mat a Synced to SGD on Fri Aug 1 09:00:51 2008 plate row column ORF Gene Alias Description GO Aspect GO Term record no. strain batch 1 A 2 YAL068C - - Hypothetical protein C, F, P RNA metabolic process, cellular_component, molecular_function, sporulation, transcription 338 BY4741 01_1 1 A 3 YAL067C SEO1 - Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide C, F, P membrane, transport, transporter activity 339 BY4741 01_1 1 A 4 YAL066W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 340 BY4741 01_1 1 A 5 YAL065C - - Putative protein of unknown function; has homology to FLO1; possible pseudogene C, F, P biological_process, cellular_component, molecular_function 341 BY4741 01_1 1 A 6 YAL062W GDH3 FUN51 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources C, F, P amino acid and derivative metabolic process, mitochondrion, nucleus, other, oxidoreductase activity 345 BY4741 01_1 1 A 7 YAL061W BDH2 - Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene C, F, P biological_process, cytoplasm, nucleus, oxidoreductase activity 346 BY4741 01_1 1 A 8 YAL060W BDH1 - NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source C, F, P cytoplasm, other, oxidoreductase activity 347 BY4741 01_1 1 A 9 YAL059W ECM1 - Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export C, F, P cell wall organization and biogenesis, molecular_function, nucleolus, nucleus, organelle organization and biogenesis, ribosome biogenesis, transport 348 BY4741 01_1 1 A 10 YAL058W CNE1 FUN48 Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, protein binding, protein catabolic process, protein folding 349 BY4741 01_1 1 A 11 YAL056W GPB2 KRH1 Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p C, F, P RNA metabolic process, cytoplasm, enzyme regulator activity, mitochondrion, other, plasma membrane, protein binding, pseudohyphal growth, response to chemical stimulus, signal transducer activity, signal transduction, sporulation, transcription 351 BY4741 01_1 1 A 12 YAL055W PEX22 YAF5 Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation C, F, P cytoplasm, membrane, organelle organization and biogenesis, peroxisome, protein binding, signal transduction, transport 352 BY4741 01_1 1 B 1 YAL053W FLC2 HUF2 Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance C, F, P cell wall organization and biogenesis, cytoplasm, endoplasmic reticulum, protein folding, transport, transporter activity 354 BY4741 01_1 1 B 2 YAL051W OAF1 YAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis C, F, P DNA binding, lipid metabolic process, nucleus, organelle organization and biogenesis, response to chemical stimulus, transcription, transcription regulator activity 355 BY4741 01_1 1 B 3 YAL049C - - Cytoplasmic protein of unknown function, potential Hsp82p interactor; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) C, F, P biological_process, cytoplasm, molecular_function 356 BY4741 01_1 1 B 4 YAL048C GEM1 GON1 Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death C, F, P cytoplasm, hydrolase activity, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, vesicle-mediated transport 357 BY4741 01_1 1 B 5 YAL046C - - Putative protein of unknown function; null mutant displays increased frequency of mitochondrial genome loss (petite formation) C, F, P biological_process, cellular_component, molecular_function 359 BY4741 01_1 1 B 6 YAL045C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A C, F, P biological_process, cellular_component, molecular_function 360 BY4741 01_1 1 B 7 YAL044C GCV3 - H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm C, F, P amino acid and derivative metabolic process, cytoplasm, mitochondrion, other, oxidoreductase activity 361 BY4741 01_1 1 B 8 YAL042W ERV46 FUN9 Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, endomembrane system, endoplasmic reticulum, membrane, molecular_function, transport, vesicle-mediated transport 363 BY4741 01_1 1 B 9 YAL043C-a - - - - - 364 BY4741 01_1 1 B 10 YAL040C CLN3 WHI1|FUN10|DAF1 G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis C, F, P cell cycle, enzyme regulator activity, membrane organization and biogenesis, nucleus, organelle organization and biogenesis, other 366 BY4741 01_1 1 B 11 YAL039C CYC3 - Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS) C, F, P cytoplasm, lyase activity, mitochondrial envelope, mitochondrion, protein modification process 367 BY4741 01_1 1 B 12 YAL037W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 369 BY4741 01_1 1 C 1 YAL036C RBG1 FUN11 Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46p C, F, P cytoplasm, other, ribosome biogenesis 370 BY4741 01_1 1 C 2 YAL035W FUN12 yIF2 GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2 C, F, P cytoplasm, hydrolase activity, mitochondrion, ribosome, translation, translation regulator activity 371 BY4741 01_1 1 C 3 YAL034C FUN19 - Non-essential protein of unknown function C, F, P biological_process, cellular_component, molecular_function 374 BY4741 01_1 1 C 4 YAL031C GIP4 FUN21 Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate C, F, P cytoplasm, enzyme regulator activity, other, protein binding 377 BY4741 01_1 1 C 5 YAL030W SNC1 - Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, membrane, membrane organization and biogenesis, organelle organization and biogenesis, protein binding, transport, vesicle-mediated transport 378 BY4741 01_1 1 C 6 YAL029C MYO4 SHE1|FUN22 One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p C, F, P DNA metabolic process, cellular bud, cytoskeleton, mitochondrion, motor activity, organelle organization and biogenesis, other, protein binding 379 BY4741 01_1 1 C 7 YAL028W FRT2 HPH2 Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate C, F, P endoplasmic reticulum, molecular_function, response to stress 380 BY4741 01_1 1 C 8 YAL027W SAW1 - Catalyzes 3'-nonhomologous tail removal of Rad1p/Rad10p-dependent single-strand annealing recombination intermediates; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene C, F, P biological_process, molecular_function, nucleus 381 BY4741 01_1 1 C 9 YAL026C DRS2 SWA3|FUN38 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease C, F, P Golgi apparatus, cytoplasm, hydrolase activity, membrane organization and biogenesis, organelle organization and biogenesis, ribosome biogenesis, transport, transporter activity, vesicle-mediated transport 382 BY4741 01_1 1 C 10 YAL023C PMT2 FUN25 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals C, F, P endoplasmic reticulum, protein modification process, transferase activity 385 BY4741 01_1 1 C 11 YAL022C FUN26 - Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes C, F, P membrane, other, transport, transporter activity 386 BY4741 01_1 1 C 12 YAL021C CCR4 NUT21|FUN27 Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening C, F, P DNA metabolic process, RNA metabolic process, cell cycle, cytoplasm, hydrolase activity, nucleus, response to chemical stimulus, transcription 387 BY4741 01_1 1 D 1 YAL020C ATS1 KTI13|FUN28 Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle C, F, P RNA metabolic process, cell budding, cytoplasm, cytoskeleton organization and biogenesis, molecular_function, organelle organization and biogenesis 388 BY4741 01_1 1 D 2 YAL019W FUN30 - Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P mitochondrion, molecular_function, nucleus, organelle organization and biogenesis 389 BY4741 01_1 1 D 3 YAL018C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 390 BY4741 01_1 1 D 4 YAL017W PSK1 FUN31 One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status C, F, P carbohydrate metabolic process, cell wall organization and biogenesis, cytoplasm, protein kinase activity, protein modification process, transferase activity 391 BY4741 01_1 1 D 5 YAL015C NTG1 SCR1|FUN33 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion C, F, P DNA metabolic process, hydrolase activity, lyase activity, mitochondrion, nucleus, response to stress 393 BY4741 01_1 1 D 6 YAL014C SYN8 SLT2|UIP2 Endosomal SNARE related to mammalian syntaxin 8 C, F, P cytoplasm, protein binding, transport 394 BY4741 01_1 1 D 7 YAL013W DEP1 FUN54 Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation C, F, P RNA metabolic process, hydrolase activity, lipid metabolic process, nucleus, organelle organization and biogenesis, protein modification process, transcription, transcription regulator activity 395 BY4741 01_1 1 D 8 YAL011W SWC3 SWC1 Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae C, F, P mitochondrion, molecular_function, nucleus, organelle organization and biogenesis, response to chemical stimulus 397 BY4741 01_1 1 D 9 YAL010C MDM10 FUN37 Subunit of both the Mdm10-Mdm12-Mmm1 complex and the mitochondrial sorting and assembly machinery (SAM complex); functions in both the general and Tom40p-specific pathways for import and assembly of outer membrane beta-barrel proteins C, F, P cytoplasm, membrane, membrane organization and biogenesis, mitochondrial envelope, mitochondrion, molecular_function, organelle organization and biogenesis, other, transport 398 BY4741 01_1 1 D 10 YAL009W SPO7 - Regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation C, F, P endomembrane system, meiosis, membrane, nuclear organization and biogenesis, phosphoprotein phosphatase activity, sporulation 399 BY4741 01_1 1 D 11 YAL008W FUN14 - Mitochondrial protein of unknown function C, F, P biological_process, cytoplasm, membrane, mitochondrial envelope, mitochondrion, molecular_function 400 BY4741 01_1 1 D 12 YAL007C ERP2 - Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function, transport, vesicle-mediated transport 401 BY4741 01_1 1 E 1 YAL004W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C C, F, P biological_process, cellular_component, molecular_function 402 BY4741 01_1 1 E 2 YAL005C SSA1 YG100 ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall C, F, P cell wall, cytoplasm, hydrolase activity, membrane, nucleus, organelle organization and biogenesis, protein binding, protein folding, response to stress, translation, transport, vacuole 403 BY4741 01_1 1 E 3 YAL002W VPS8 VPT8|FUN15 Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif C, F, P cytoplasm, membrane fraction, molecular_function, transport, vesicle-mediated transport 405 BY4741 01_1 1 E 4 YAR002W NUP60 - Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance C, F, P endomembrane system, membrane, nucleus, structural molecule activity, transport 407 BY4741 01_1 1 E 5 YAR003W SWD1 SAF49|CPS50|FUN16 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 C, F, P RNA metabolic process, nucleus, organelle organization and biogenesis, protein modification process, transcription, transferase activity 408 BY4741 01_1 1 E 6 YAR014C BUD14 - Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern C, F, P RNA metabolic process, anatomical structure morphogenesis, cellular bud, cytoskeleton organization and biogenesis, enzyme regulator activity, other, site of polarized growth, transcription 413 BY4741 01_1 1 E 7 YAR015W ADE1 - N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine C, F, P cytoplasm, ligase activity, nucleus, other, response to chemical stimulus 414 BY4741 01_1 1 E 8 YAR018C KIN3 NPK1|FUN52 Nonessential protein kinase with unknown cellular role C, F, P cellular_component, other, protein kinase activity 415 BY4741 01_1 1 E 9 YAR020C PAU7 - Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme C, F, P biological_process, cellular_component, molecular_function 417 BY4741 01_1 1 E 10 YAR023C - - Putative integral membrane protein, member of DUP240 gene family C, F, P biological_process, cellular_component, molecular_function 418 BY4741 01_1 1 E 11 YAR027W UIP3 - Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family C, F, P biological_process, endomembrane system, molecular_function, nucleus 419 BY4741 01_1 1 E 12 YAR028W - - Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS C, F, P biological_process, cellular_component, molecular_function 420 BY4741 01_1 1 F 1 YAR029W - - Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern C, F, P biological_process, cytoplasm, molecular_function 421 BY4741 01_1 1 F 2 YAR031W PRM9 - Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family C, F, P endoplasmic reticulum, membrane, molecular_function, organelle organization and biogenesis, plasma membrane, response to chemical stimulus 422 BY4741 01_1 1 F 3 YAR030C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 C, F, P biological_process, cellular_component, molecular_function 423 BY4741 01_1 1 F 4 YAR035W YAT1 - Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated C, F, P amino acid and derivative metabolic process, mitochondrion, other, transferase activity, vitamin metabolic process 425 BY4741 01_1 1 F 5 YAR037W - - - - - 426 BY4741 01_1 1 F 6 YAR040C - - - - - 427 BY4741 01_1 1 F 7 YAR042W SWH1 OSH1|YAR044W Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction C, F, P Golgi apparatus, anatomical structure morphogenesis, cytoplasm, endomembrane system, endoplasmic reticulum, lipid binding, membrane organization and biogenesis, nucleus, transport, vesicle-mediated transport 428 BY4741 01_1 1 F 8 YAR043C - - - - - 429 BY4741 01_1 1 F 9 YAR044W - - - - - 430 BY4741 01_1 1 F 10 YAR047C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 431 BY4741 01_1 1 F 11 YLL001W DNM1 - Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology, assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis C, F, P cytoplasm, hydrolase activity, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, other, protein binding 1489 BY4741 12_1 1 F 12 YLL002W RTT109 REM50|KIM2 Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in non-homologous end-joining and in regulation of Ty1 transposition; interacts physically with Vps75p C, F, P DNA metabolic process, nucleus, organelle organization and biogenesis, protein modification process, response to stress, transferase activity, transposition 1490 BY4741 12_1 1 G 1 YLL005C SPO75 - Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis C, F, P cell wall organization and biogenesis, cellular_component, molecular_function, sporulation 1493 BY4741 12_1 1 G 2 YLL006W MMM1 YME6 Mitochondrial outer membrane protein, component of the Mdm10-Mdm12-Mmm1 complex involved in import and assembly of outer membrane beta-barrel proteins C, F, P cytoplasm, membrane, membrane organization and biogenesis, mitochondrial envelope, mitochondrion, molecular_function, organelle organization and biogenesis, transport 1494 BY4741 12_1 1 G 3 YLL009C COX17 - Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase C, F, P cytoplasm, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, other, oxidoreductase activity, transport 1497 BY4741 12_1 1 G 4 YLL010C PSR1 - Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p C, F, P phosphoprotein phosphatase activity, plasma membrane, response to stress 1498 BY4741 12_1 1 G 5 YLL012W YEH1 - Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes C, F, P cytoplasm, hydrolase activity, lipid metabolic process, membrane 1500 BY4741 12_1 1 G 6 YLL013C PUF3 - Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins C, F, P RNA binding, RNA metabolic process, cellular respiration, cytoplasm, generation of precursor metabolites and energy, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, other 1501 BY4741 12_1 1 G 7 YLL014W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLL014W is not an essential gene C, F, P biological_process, endoplasmic reticulum, molecular_function 1502 BY4741 12_1 1 G 8 YLL015W BPT1 - ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p C, F, P cytoplasm, membrane, transport, transporter activity, vacuole 1503 BY4741 12_1 1 G 9 YLL016W - - - - - 1504 BY4741 12_1 1 G 10 YLL017W - - - - - 1505 BY4741 12_1 1 G 11 YLL019C KNS1 L124 Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues C, F, P cellular_component, protein kinase activity, protein modification process, transferase activity 1507 BY4741 12_1 1 G 12 YLL020C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1 C, F, P biological_process, cellular_component, molecular_function 1508 BY4741 12_1 1 H 1 YLL021W SPA2 PEA1|FUS6 Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate C, F, P anatomical structure morphogenesis, cell budding, cell cortex, cellular bud, conjugation, cytokinesis, cytoplasm, cytoskeleton organization and biogenesis, organelle organization and biogenesis, other, protein binding, pseudohyphal growth, response to chemical stimulus, signal transduction, site of polarized growth 1509 BY4741 12_1 1 H 3 YLL023C - - Protein of unknown function; highly conserved across species and orthologous to human TMEM33; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the endoplasmic reticulum C, F, P biological_process, endoplasmic reticulum, molecular_function, ribosome 1511 BY4741 12_1 1 H 4 YLL024C SSA2 YG102 ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall C, F, P cell wall, cytoplasm, hydrolase activity, membrane, mitochondrion, other, protein binding, protein folding, response to stress, transport, vacuole 1512 BY4741 12_1 1 H 5 YLL025W - - Putative protein of unknown function; YLL025W is not an essential gene C, F, P biological_process, cellular_component, molecular_function 1513 BY4741 12_1 1 H 6 YLL026W HSP104 - Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation C, F, P cytoplasm, hydrolase activity, nucleus, protein binding, protein folding, response to stress 1514 BY4741 12_1 1 H 7 YLL028W TPO1 - Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane C, F, P cellular bud, cytoplasm, membrane, plasma membrane, transport, transporter activity, vacuole 1516 BY4741 12_1 1 H 8 YLL029W FRA1 RUP2 Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation C, F, P RNA metabolic process, cytoplasm, molecular_function, response to chemical stimulus, transcription 1517 BY4741 12_1 1 H 9 YLL032C - - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, ribosome 1520 BY4741 12_1 1 H 10 YLL033W IRC19 GON2 Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci C, F, P DNA metabolic process, cellular_component, molecular_function, sporulation 1521 BY4741 12_1 1 H 11 YLL038C ENT4 - Protein of unknown function, contains an N-terminal epsin-like domain C, F, P cell cortex, cytoplasm, cytoskeleton, cytoskeleton organization and biogenesis, membrane organization and biogenesis, organelle organization and biogenesis, protein binding, transport, vesicle-mediated transport 1526 BY4741 12_1 1 H 12 YLL039C UBI4 UB14|SCD2 Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats C, F, P cytoplasm, other, protein binding, protein modification process, response to stress, sporulation 1527 BY4741 12_1 2 A 1 YLL040C VPS13 VPT2|SOI1 Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention C, F, P cytoplasm, membrane, mitochondrion, molecular_function, other, protein catabolic process, sporulation, transport, vesicle-mediated transport 1528 BY4741 12_1 2 A 3 YLL041C SDH2 ACN17 Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone C, F, P cellular respiration, cofactor metabolic process, cytoplasm, generation of precursor metabolites and energy, membrane, mitochondrial envelope, mitochondrion, oxidoreductase activity 1529 BY4741 12_1 2 A 4 YLL042C ATG10 APG10 Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy C, F, P cellular_component, ligase activity, protein modification process, response to stress, transport 1530 BY4741 12_1 2 A 5 YLL043W FPS1 - Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress C, F, P conjugation, cytoplasm, plasma membrane, response to chemical stimulus, transport, transporter activity, vacuole 1531 BY4741 12_1 2 A 6 YLL045C RPL8B SCL41|KRB1 Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits C, F, P cytoplasm, ribosome, structural molecule activity, translation 1533 BY4741 12_1 2 A 7 YLL046C RNP1 - Ribonucleoprotein that contains two RNA recognition motifs (RRM) C, F, P RNA binding, cytoplasm, ribosome biogenesis 1534 BY4741 12_1 2 A 8 YLL047W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1 C, F, P biological_process, cellular_component, molecular_function 1535 BY4741 12_1 2 A 9 YLL051C FRE6 - Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels C, F, P cellular homeostasis, cytoplasm, membrane, oxidoreductase activity, transport, vacuole 1539 BY4741 12_1 2 A 10 YLL052C AQY2 - Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, plasma membrane, transport, transporter activity 1540 BY4741 12_1 2 A 11 YLL053C - - Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin C, F, P biological_process, cellular_component, molecular_function 1541 BY4741 12_1 2 A 12 YLL054C - - Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene C, F, P biological_process, plasma membrane, transcription regulator activity 1542 BY4741 12_1 2 B 1 YLL055W YCT1 - High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene C, F, P endoplasmic reticulum, transport, transporter activity 1543 BY4741 12_1 2 B 2 YLL056C - - Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene C, F, P cellular_component, molecular_function, response to chemical stimulus 1544 BY4741 12_1 2 B 3 YLL057C JLP1 - Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) C, F, P cellular_component, other, oxidoreductase activity 1545 BY4741 12_1 2 B 4 YLL058W - - Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene C, F, P cellular_component, other, transferase activity 1546 BY4741 12_1 2 B 5 YLL060C GTT2 - Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p C, F, P cofactor metabolic process, mitochondrion, response to chemical stimulus, transferase activity 1548 BY4741 12_1 2 B 6 YLL061W MMP1 - High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p C, F, P plasma membrane, transport, transporter activity 1549 BY4741 12_1 2 B 7 YLL062C MHT1 - S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio C, F, P amino acid and derivative metabolic process, cytoplasm, transferase activity 1550 BY4741 12_1 2 B 8 YLL063C AYT1 - Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis C, F, P cellular_component, other, transferase activity 1551 BY4741 12_1 2 B 9 YLR001C - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR001C is not an essential gene C, F, P biological_process, cytoplasm, membrane, mitochondrion, molecular_function, vacuole 1556 BY4741 12_1 2 B 10 YLR003C - CMS1 Putative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene C, F, P DNA metabolic process, cytoplasm, molecular_function, nucleolus, nucleus, ribosome biogenesis 1558 BY4741 12_1 2 B 11 YLR004C THI73 - Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs C, F, P endoplasmic reticulum, membrane, transport, transporter activity 1559 BY4741 12_1 2 B 12 YLR011W LOT6 - FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature C, F, P cytoplasm, nucleus, oxidoreductase activity, response to chemical stimulus, response to stress 1566 BY4741 12_1 2 C 1 YLR012C - - Putative protein of unknown function; YLR012C is not an essential gene C, F, P biological_process, cellular_component, molecular_function 1567 BY4741 12_1 2 C 2 YLR013W GAT3 - Protein containing GATA family zinc finger motifs C, F, P DNA binding, nucleus, transcription, transcription regulator activity 1568 BY4741 12_1 2 C 3 YLR014C PPR1 - Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p C, F, P DNA binding, RNA metabolic process, aromatic compound metabolic process, heterocycle metabolic process, nucleus, transcription, transcription regulator activity 1569 BY4741 12_1 2 C 4 YLR015W BRE2 CPS60 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L C, F, P RNA metabolic process, nucleus, organelle organization and biogenesis, protein modification process, transcription, transcription regulator activity, transferase activity 1570 BY4741 12_1 2 C 5 YLR016C PML1 - Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p C, F, P RNA metabolic process, cytoplasm, molecular_function, nucleus, transport 1571 BY4741 12_1 2 C 6 YLR017W MEU1 - Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression C, F, P amino acid and derivative metabolic process, cytoplasm, transferase activity 1572 BY4741 12_1 2 C 7 YLR018C POM34 - Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex C, F, P endomembrane system, membrane, molecular_function, nucleus, transport 1573 BY4741 12_1 2 C 8 YLR019W PSR2 - Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p C, F, P phosphoprotein phosphatase activity, plasma membrane, response to stress 1574 BY4741 12_1 2 C 9 YLR020C YEH2 - Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism C, F, P cell wall organization and biogenesis, hydrolase activity, lipid metabolic process, membrane, plasma membrane 1575 BY4741 12_1 2 C 10 YLR021W IRC25 DMP2|PBA3|POC3 Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions C, F, P molecular_function, other 1576 BY4741 12_1 2 C 11 YLR023C IZH3 - Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity C, F, P cellular homeostasis, endoplasmic reticulum, lipid metabolic process, membrane, other 1578 BY4741 12_1 2 C 12 YLR024C UBR2 - Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex C, F, P cytoplasm, ligase activity, protein modification process 1579 BY4741 12_1 Incorrect 2 D 1 YLR025W SNF7 RNS4|VPS32|DID1 One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes C, F, P cytoplasm, membrane, protein binding, protein catabolic process, transport, vesicle-mediated transport 1580 BY4741 12_1 2 D 2 YLR027C AAT2 ASP5 Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells C, F, P amino acid and derivative metabolic process, cytoplasm, peroxisome, transferase activity 1582 BY4741 12_1 2 D 3 YLR028C ADE16 - Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine C, F, P cellular respiration, cytoplasm, generation of precursor metabolites and energy, hydrolase activity, other, sporulation, transferase activity 1583 BY4741 12_1 2 D 4 YLR042C - - Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene C, F, P biological_process, cell wall, molecular_function 2653 BY4741 12_2 2 D 5 YLR043C TRX1 LMA1 Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance C, F, P DNA metabolic process, cellular homeostasis, cytoplasm, membrane organization and biogenesis, organelle organization and biogenesis, other, oxidoreductase activity, response to chemical stimulus, response to stress, transport, vacuole, vesicle-mediated transport 2654 BY4741 12_2 2 D 6 YLR044C PDC1 - Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism C, F, P amino acid and derivative metabolic process, aromatic compound metabolic process, cytoplasm, generation of precursor metabolites and energy, heterocycle metabolic process, lyase activity, nucleus, other 2655 BY4741 12_2 2 D 7 YLR046C - RLA1 Putative membrane protein, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance C, F, P biological_process, membrane, molecular_function 2657 BY4741 12_2 2 D 8 YLR047C FRE8 - Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p C, F, P cellular homeostasis, membrane, oxidoreductase activity 2658 BY4741 12_2 2 D 9 YLR048W RPS0B YST2|NAB1B Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal C, F, P cytoplasm, organelle organization and biogenesis, ribosome, ribosome biogenesis, structural molecule activity, translation 2659 BY4741 12_2 2 D 10 YLR049C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 2660 BY4741 12_2 2 D 11 YLR053C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 2664 BY4741 12_2 2 D 12 YLR054C OSW2 - Protein of unknown function proposed to be involved in the assembly of the spore wall C, F, P cell wall organization and biogenesis, cytoplasm, membrane, molecular_function, sporulation 2665 BY4741 12_2 2 E 1 YLR055C SPT8 - Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters C, F, P RNA metabolic process, nucleus, protein binding, transcription, transcription regulator activity 2666 BY4741 12_2 2 E 2 YLR056W ERG3 PSO6|SYR1 C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources C, F, P endoplasmic reticulum, lipid metabolic process, membrane organization and biogenesis, oxidoreductase activity, transport, vesicle-mediated transport 2667 BY4741 12_2 2 E 3 YLR057W - - Putative protein of unknown function; YLR050C is not an essential gene C, F, P biological_process, cellular_component, molecular_function 2668 BY4741 12_2 2 E 4 YLR058C SHM2 SHMT2 Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis C, F, P cytoplasm, other, transferase activity 2669 BY4741 12_2 2 E 5 YLR059C REX2 YNT20 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease C, F, P RNA metabolic process, hydrolase activity, mitochondrion, organelle organization and biogenesis, ribosome biogenesis 2670 BY4741 12_2 2 E 6 YLR061W RPL22A - Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein C, F, P cytoplasm, ribosome, structural molecule activity, translation 2672 BY4741 12_2 2 E 7 YLR062C BUD28 - Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay C, F, P anatomical structure morphogenesis, cellular_component, cytokinesis, molecular_function 2673 BY4741 12_2 2 E 8 YLR063W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene C, F, P biological_process, cytoplasm, molecular_function 2674 BY4741 12_2 2 E 9 YLR064W - - Putative protein of unknown function; highly conserved across species and orthologous to human TMEM33; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR064W is not an essential gene C, F, P biological_process, endoplasmic reticulum, molecular_function 2675 BY4741 12_2 2 E 10 YLR065C - - Putative protein of unknown function; YLR065C is not an essential gene C, F, P biological_process, cellular_component, molecular_function 2676 BY4741 12_2 2 E 11 YLR067C PET309 - Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs) C, F, P RNA metabolic process, cellular respiration, cytoplasm, generation of precursor metabolites and energy, membrane, mitochondrial envelope, mitochondrion, translation, translation regulator activity 2678 BY4741 12_2 2 E 12 YLR068W FYV7 - Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin C, F, P RNA metabolic process, molecular_function, nucleolus, nucleus, organelle organization and biogenesis, ribosome biogenesis 2679 BY4741 12_2 2 F 1 YLR069C MEF1 - Mitochondrial elongation factor involved in translational elongation C, F, P mitochondrion, translation, translation regulator activity 2680 BY4741 12_2 2 F 2 YLR070C XYL2 - Xylitol dehydrogenase, converts xylitol to D-xylulose in the endogenous xylose utilization pathway C, F, P carbohydrate metabolic process, cellular_component, oxidoreductase activity 2681 BY4741 12_2 2 F 3 YLR072W - - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene C, F, P biological_process, cytoplasm, molecular_function 2683 BY4741 12_2 2 F 4 YLR073C - - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes; YLR073C is not an esssential gene C, F, P biological_process, cytoplasm, molecular_function 2684 BY4741 12_2 2 F 5 YLR074C BUD20 - Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern C, F, P anatomical structure morphogenesis, cytokinesis, molecular_function, nucleus, ribosome biogenesis 2685 BY4741 12_2 2 F 6 YLR077W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function 2688 BY4741 12_2 2 F 7 YLR079W SIC1 SDB25 Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 C, F, P DNA metabolic process, cell cycle, cytoplasm, enzyme regulator activity, nucleus, transposition 2690 BY4741 12_2 2 F 8 YLR080W EMP46 - Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, endomembrane system, membrane, protein binding, transport, vesicle-mediated transport 2691 BY4741 12_2 2 F 9 YLR081W GAL2 - Galactose permease, required for utilization of galactose; also able to transport glucose C, F, P carbohydrate metabolic process, plasma membrane, transport, transporter activity 2692 BY4741 12_2 2 F 10 YLR082C SRL2 - Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation C, F, P cytoplasm, molecular_function, nucleus, other 2693 BY4741 12_2 2 F 11 YLR083C EMP70 TMN1|p24a Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions C, F, P cytoplasm, molecular_function, other, pseudohyphal growth 2694 BY4741 12_2 2 F 12 YLR084C RAX2 - N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p C, F, P anatomical structure morphogenesis, cell wall, cellular bud, cytokinesis, membrane, mitochondrion, molecular_function, site of polarized growth 2695 BY4741 12_2 2 G 1 YLR085C ARP6 - Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A C, F, P cytoplasm, nucleus, organelle organization and biogenesis, other 2696 BY4741 12_2 2 G 2 YLR087C CSF1 - Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P generation of precursor metabolites and energy, mitochondrion, molecular_function 2698 BY4741 12_2 2 G 3 YLR089C ALT1 - Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, transferase activity 2700 BY4741 12_2 2 G 4 YLR090W XDJ1 - Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P Golgi apparatus, cytoplasm, endomembrane system, membrane, mitochondrial envelope, mitochondrion, nucleus, other, protein folding 2701 BY4741 12_2 2 G 5 YLR091W - - Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR091W is not an esssential gene C, F, P biological_process, mitochondrion, molecular_function 2702 BY4741 12_2 2 G 6 YLR092W SUL2 - High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates C, F, P plasma membrane, transport, transporter activity 2703 BY4741 12_2 2 G 7 YLR093C NYV1 MAM2 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane C, F, P cytoplasm, membrane, membrane organization and biogenesis, organelle organization and biogenesis, protein binding, transport, vacuole, vesicle-mediated transport 2704 BY4741 12_2 2 G 8 YLR094C GIS3 - Protein of unknown function C, F, P cytoplasm, molecular_function, nucleus, signal transduction 2705 BY4741 12_2 2 G 9 YLR095C IOC2 - Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif C, F, P nucleus, organelle organization and biogenesis, protein binding 2706 BY4741 12_2 2 G 10 YLR096W KIN2 - Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p C, F, P plasma membrane, protein kinase activity, protein modification process, transferase activity, transport, vesicle-mediated transport 2707 BY4741 12_2 2 G 11 YLR097C HRT3 - Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies C, F, P ligase activity, other, protein catabolic process, protein modification process 2708 BY4741 12_2 2 G 12 YLR098C CHA4 SIL3|SIL2 DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain C, F, P DNA binding, RNA metabolic process, amino acid and derivative metabolic process, nucleus, transcription, transcription regulator activity 2709 BY4741 12_2 2 H 1 YLR099C ICT1 - Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress C, F, P cellular_component, lipid metabolic process, transferase activity 2710 BY4741 12_2 2 H 3 YLR102C APC9 - Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition C, F, P cell cycle, cytoskeleton organization and biogenesis, ligase activity, nucleus, organelle organization and biogenesis, protein binding, protein catabolic process, protein modification process 2713 BY4741 12_2 2 H 4 YLR104W - - Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate C, F, P biological_process, cellular_component, molecular_function 2715 BY4741 12_2 2 H 5 YLR107W REX3 - RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases C, F, P RNA metabolic process, cytoplasm, hydrolase activity, nucleus, organelle organization and biogenesis, ribosome biogenesis 2718 BY4741 12_2 2 H 6 YLR108C - - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene C, F, P biological_process, molecular_function, nucleus 2719 BY4741 12_2 2 H 7 YLR109W AHP1 - Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p C, F, P cellular homeostasis, cytoplasm, oxidoreductase activity, response to chemical stimulus, response to stress 2720 BY4741 12_2 2 H 8 YLR111W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 2722 BY4741 12_2 2 H 9 YLR112W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 2723 BY4741 12_2 2 H 10 YLR113W HOG1 SSK3 Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p C, F, P RNA metabolic process, cytoplasm, nucleus, protein kinase activity, protein modification process, response to chemical stimulus, response to stress, signal transducer activity, signal transduction, transcription, transferase activity 2724 BY4741 12_2 2 H 11 YLR114C AVL9 - Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms C, F, P cytoplasm, molecular_function, transport, vesicle-mediated transport 2725 BY4741 12_2 2 H 12 YLR118C - APT1 Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS C, F, P biological_process, cytoplasm, hydrolase activity, nucleus 2729 BY4741 12_2 3 A 1 YLR119W SRN2 VPS37|SRN10 Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus C, F, P cytoplasm, membrane, protein binding, protein catabolic process, transport 2730 BY4741 12_2 3 A 2 YLR120C YPS1 YAP3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor C, F, P cell wall, hydrolase activity, peptidase activity, protein modification process 2731 BY4741 12_2 3 A 4 YLR121C YPS3 YPS4 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor C, F, P cell wall organization and biogenesis, hydrolase activity, membrane, other, peptidase activity, plasma membrane, structural molecule activity 2732 BY4741 12_2 3 A 5 YLR122C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C C, F, P biological_process, cellular_component, molecular_function 2733 BY4741 12_2 3 A 6 YLR123C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif C, F, P biological_process, cellular_component, molecular_function 2734 BY4741 12_2 3 A 7 YLR124W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 2735 BY4741 12_2 3 A 8 YLR125W - - Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene C, F, P biological_process, cellular_component, molecular_function 2736 BY4741 12_2 Incorrect 3 A 9 YML089C - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage C, F, P biological_process, cellular_component, molecular_function 481 BY4730 13_1 3 A 10 YML088W UFO1 - F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation C, F, P cytoplasm, ligase activity, nucleus, other, protein binding, protein catabolic process, response to stress 482 BY4730 13_1 3 A 11 YML087C - - Putative protein of unknown function; highly conserved across species and orthologous to human CYB5R4; null mutant shows increased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media C, F, P biological_process, cellular_component, molecular_function 483 BY4730 13_1 3 A 12 YML086C ALO1 - D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of D-erythroascorbic acid, which is protective against oxidative stress C, F, P Golgi apparatus, cytoplasm, endomembrane system, membrane, mitochondrial envelope, mitochondrion, oxidoreductase activity, response to chemical stimulus, response to stress 484 BY4730 13_1 3 B 1 YML084W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 486 BY4730 13_1 3 B 2 YML083C - - Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions C, F, P biological_process, cellular_component, molecular_function 487 BY4730 13_1 3 B 3 YML082W - - Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene C, F, P cytoplasm, lyase activity, nucleus, other 488 BY4730 13_1 3 B 4 YML081W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene C, F, P biological_process, molecular_function, nucleus 489 BY4730 13_1 3 B 5 YML080W DUS1 - Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 C, F, P RNA metabolic process, nucleus, oxidoreductase activity 490 BY4730 13_1 3 B 6 YML079W - - Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm C, F, P biological_process, cytoplasm, molecular_function, nucleus 491 BY4730 13_1 3 B 7 YML078W CPR3 CYP3 Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria C, F, P isomerase activity, mitochondrion, other, protein folding 492 BY4730 13_1 3 B 8 YML063W RPS1B RP10B|PLC2 Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein C, F, P cytoplasm, nucleolus, nucleus, ribosome, structural molecule activity, translation 507 BY4741 13_1 3 B 9 YML062C MFT1 MFT52 Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance C, F, P DNA metabolic process, RNA metabolic process, nucleus, other, transcription, transport 508 BY4741 13_1 3 B 10 YML061C PIF1 TST1 DNA helicase involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; also plays a role in repair and recombination of mitochondrial DNA C, F, P DNA metabolic process, helicase activity, mitochondrion, nucleus, organelle organization and biogenesis 509 BY4741 13_1 3 B 11 YML060W OGG1 - Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA C, F, P DNA metabolic process, hydrolase activity, lyase activity, mitochondrion, response to stress 510 BY4741 13_1 3 B 12 YML059C NTE1 - Serine esterase that deacylates exogenous lysophospholipids, homolog of human neuropathy target esterase (NTE); mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine C, F, P endoplasmic reticulum, hydrolase activity, lipid metabolic process 511 BY4741 13_1 3 C 1 YML058W SML1 - Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase C, F, P cytoplasm, enzyme regulator activity, nucleus, organelle organization and biogenesis, response to stress 512 BY4741 13_1 3 C 2 YML057W CMP2 CNA2 Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 C, F, P cellular homeostasis, conjugation, cytoplasm, hydrolase activity, other, phosphoprotein phosphatase activity, response to chemical stimulus, signal transduction 513 BY4741 13_1 3 C 3 YML058C-A - - - - - 514 BY4741 13_1 3 C 4 YML056C IMD4 - Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed C, F, P biological_process, cytoplasm, oxidoreductase activity 515 BY4741 13_1 3 C 5 YML055W SPC2 SPY1 Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, protein binding, protein modification process, transport 516 BY4741 13_1 3 C 6 YML054C CYB2 - Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions C, F, P cytoplasm, mitochondrial envelope, mitochondrion, other, oxidoreductase activity 517 BY4741 13_1 3 C 7 YML053C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YML053C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus 518 BY4741 13_1 3 C 8 YML052W SUR7 - Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants C, F, P cell cortex, cell wall, membrane, membrane fraction, membrane organization and biogenesis, mitochondrion, molecular_function, plasma membrane, sporulation, transport, vesicle-mediated transport 519 BY4741 13_1 3 C 9 YML051W GAL80 - Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding C, F, P RNA metabolic process, carbohydrate metabolic process, cytoplasm, nucleus, response to chemical stimulus, transcription, transcription regulator activity 520 BY4741 13_1 3 C 10 YML050W - - Putative protein of unknown function; non-essential gene; null mutant displays increased frequency of mitochondrial genome loss (petite formation) C, F, P biological_process, cellular_component, molecular_function 521 BY4741 13_1 3 C 11 YML048W GSF2 ECM6 ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, mitochondrial envelope, mitochondrion, molecular_function, protein folding, transport 523 BY4741 13_1 3 C 12 YML048W-A - - - - - 524 BY4741 13_1 3 D 1 YML037C - - Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene C, F, P biological_process, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function 534 BY4741 13_2 3 D 2 YML035C AMD1 AMD3 AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools C, F, P cytoplasm, hydrolase activity, other 536 BY4741 13_2 3 D 3 YML034W SRC1 HEH1|YML033W Inner nuclear membrane (INM) protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence C, F, P cell cycle, endomembrane system, molecular_function, nucleus, organelle organization and biogenesis 537 BY4741 13_2 3 D 4 YML035C-A - - - - - 538 BY4741 13_2 3 D 5 YML033W - - - - - 539 BY4741 13_2 3 D 6 YML032C RAD52 - Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis C, F, P DNA binding, DNA metabolic process, cell cycle, chromosome, meiosis, nucleus, organelle organization and biogenesis, other, response to stress 540 BY4741 13_2 3 D 7 YML030W - - Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth rate in minimal glycerol media C, F, P biological_process, mitochondrion, molecular_function 543 BY4741 13_2 3 D 8 YML029W USA1 - Protein involved in ER-associated protein degradation (ERAD); component of the Hrd1p complex; interacts with the U1 snRNP-specific protein, Snp1p C, F, P RNA metabolic process, cytoplasm, endomembrane system, endoplasmic reticulum, membrane, molecular_function, protein catabolic process 544 BY4741 13_2 3 D 9 YML028W TSA1 TPX1|ZRG14 Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype C, F, P cellular homeostasis, cytoplasm, other, oxidoreductase activity, protein binding, response to chemical stimulus, response to stress, translation 545 BY4741 13_2 3 D 10 YML026C RPS18B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation 547 BY4741 13_2 3 D 11 YML024W RPS17A RPL51A|RP51A Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein C, F, P cytoplasm, organelle organization and biogenesis, ribosome, ribosome biogenesis, structural molecule activity, translation 549 BY4741 13_2 3 D 12 YML020W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 553 BY4741 13_2 3 E 1 YML019W OST6 - Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, other, protein modification process, transferase activity 554 BY4741 13_2 3 E 2 YML018C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene C, F, P biological_process, cytoplasm, membrane, molecular_function, vacuole 555 BY4741 13_2 3 E 3 YML017W PSP2 MRS15 Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing C, F, P biological_process, cytoplasm, molecular_function 556 BY4741 13_2 3 E 4 YML016C PPZ1 - Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance C, F, P cellular homeostasis, cytoplasm, hydrolase activity, membrane, nucleus, phosphoprotein phosphatase activity, plasma membrane 557 BY4741 13_2 3 E 5 YML014W TRM9 KTI1 tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNAs, creating 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu); deletion confers resistance to zymocin C, F, P RNA metabolic process, cytoplasm, nucleus, response to stress, transferase activity 559 BY4741 13_2 3 E 6 YML013W UBX2 SEL1 Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, mitochondrial envelope, mitochondrion, protein binding, protein catabolic process, transport 560 BY4741 13_2 3 E 7 YML013C-A - - - - - 561 BY4741 13_2 3 E 8 YML012W ERV25 - Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function, transport, vesicle-mediated transport 562 BY4741 13_2 3 E 9 YML011C RAD33 - Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus C, F, P DNA metabolic process, molecular_function, nucleus, response to stress 563 BY4741 13_2 3 E 10 YML009c - - - - - 567 BY4741 13_2 3 E 11 YML008C ERG6 VID1|SED6|LIS1|ISE1 Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane C, F, P cytoplasm, endoplasmic reticulum, lipid metabolic process, membrane, mitochondrial envelope, mitochondrion, transferase activity 568 BY4741 13_2 3 E 12 YML007W YAP1 SNQ3|PAR1 Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium C, F, P DNA binding, RNA metabolic process, cytoplasm, nucleus, response to chemical stimulus, response to stress, transcription, transcription regulator activity 569 BY4741 13_2 3 F 1 YML006C GIS4 - CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway C, F, P cellular homeostasis, molecular_function, plasma membrane, signal transduction 570 BY4741 13_2 3 F 2 YML005W TRM12 TYW2 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA C, F, P RNA metabolic process, cytoplasm, transferase activity 571 BY4741 13_2 3 F 3 YML004C GLO1 - Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress C, F, P cofactor metabolic process, cytoplasm, lyase activity, nucleus, response to chemical stimulus 572 BY4741 13_2 3 F 4 YML003W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 573 BY4741 13_2 3 F 5 YML002W - - Putative protein of unknown function; expression induced by heat and by calcium shortage C, F, P biological_process, cellular_component, molecular_function 574 BY4741 13_2 3 F 6 YML001W YPT7 VAM4|AST4 GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7 C, F, P cytoplasm, hydrolase activity, membrane, membrane organization and biogenesis, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, transport, vacuole, vesicle-mediated transport 575 BY4741 13_2 3 F 7 YMR002W MIC17 - Mitochondrial intermembrane space cysteine motif protein; MIC17 is not an essential gene C, F, P biological_process, cytoplasm, mitochondrial envelope, mitochondrion, molecular_function, nucleus 577 BY4741 13_2 3 F 8 YMR003W - - Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media C, F, P biological_process, mitochondrion, molecular_function 578 BY4741 13_2 3 F 9 YMR006C PLB2 - Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine C, F, P cell wall, extracellular region, hydrolase activity, lipid metabolic process 581 BY4741 13_2 3 F 10 YMR007W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 582 BY4741 13_2 3 F 11 YMR008C PLB1 - Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol C, F, P cell wall, hydrolase activity, lipid metabolic process 583 BY4741 13_2 3 F 12 YMR009W ADI1 - Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions C, F, P amino acid and derivative metabolic process, cytoplasm, nucleus, oxidoreductase activity 584 BY4741 13_2 3 G 1 YMR010W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 C, F, P cytoplasm, molecular_function, other 585 BY4741 13_2 3 G 2 YMR011W HXT2 - High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose C, F, P membrane fraction, plasma membrane, transport, transporter activity 586 BY4741 13_2 3 G 3 YMR012W CLU1 TIF31 eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant C, F, P cytoplasm, molecular_function, organelle organization and biogenesis, translation 587 BY4741 13_2 3 G 4 YMR014W BUD22 - Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern C, F, P anatomical structure morphogenesis, cytokinesis, molecular_function, nucleus, ribosome biogenesis 589 BY4741 13_2 3 G 5 YMR015C ERG5 CYP61 C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs C, F, P endoplasmic reticulum, lipid metabolic process, oxidoreductase activity 590 BY4741 13_2 3 G 6 YMR016C SOK2 - Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors C, F, P DNA binding, nucleus, pseudohyphal growth, transcription regulator activity 591 BY4741 13_2 3 G 7 YMR017W SPO20 DBI9 Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog C, F, P membrane, protein binding, sporulation 592 BY4741 13_2 3 G 8 YMR018W - - Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene C, F, P biological_process, cellular_component, molecular_function 593 BY4741 13_2 3 G 9 YMR019W STB4 - Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters C, F, P DNA binding, biological_process, nucleus 594 BY4741 13_2 3 G 10 YMR020W FMS1 - Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis C, F, P amino acid and derivative metabolic process, cofactor metabolic process, cytoplasm, oxidoreductase activity 595 BY4741 13_2 3 G 11 YMR021C MAC1 CUA1 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport C, F, P RNA metabolic process, cellular homeostasis, nucleus, protein catabolic process, response to chemical stimulus, transcription, transcription regulator activity 596 BY4741 13_2 3 G 12 YMR022W UBC7 QRI8 Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly C, F, P endoplasmic reticulum, ligase activity, organelle organization and biogenesis, protein catabolic process 597 BY4741 13_2 3 H 1 YMR023C MSS1 PET53 Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 C, F, P RNA metabolic process, cytoplasm, membrane, mitochondrial envelope, mitochondrion, other, translation 598 BY4741 13_2 3 H 3 YMR024W MRPL3 - Mitochondrial ribosomal protein of the large subunit C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation 599 BY4741 13_2 3 H 4 YMR025W CSI1 - Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling C, F, P conjugation, molecular_function, nucleus, protein modification process, response to chemical stimulus, signal transduction 600 BY4741 13_2 3 H 5 YMR026C PEX12 PAS11 C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorders C, F, P cytoplasm, membrane, organelle organization and biogenesis, peroxisome, protein binding, transport 601 BY4741 13_2 3 H 6 YMR027W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus 602 BY4741 13_2 3 H 7 YMR029C FAR8 - Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p C, F, P cell cycle, cellular_component, conjugation, molecular_function, response to chemical stimulus 604 BY4741 13_2 3 H 8 YMR030W RSF1 - Protein required for respiratory growth; localized to both the nucleus and mitochondrion; mutant displays decreased transcription of specific nuclear and mitochondrial genes whose products are involved in respiratory growth C, F, P RNA metabolic process, cellular respiration, generation of precursor metabolites and energy, mitochondrion, molecular_function, nucleus, organelle organization and biogenesis, signal transduction, transcription 605 BY4741 13_2 3 H 9 YMR031W-A - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C C, F, P cellular_component, molecular_function, other 606 BY4741 13_2 3 H 10 YMR031C - - Protein of unknown function with similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; YMR031C is not an essential gene C, F, P biological_process, cytoplasm, mitochondrion, molecular_function 607 BY4741 13_2 3 H 11 YMR032W HOF1 CYK2 Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p C, F, P cell cortex, cellular bud, cytokinesis, cytoplasm, cytoskeleton, protein binding, response to stress, site of polarized growth 608 BY4741 13_2 3 H 12 YMR034C - - Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene C, F, P biological_process, cellular_component, transporter activity 610 BY4741 13_2 4 A 1 YMR035W IMP2 - Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p C, F, P cytoplasm, hydrolase activity, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, peptidase activity, protein modification process, transport 611 BY4741 13_2 4 A 2 YMR036C MIH1 - Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25 C, F, P cell cycle, cytoplasm, hydrolase activity, nucleus, phosphoprotein phosphatase activity 612 BY4741 13_2 4 A 3 YMR039C SUB1 TSP1 Transcriptional coactivator, facilitates elongation by influencing enzymes that modify RNAP II, acts in a peroxide resistance pathway involving Rad2p; suppressor of TFIIB mutations C, F, P RNA metabolic process, nucleus, protein binding, transcription, transcription regulator activity 615 BY4741 13_2 4 A 5 YMR040W YET2 - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein C, F, P biological_process, membrane, molecular_function, ribosome 616 BY4741 13_2 4 A 6 YMR041C ARA2 - NAD-dependent arabinose dehydrogenase, involved in biosynthesis of erythroascorbic acid; similar to plant L-galactose dehydrogenase C, F, P cellular_component, oxidoreductase activity, vitamin metabolic process 617 BY4741 13_2 4 A 7 YMR042W ARG80 ARGRI|ARGR1 Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p C, F, P DNA binding, RNA metabolic process, amino acid and derivative metabolic process, nucleus, transcription, transcription regulator activity 618 BY4741 13_2 4 A 8 YMR044W IOC4 - Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif C, F, P nucleus, organelle organization and biogenesis, protein binding 620 BY4741 13_2 4 A 9 YMR140W SIP5 - Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase C, F, P cytoplasm, molecular_function, response to stress 721 BY4741 13_4 4 A 10 YMR141C - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 722 BY4741 13_4 4 A 11 YMR143W RPS16A - Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins C, F, P cytoplasm, nucleolus, nucleus, ribosome, structural molecule activity, translation 724 BY4741 13_4 4 A 12 YMR144W - - Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene C, F, P biological_process, molecular_function, nucleus 725 BY4741 13_4 4 B 1 YMR145C NDE1 NDH1 Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain C, F, P cofactor metabolic process, generation of precursor metabolites and energy, mitochondrion, other, oxidoreductase activity, vitamin metabolic process 726 BY4741 13_4 4 B 2 YMR147W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 728 BY4741 13_4 4 B 3 YMR148W - - Putative protein of unknown function; predicted to contain a transmembrane domain; YMR148W is not an essential gene C, F, P biological_process, membrane, molecular_function 729 BY4741 13_4 4 B 4 YMR151W YIM2 - Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 C, F, P biological_process, cellular_component, molecular_function 731 BY4741 13_4 4 B 5 YMR150C IMP1 PET-TS2858 Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p C, F, P cytoplasm, hydrolase activity, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, peptidase activity, protein modification process, transport 732 BY4741 13_4 4 B 6 YMR152W YIM1 - Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P cytoplasm, mitochondrion, molecular_function, response to stress 733 BY4741 13_4 4 B 7 YMR153W NUP53 - Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex C, F, P endomembrane system, membrane, nuclear organization and biogenesis, nucleus, organelle organization and biogenesis, structural molecule activity, transport 734 BY4741 13_4 4 B 8 YMR153C-A - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53 C, F, P biological_process, cellular_component, molecular_function 735 BY4741 13_4 4 B 9 YMR155W - - Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen C, F, P biological_process, cellular_component, molecular_function 737 BY4741 13_4 4 B 10 YMR156C TPP1 - DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily C, F, P DNA metabolic process, cellular_component, hydrolase activity, response to stress 738 BY4741 13_4 4 B 11 YMR157C - FMP39 Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media C, F, P biological_process, mitochondrion, molecular_function 739 BY4741 13_4 4 B 12 YMR158W-A - - - - - 741 BY4741 13_4 4 C 1 YMR159C ATG16 APG15|APG16|CVT11|SAP18 Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy C, F, P cytoplasm, ligase activity, membrane fraction, protein binding, response to stress 742 BY4741 13_4 4 C 2 YMR161W HLJ1 - Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Hdj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, enzyme regulator activity, membrane, other, protein catabolic process, protein folding 744 BY4741 13_4 4 C 3 YMR162C DNF3 - Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, hydrolase activity, membrane organization and biogenesis, transport, transporter activity 745 BY4741 13_4 4 C 4 YMR163C INP2 - Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene C, F, P cytoplasm, membrane, organelle organization and biogenesis, peroxisome, protein binding 746 BY4741 13_4 4 C 5 YMR164C MSS11 - Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals C, F, P RNA metabolic process, carbohydrate metabolic process, nucleus, pseudohyphal growth, transcription, transcription regulator activity 747 BY4741 13_4 4 C 6 YMR166C - - Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene C, F, P cytoplasm, membrane, mitochondrial envelope, mitochondrion, transport, transporter activity 749 BY4741 13_4 4 C 7 YMR167W MLH1 PMS2 Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer C, F, P DNA binding, DNA metabolic process, cell cycle, cytoplasm, hydrolase activity, meiosis, mitochondrion, nucleus, other, response to stress 750 BY4741 13_4 4 C 8 YMR169C ALD3 - Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose C, F, P amino acid and derivative metabolic process, cytoplasm, oxidoreductase activity, response to stress 752 BY4741 13_4 4 C 9 YMR170C ALD2 - Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p C, F, P amino acid and derivative metabolic process, cytoplasm, other, oxidoreductase activity 753 BY4741 13_4 4 C 10 YMR172C-A - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 756 BY4741 13_4 4 C 11 YMR173W-A - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W C, F, P biological_process, cellular_component, molecular_function 758 BY4741 13_4 4 C 12 YMR174C PAI3 - Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact C, F, P cytoplasm, enzyme regulator activity, protein catabolic process 759 BY4741 13_4 4 D 1 YMR175W SIP18 - Protein of unknown function whose expression is induced by osmotic stress C, F, P lipid binding, other, response to stress 760 BY4741 13_4 4 D 2 YMR176W ECM5 - Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks C, F, P cell wall organization and biogenesis, molecular_function, nucleus 761 BY4741 13_4 4 D 3 YMR177W MMT1 - Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p C, F, P cellular homeostasis, membrane, mitochondrion, molecular_function 762 BY4741 13_4 4 D 4 YMR178W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus 763 BY4741 13_4 4 D 5 YMR179W SPT21 - Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; involved in telomere maintenance C, F, P DNA metabolic process, RNA metabolic process, molecular_function, nucleus, transcription, transposition 764 BY4741 13_4 4 D 6 YMR180C CTL1 CTH1 RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm C, F, P RNA metabolic process, cytoplasm, hydrolase activity, nucleus 765 BY4741 13_4 4 D 7 YMR182C RGM1 - Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth C, F, P RNA metabolic process, nucleus, transcription, transcription regulator activity 767 BY4741 13_4 4 D 8 YMR183C SSO2 - Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p C, F, P cytoplasm, endoplasmic reticulum, membrane, membrane fraction, membrane organization and biogenesis, organelle organization and biogenesis, plasma membrane, protein binding, transport, vesicle-mediated transport 768 BY4741 13_4 4 D 9 YMR184W ADD37 - Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene C, F, P cytoplasm, molecular_function, protein catabolic process 769 BY4741 13_4 4 D 10 YMR186W HSC82 HSP90 Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock C, F, P cytoplasm, hydrolase activity, mitochondrion, organelle organization and biogenesis, other, protein binding, protein folding, response to stress 771 BY4741 13_4 4 D 11 YMR187C - - Putative protein of unknown function; YMR187C is not an essential gene C, F, P biological_process, cellular_component, molecular_function 772 BY4741 13_4 4 D 12 YMR188C MRPS17 - Mitochondrial ribosomal protein of the small subunit C, F, P cellular respiration, cytoplasm, generation of precursor metabolites and energy, mitochondrion, ribosome, structural molecule activity, translation 773 BY4741 13_4 4 E 1 YMR189W GCV2 GSD2 P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm C, F, P amino acid and derivative metabolic process, cytoplasm, mitochondrion, other, oxidoreductase activity 774 BY4741 13_4 4 E 2 YMR190C SGS1 - Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes C, F, P DNA metabolic process, cell cycle, chromosome, helicase activity, hydrolase activity, meiosis, nucleolus, organelle organization and biogenesis, other, response to stress 775 BY4741 13_4 4 E 3 YMR191W SPG5 - Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources C, F, P biological_process, cellular_component, molecular_function 776 BY4741 13_4 4 E 4 YMR192W GYL1 APP2 Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p C, F, P Golgi apparatus, cellular bud, cytoplasm, cytoplasmic membrane-bounded vesicle, mitochondrion, other, plasma membrane, protein binding, site of polarized growth, transport, vesicle-mediated transport 777 BY4741 13_4 4 E 5 YMR193W MRPL24 MRPL14 Mitochondrial ribosomal protein of the large subunit C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation 778 BY4741 13_4 4 E 6 YMR194W RPL36A RPL39B N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA C, F, P RNA binding, cytoplasm, ribosome, structural molecule activity, translation 779 BY4741 13_4 4 E 7 YMR193C-A - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 780 BY4741 13_4 4 E 8 YMR195W ICY1 - Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation C, F, P biological_process, cytoplasm, membrane, molecular_function, vacuole 781 BY4741 13_4 4 E 9 YMR196W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene C, F, P biological_process, cytoplasm, molecular_function 782 BY4741 13_4 4 E 10 YMR198W CIK1 - Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p C, F, P cell cycle, conjugation, cytoplasm, cytoskeleton, cytoskeleton organization and biogenesis, meiosis, microtubule organizing center, motor activity, nuclear organization and biogenesis, organelle organization and biogenesis 784 BY4741 13_4 4 E 11 YMR199W CLN1 - G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) C, F, P cell cycle, cytoplasm, enzyme regulator activity, nucleus 785 BY4741 13_4 4 E 12 YMR201C RAD14 - Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein C, F, P DNA binding, DNA metabolic process, nucleus, organelle organization and biogenesis, other, response to stress 787 BY4741 13_4 4 F 1 YMR202W ERG2 END11 C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis C, F, P endoplasmic reticulum, isomerase activity, lipid metabolic process 788 BY4741 13_4 4 F 2 YMR204C INP1 - Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance C, F, P cytoplasm, membrane, molecular_function, organelle organization and biogenesis, peroxisome 790 BY4741 13_4 4 F 3 YMR205C PFK2 - Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes C, F, P carbohydrate metabolic process, cytoplasm, generation of precursor metabolites and energy, mitochondrion, transferase activity 791 BY4741 13_4 4 F 4 YMR206W - - Putative protein of unknown function; YMR206W is not an essential gene C, F, P biological_process, cellular_component, molecular_function 792 BY4741 13_4 4 F 5 YMR207C HFA1 - Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis C, F, P ligase activity, lipid metabolic process, mitochondrion 793 BY4741 13_4 4 F 6 YMR210W - - Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification C, F, P cellular_component, lipid metabolic process, transferase activity 796 BY4741 13_4 4 F 7 YMR214W SCJ1 - One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins C, F, P cytoplasm, endoplasmic reticulum, protein binding, protein catabolic process, protein folding, response to chemical stimulus, response to stress 800 BY4741 13_4 4 F 8 YMR215W GAS3 - Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall C, F, P biological_process, cell wall, membrane fraction, transferase activity 801 BY4741 13_4 4 F 9 YMR216C SKY1 - SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 C, F, P RNA metabolic process, cellular homeostasis, cytoplasm, other, protein kinase activity, protein modification process, response to chemical stimulus, transferase activity, transport 802 BY4741 13_4 4 F 10 YMR219W ESC1 - Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p C, F, P RNA metabolic process, molecular_function, nucleus, organelle organization and biogenesis, transcription 805 BY4741 13_4 4 F 11 YMR221C - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy C, F, P biological_process, cytoplasm, mitochondrion, molecular_function, vacuole 807 BY4741 13_4 4 F 12 YMR222C FSH2 - Serine hydrolase that localizes to the cytoplasm; sequence is similar to Fsh1p and Fsh3p C, F, P biological_process, cytoplasm, hydrolase activity 808 BY4741 13_4 4 G 1 YMR223W UBP8 - Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B C, F, P hydrolase activity, nucleus, organelle organization and biogenesis, peptidase activity, protein modification process 809 BY4741 13_4 4 G 2 YMR224C MRE11 NGS1|XRS4|RAD58 Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved C, F, P DNA binding, DNA metabolic process, RNA metabolic process, cell cycle, hydrolase activity, meiosis, mitochondrion, nucleus, protein binding, response to stress, sporulation, transcription, transferase activity 810 BY4741 13_4 4 G 3 YMR225C MRPL44 YMR44 Mitochondrial ribosomal protein of the large subunit C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation 811 BY4741 13_4 4 G 4 YMR226C - - NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments C, F, P cytoplasm, nucleus, other, oxidoreductase activity, ribosome 812 BY4741 13_4 4 G 5 YMR228W MTF1 - Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p C, F, P RNA metabolic process, cytoplasm, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, transcription, transcription regulator activity, transferase activity 814 BY4741 13_4 4 G 6 YMR230W RPS10B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10 C, F, P cytoplasm, ribosome, structural molecule activity, translation 816 BY4741 13_4 4 G 7 YMR231W PEP5 VPT11|VPS11|VPL9|VAM1|END1 Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p C, F, P cytoplasm, membrane, membrane organization and biogenesis, molecular_function, organelle organization and biogenesis, transport, vacuole, vesicle-mediated transport 817 BY4741 13_5 4 G 8 YMR232W FUS2 - Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating C, F, P anatomical structure morphogenesis, conjugation, membrane organization and biogenesis, mitochondrion, molecular_function, nucleus, response to chemical stimulus, site of polarized growth 818 BY4741 13_5 4 G 9 YMR233W TRI1 - Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus C, F, P biological_process, cytoplasm, molecular_function, nucleolus, nucleus 819 BY4741 13_5 4 G 10 YMR234W RNH1 - Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201) C, F, P RNA metabolic process, cell wall organization and biogenesis, hydrolase activity, nucleus, other 820 BY4741 13_5 4 G 11 YMR237W BCH1 - Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes C, F, P Golgi apparatus, carbohydrate metabolic process, cell wall organization and biogenesis, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function, ribosome, transport, vesicle-mediated transport 823 BY4741 13_5 4 G 12 YMR238W DFG5 - Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p C, F, P cell budding, cell wall organization and biogenesis, hydrolase activity, membrane, plasma membrane, pseudohyphal growth 824 BY4741 13_5 4 H 1 YMR241W YHM2 - Mitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family C, F, P DNA binding, cytoplasm, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, transport, transporter activity 827 BY4741 13_5 4 H 3 YMR242C RPL20A RPL18A2 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein C, F, P cytoplasm, ribosome, structural molecule activity, translation 828 BY4741 13_5 4 H 4 YMR243C ZRC1 OSR1 Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm C, F, P cellular homeostasis, cofactor metabolic process, cytoplasm, transport, transporter activity, vacuole 829 BY4741 13_5 4 H 5 YMR244W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 830 BY4741 13_5 4 H 6 YMR245W - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 831 BY4741 13_5 4 H 7 YMR244C-A - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus 832 BY4741 13_5 4 H 8 YMR246W FAA4 - Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids C, F, P cytoplasm, ligase activity, lipid metabolic process, protein modification process, transport 833 BY4741 13_5 4 H 9 YMR247C RKR1 - Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential gene C, F, P RNA metabolic process, ligase activity, nucleus, organelle organization and biogenesis, protein modification process, ribosome, transcription 834 BY4741 13_5 4 H 10 YMR250W GAD1 - Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress C, F, P amino acid and derivative metabolic process, cytoplasm, lyase activity, response to chemical stimulus, response to stress 835 BY4741 13_5 4 H 11 YMR251W GTO3 - Omega class glutathione transferase; putative cytosolic localization C, F, P cofactor metabolic process, cytoplasm, transferase activity 836 BY4741 13_5 4 H 12 YMR251W-A HOR7 - Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor C, F, P cell wall, endoplasmic reticulum, membrane fraction, molecular_function, plasma membrane, response to stress 837 BY4741 13_5 5 A 1 YMR252C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene C, F, P biological_process, mitochondrion, molecular_function 838 BY4741 13_5 5 A 2 YMR253C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function 839 BY4741 13_5 5 A 3 YMR254C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 840 BY4741 13_5 5 A 4 YMR255W GFD1 - Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation C, F, P cytoplasm, endomembrane system, membrane, molecular_function, nucleus, transport 841 BY4741 13_5 5 A 6 YMR256C COX7 - Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain C, F, P cytoplasm, generation of precursor metabolites and energy, membrane, mitochondrial envelope, mitochondrion, oxidoreductase activity, transporter activity 842 BY4741 13_5 5 A 7 YMR257C PET111 - Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane C, F, P cytoplasm, membrane, mitochondrial envelope, mitochondrion, translation, translation regulator activity 843 BY4741 13_5 5 A 8 YMR258C - - Protein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus 844 BY4741 13_5 5 A 9 YMR259C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function 845 BY4741 13_5 5 A 10 YMR261C TPS3 - Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway C, F, P carbohydrate metabolic process, cytoplasm, enzyme regulator activity, hydrolase activity, response to stress, transferase activity 847 BY4741 13_5 5 A 11 YMR262W - - Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene C, F, P biological_process, cellular_component, molecular_function 848 BY4741 13_5 5 A 12 YNL047C SLM2 LIT1 Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex C, F, P cytoskeleton organization and biogenesis, lipid binding, organelle organization and biogenesis, other, plasma membrane, signal transduction 7372 BY4741 00_18 5 B 1 YMR264W CUE1 KIS4 Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, mitochondrion, other, protein binding, protein catabolic process 850 BY4741 13_5 5 B 2 YMR265C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function 851 BY4741 13_5 5 B 3 YMR266W RSN1 - Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant C, F, P membrane, molecular_function, transport, vesicle-mediated transport 852 BY4741 13_5 5 B 4 YMR267W PPA2 IPP2 Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate C, F, P cellular respiration, generation of precursor metabolites and energy, hydrolase activity, mitochondrion 853 BY4741 13_5 5 B 5 YMR269W TMA23 YMR268W-A Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes C, F, P molecular_function, nucleolus, organelle organization and biogenesis, ribosome, ribosome biogenesis 855 BY4741 13_5 5 B 6 YMR272C SCS7 FAH1 Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth C, F, P endoplasmic reticulum, lipid metabolic process, membrane, oxidoreductase activity 858 BY4741 13_5 5 B 7 YMR273C ZDS1 OSS1|NRC1|CKM1|CES1 Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of Bcy1p, a regulatory subunit of protein kinase A; implicated in mRNA nuclear export C, F, P RNA metabolic process, anatomical structure morphogenesis, cellular bud, cytoplasm, endomembrane system, membrane, nucleus, organelle organization and biogenesis, other, protein binding, site of polarized growth, transcription, transport 859 BY4741 13_5 5 B 8 YMR274C RCE1 - Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, hydrolase activity, membrane, peptidase activity, protein modification process 860 BY4741 13_5 5 B 9 YMR275C BUL1 SMM2|RDS1|DAG1 Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases C, F, P organelle organization and biogenesis, other, plasma membrane, protein binding, protein modification process 861 BY4741 13_5 5 B 10 YMR276W DSK2 - Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome C, F, P cell cycle, cytoskeleton organization and biogenesis, nucleus, organelle organization and biogenesis, protein binding, protein catabolic process 862 BY4741 13_5 5 B 11 YMR278W PGM3 - Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential C, F, P biological_process, cytoplasm, isomerase activity, nucleus 864 BY4741 13_5 5 B 12 YMR280C CAT8 MSP8|DIL1 Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements C, F, P RNA metabolic process, carbohydrate metabolic process, nucleus, transcription, transcription regulator activity 866 BY4741 13_5 5 C 1 YMR282C AEP2 ATP13 Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader C, F, P mitochondrion, molecular_function, translation 868 BY4741 13_5 5 C 2 YMR283C RIT1 - 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA C, F, P RNA metabolic process, cytoplasm, protein modification process, transferase activity, translation 869 BY4741 13_5 5 C 3 YMR284W YKU70 KU70|NES24|HDF1 Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair C, F, P DNA binding, DNA metabolic process, RNA binding, RNA metabolic process, chromosome, endomembrane system, nucleus, organelle organization and biogenesis, response to stress, transcription 870 BY4741 13_5 5 C 4 YMR285C NGL2 - Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p C, F, P RNA metabolic process, hydrolase activity, organelle organization and biogenesis, other, ribosome biogenesis 871 BY4741 13_5 5 C 5 YMR286W MRPL33 - Mitochondrial ribosomal protein of the large subunit C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation 872 BY4741 13_5 5 C 6 YMR287C DSS1 MSU1 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs C, F, P RNA metabolic process, cytoplasm, hydrolase activity, mitochondrion 873 BY4741 13_5 5 C 7 YMR289W ABZ2 - Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis C, F, P aromatic compound metabolic process, cofactor metabolic process, cytoplasm, heterocycle metabolic process, lyase activity, vitamin metabolic process 875 BY4741 13_5 5 C 8 YMR291W - - Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene C, F, P biological_process, cytoplasm, nucleus, protein kinase activity 878 BY4741 13_5 5 C 9 YMR292W GOT1 - Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2p C, F, P Golgi apparatus, cytoplasm, endomembrane system, membrane, molecular_function, transport, vesicle-mediated transport 879 BY4741 13_5 5 C 10 YMR293C - - Putative protein similar to bacterial glutamyl-tRNA amidotransferases; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) C, F, P cellular respiration, generation of precursor metabolites and energy, hydrolase activity, mitochondrion 880 BY4741 13_5 5 C 11 YMR294W JNM1 PAC3|INS1 Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B C, F, P cytoskeleton, other, structural molecule activity 881 BY4741 13_5 5 C 12 YMR294W-A - - Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents C, F, P biological_process, cellular_component, molecular_function 882 BY4741 13_5 5 D 1 YMR295C - - Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene C, F, P biological_process, cellular bud, molecular_function, ribosome 883 BY4741 13_5 5 D 2 YMR297W PRC1 LBC1 Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family C, F, P cytoplasm, endoplasmic reticulum, hydrolase activity, other, peptidase activity, protein catabolic process, transferase activity, vacuole 885 BY4741 13_5 5 D 3 YMR299C DYN3 - Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration C, F, P cytoskeleton, cytoskeleton organization and biogenesis, motor activity, organelle organization and biogenesis, transport 887 BY4741 13_5 5 D 4 YMR300C ADE4 - Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway C, F, P aromatic compound metabolic process, cytoplasm, heterocycle metabolic process, other, transferase activity 888 BY4741 13_5 5 D 5 YMR302C YME2 PRP12|RNA12 Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases C, F, P Golgi apparatus, cytoplasm, endomembrane system, membrane, mitochondrial envelope, mitochondrion, molecular_function, organelle organization and biogenesis 890 BY4741 13_5 5 D 6 YMR303C ADH2 ADR2 Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 C, F, P amino acid and derivative metabolic process, cofactor metabolic process, cytoplasm, generation of precursor metabolites and energy, other, oxidoreductase activity, vitamin metabolic process 891 BY4741 13_5 5 D 7 YMR304W UBP15 - Ubiquitin-specific protease that may play a role in ubiquitin precursor processing C, F, P cytoplasm, hydrolase activity, peptidase activity, protein modification process 892 BY4741 13_5 5 D 8 YMR304C-A - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10 C, F, P biological_process, cellular_component, molecular_function 893 BY4741 13_5 5 D 9 YMR305C SCW10 - Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p C, F, P cell wall, conjugation, cytoplasm, endoplasmic reticulum, hydrolase activity 894 BY4741 13_5 5 D 10 YMR306C-A - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function 896 BY4741 13_5 5 D 11 YMR307W GAS1 GGP1|CWH52 Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor C, F, P cell wall, cell wall organization and biogenesis, membrane fraction, mitochondrion, other, plasma membrane, transferase activity 897 BY4741 13_5 5 D 12 YMR310C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene C, F, P molecular_function, nucleus, ribosome biogenesis 900 BY4741 13_5 5 E 1 YNL339C YRF1-6 YRF1 Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p C, F, P DNA metabolic process, helicase activity, nucleus, organelle organization and biogenesis 1105 BY4741 14_1 5 E 2 YNL338W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV C, F, P biological_process, cellular_component, molecular_function 1106 BY4741 14_1 5 E 3 YNL336W COS1 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins C, F, P biological_process, cytoplasm, molecular_function, vacuole 1108 BY4741 14_1 5 E 4 YNL335W - - Hypothetical protein C, F, P biological_process, cellular_component, molecular_function 1109 BY4741 14_1 5 E 5 YNL334C SNO2 - Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin C, F, P cellular_component, molecular_function, vitamin metabolic process 1110 BY4741 14_1 5 E 6 YNL333W SNZ2 - Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p C, F, P cellular_component, protein binding, vitamin metabolic process 1111 BY4741 14_1 5 E 7 YNL332W THI12 - Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 C, F, P cellular_component, molecular_function, vitamin metabolic process 1112 BY4741 14_1 5 E 8 YNL330C RPD3 MOF6|SDS6|SDI2|REC3 Histone deacetylase; regulates transcription and silencing; plays a role in regulating Ty1 transposition C, F, P DNA metabolic process, RNA metabolic process, hydrolase activity, nucleus, organelle organization and biogenesis, pro