF1 Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p C, F, P DNA metabolic process, helicase activity, nucleus, organelle organization and biogenesis 11105 BY4742 14_1 5 B 8 YNL338W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV C, F, P biological_process, cellular_component, molecular_function 11106 BY4742 14_1 5 B 9 YNL336W COS1 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins C, F, P biological_process, cytoplasm, molecular_function, vacuole 11108 BY4742 14_1 5 B 10 YNL335W - - Hypothetical protein C, F, P biological_process, cellular_component, molecular_function 11109 BY4742 14_1 5 B 11 YNL334C SNO2 - Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin C, F, P cellular_component, molecular_function, vitamin metabolic process 11110 BY4742 14_1 5 B 12 YNL333W SNZ2 - Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p C, F, P cellular_component, protein binding, vitamin metabolic process 11111 BY4742 14_1 5 C 1 YNL332W THI12 - Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 C, F, P cellular_component, molecular_function, vitamin metabolic process 11112 BY4742 14_1 5 C 2 YNL329C PEX6 PAS8 AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol C, F, P cytoplasm, hydrolase activity, membrane fraction, organelle organization and biogenesis, other, peroxisome, protein binding, signal transduction, transport 11115 BY4742 14_1 5 C 3 YNL328C MDJ2 - Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain C, F, P cytoplasm, enzyme regulator activity, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, transport, transporter activity 11116 BY4742 14_1 5 C 4 YNL327W EGT2 - Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner C, F, P cell wall, cellular bud, cytokinesis, hydrolase activity 11117 BY4742 14_1 5 C 5 YNL326C PFA3 - Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions C, F, P cytoplasm, membrane, membrane organization and biogenesis, organelle organization and biogenesis, protein modification process, transferase activity, vacuole 11118 BY4742 14_1 5 C 6 YNL324W - - Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 11119 BY4742 14_1 5 C 7 YNL325C FIG4 - Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain C, F, P cytoplasm, hydrolase activity, lipid metabolic process, membrane, vacuole 11120 BY4742 14_1 5 C 8 YNL323W LEM3 ROS3|BRE3 Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane C, F, P cytoplasm, endoplasmic reticulum, hydrolase activity, membrane, membrane organization and biogenesis, plasma membrane, signal transduction, transport, transporter activity 11121 BY4742 14_1 5 C 9 YNL322C KRE1 - Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor C, F, P cell wall, cell wall organization and biogenesis, structural molecule activity 11122 BY4742 14_1 5 C 10 YNL321W VNX1 - Low affinity vacuolar membrane localized monovalent cation/H+ antiporter; member of the calcium exchanger (CAX) family; potential Cdc28p substrate C, F, P cytoplasm, transport, transporter activity, vacuole 11123 BY4742 14_1 5 C 11 YNL320W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function 11124 BY4742 14_1 5 C 12 YNL319W - - Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 C, F, P biological_process, cellular_component, molecular_function 11125 BY4742 14_1 5 D 1 YNL318C HXT14 - Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P mitochondrion, plasma membrane, transport, transporter activity 11126 BY4742 14_1 5 D 2 YNL314W DAL82 - Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain C, F, P RNA metabolic process, heterocycle metabolic process, nucleus, transcription, transcription regulator activity 11130 BY4742 14_1 5 D 3 YNL311C - SKP2 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; putative F-box protein; analysis of integrated high-throughput datasets predicts involvement in ubiquitin-dependent protein catabolism C, F, P other, protein binding, protein catabolic process, ribosome 11133 BY4742 14_1 5 D 4 YNL307C MCK1 YPK1 Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family C, F, P DNA metabolic process, cell cycle, meiosis, organelle organization and biogenesis, other, protein kinase activity, protein modification process, response to stress, sporulation, transferase activity 11137 BY4742 14_1 5 D 5 YNL305C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, vacuole 11139 BY4742 14_1 5 D 6 YNL304W YPT11 - Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells C, F, P cellular bud, hydrolase activity, organelle organization and biogenesis, other, site of polarized growth 11140 BY4742 14_1 5 D 7 YNL303W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 11141 BY4742 14_1 5 D 8 YNL302C RPS19B RP55B Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap C, F, P RNA metabolic process, cytoplasm, organelle organization and biogenesis, ribosome, ribosome biogenesis, structural molecule activity, translation, transport 11142 BY4742 14_1 5 D 9 YNL301C RPL18B RP28B Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein C, F, P cytoplasm, ribosome, structural molecule activity, translation 11143 BY4742 14_1 5 D 10 YNL299W TRF5 - Poly (A) polymerase involved in nuclear RNA quality control based on: homology with Trf4p, genetic interactions with TRF4 mutants, physical interaction with Mtr4p (TRAMP subunit), and by direct assay; disputed role as a sigma DNA polymerase C, F, P RNA metabolic process, cell cycle, nucleolus, nucleotidyltransferase activity, nucleus, organelle organization and biogenesis, transferase activity 11145 BY4742 14_1 5 D 11 YNL298W CLA4 ERC10 Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p C, F, P anatomical structure morphogenesis, cell budding, cell cortex, cell cycle, cytokinesis, cytoplasm, cytoskeleton, protein k