MAT a Synced to SGD on Fri Aug 1 09:00:52 2008 plate row column ORF Gene Alias Description GO Aspect GO Term Background [00-1] A 1 - - - - - - - [00-1] A 2 YAL064C-A - YAL065C-A Putative protein of unknown function; YAL064C-A is not an essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 [00-1] A 3 - - - - - - - [00-1] A 4 YBL091C-A SCS22 - Protein involved in regulation of phospholipid metabolism; homolog of Scs2p; similar to D. melanogaster inturned protein C, F, P cellular_component, lipid metabolic process, molecular_function BY4742 [00-1] A 5 YBR269C - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function BY4742 [00-1] A 6 - - - - - - - [00-1] A 7 YBR271W - - Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR271W is not as essential gene C, F, P cytoplasm, ribosome biogenesis, transferase activity BY4742 [00-1] A 8 - - - - - - - [00-1] A 9 YBR273C UBX7 CUI3 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p C, F, P endomembrane system, endoplasmic reticulum, molecular_function, nucleus, protein catabolic process, sporulation BY4742 [00-1] A 10 YBR274W CHK1 - Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase C, F, P cell cycle, nucleus, protein kinase activity, protein modification process, response to stress, signal transduction, transferase activity BY4742 [00-1] A 11 - - - - - - - [00-1] A 12 - - - - - - - [00-1] B 1 YBR277C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W C, F, P biological_process, cellular_component, molecular_function BY4742 [00-1] B 2 YBR278W DPB3 - Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle C, F, P DNA metabolic process, RNA metabolic process, chromosome, nucleotidyltransferase activity, nucleus, organelle organization and biogenesis, response to stress, transcription, transferase activity BY4742 [00-1] B 3 YBR279W PAF1 - RNAP II-associated protein; defines large complex biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme; required for full expression of a subset of cell cycle-regulated genes; homolog of human PD2/hPAF1 C, F, P DNA metabolic process, RNA metabolic process, nucleus, organelle organization and biogenesis, protein modification process, transcription, transcription regulator activity, transposition BY4742 [00-1] B 4 - - - - - - - [00-1] B 5 YBR281C DUG2 - Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) C, F, P cofactor metabolic process, cytoplasm, hydrolase activity, nucleus, peptidase activity BY4742 [00-1] B 6 YBR282W MRPL27 - Mitochondrial ribosomal protein of the large subunit C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation BY4742 [00-1] B 7 YBR283C SSH1 - Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, transport, transporter activity BY4742 [00-1] B 8 YBR284W - - Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin and synthetic phenotype with alpha-synuclein C, F, P biological_process, cellular_component, molecular_function BY4742 [00-1] B 9 YBR285W - - Putative protein of unknown function; YBR285W is not an essential gene and deletion of YBR285W leads to poor growth on glucose-minimal medium at 15C C, F, P biological_process, cellular_component, molecular_function BY4742 [00-1] B 10 YBR286W APE3 APY1 Vacuolar aminopeptidase Y, processed to mature form by Prb1p C, F, P cytoplasm, hydrolase activity, peptidase activity, protein catabolic process, vacuole BY4742 [00-1] B 11 - - - - - - - [00-1] B 12 - - - - - - - [00-1] C 1 - - - - - - - [00-1] C 2 YBR290W BSD2 - Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification C, F, P cytoplasm, endoplasmic reticulum, membrane, protein binding, protein catabolic process, transport, vacuole BY4742 [00-1] C 3 YBR291C CTP1 - Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family C, F, P cytoplasm, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, transport, transporter activity BY4742 [00-1] C 4 YBR292C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 [00-1] C 5 YBR293W VBA2 - Permease of basic amino acids in the vacuolar membrane C, F, P cytoplasm, membrane, transport, transporter activity, vacuole BY4742 [00-1] C 6 - - - - - - - [00-1] C 7 YBR295W PCA1 PAY2|CAD2 Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; S288C and most other lab strains contain a G970R mutation which eliminates normal cadmium transport function C, F, P cellular homeostasis, hydrolase activity, other, plasma membrane, transport, transporter activity BY4742 [00-1] C 8 YBR296C PHO89 ITN1 Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p C, F, P plasma membrane, transport, transporter activity BY4742 [00-1] C 9 YBR297W MAL33 MALR|MAL3R MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C C, F, P DNA binding, RNA metabolic process, carbohydrate metabolic process, nucleus, transcription, transcription regulator activity BY4742 [00-1] C 10 YBR298C MAL31 MALT|MAL3T Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C C, F, P membrane fraction, transport, transporter activity BY4742 [00-1] C 11 YBR300C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 [00-1] C 12 - - - - - - - [00-1] D 1 YCL001W-A - - Putative protein of unknown function; YCL001W-A is not an essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 [00-1] D 2 - - - - - - - [00-1] D 3 YCR020W-B HTL1 - Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance C, F, P RNA metabolic process, cell cycle, nucleus, organelle organization and biogenesis, other, response to stress, transcription BY4742 [00-1] D 4 YCR024C SLM5 - Mitochondrial asparaginyl-tRNA synthetase C, F, P ligase activity, mitochondrion, translation BY4742 [00-1] D 5 YCR024C-A PMP1 - Small single-membrane span proteolipid that functions as a regulatory subunit of the plasma membrane H(+)-ATPase Pma1p, forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines C, F, P enzyme regulator activity, membrane, plasma membrane, transport BY4742 [00-1] D 6 YCR025C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 [00-1] D 7 YCR026C NPP1 - Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation C, F, P cellular_component, hydrolase activity, other, response to stress BY4742 [00-1] D 8 YCR027C RHB1 RSG1 Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins C, F, P hydrolase activity, membrane, plasma membrane, transport, vesicle-mediated transport BY4742 [00-1] D 9 YCR028C FEN2 - Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph C, F, P membrane organization and biogenesis, plasma membrane, transport, transporter activity, vesicle-mediated transport BY4742 [00-1] D 10 - - - - - - - [00-1] D 11 - - - - - - - [00-1] D 12 YCR031C RPS14A RPL59|CRY1 Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins C, F, P RNA binding, RNA metabolic process, cytoplasm, nucleolus, nucleus, organelle organization and biogenesis, ribosome, ribosome biogenesis, structural molecule activity, translation BY4742 [00-1] E 1 - - - - - - - [00-1] E 2 - - - - - - - [00-1] E 3 YCR034W FEN1 VBM2|GNS1|ELO2 Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, lipid metabolic process, membrane, transferase activity, vesicle-mediated transport BY4742 [00-1] E 4 - - - - - - - [00-1] E 5 YCR036W RBK1 - Putative ribokinase C, F, P carbohydrate metabolic process, cytoplasm, nucleus, other, transferase activity BY4742 [00-1] E 6 YCR037C PHO87 - Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments C, F, P membrane, transport, transporter activity BY4742 [00-1] E 7 YCR043C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene C, F, P Golgi apparatus, biological_process, molecular_function BY4742 [00-1] E 8 YCR044C PER1 COS16 Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 C, F, P cellular homeostasis, cytoplasm, endoplasmic reticulum, lipid metabolic process, membrane, molecular_function, protein modification process, vacuole BY4742 [00-1] E 9 YCR045C - - Putative protein of unknown function C, F, P biological_process, cellular_component, hydrolase activity, peptidase activity BY4742 [00-1] E 10 - - - - - - - [00-1] E 11 - - - - - - - [00-1] E 12 - - - - - - - [00-1] F 1 YCR049C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-1] F 2 YCR050C - - Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein C, F, P biological_process, cellular_component, molecular_function BY4742 [00-1] F 3 YCR051W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus BY4742 [00-1] F 4 - - - - - - - [00-1] F 5 - - - - - - - [00-1] F 6 - - - - - - - [00-1] F 7 - - - - - - - [00-1] F 8 YCR059C YIH1 - Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene C, F, P amino acid and derivative metabolic process, cytoplasm, molecular_function, nucleus BY4742 [00-1] F 9 - - - - - - - [00-1] F 10 YCR061W - YCR062W Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation C, F, P cytoplasm, molecular_function, other BY4742 [00-1] F 11 - - - - - - - [00-1] F 12 YCR063W BUD31 CWC14 Protein involved in bud-site selection; analysis of integrated high-throughput datasets predicts an involvement in RNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern C, F, P RNA metabolic process, anatomical structure morphogenesis, cytokinesis, molecular_function, nucleus BY4742 [00-1] G 1 - - - - - - - [00-1] G 2 YCR065W HCM1 - Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role C, F, P DNA binding, RNA metabolic process, cell cycle, cytoskeleton organization and biogenesis, nucleus, organelle organization and biogenesis, transcription, transcription regulator activity BY4742 [00-1] G 3 YCR066W RAD18 - Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motif C, F, P DNA binding, DNA metabolic process, chromosome, hydrolase activity, ligase activity, nucleus, response to stress BY4742 [00-1] G 4 - - - - - - - [00-1] G 5 YCR068W ATG15 CVT17|AUT5 Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway C, F, P cytoplasm, hydrolase activity, membrane, membrane organization and biogenesis, other, protein modification process, vacuole BY4742 [00-1] G 6 - - - - - - - [00-1] G 7 YCR071C IMG2 - Mitochondrial ribosomal protein of the small subunit C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation BY4742 [00-1] G 8 - - - - - - - [00-1] G 9 - - - - - - - [00-1] G 10 YCR073W-A SOL2 YCRX13W Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p C, F, P cytoplasm, molecular_function, transport BY4742 [00-1] G 11 - - - - - - - [00-1] G 12 YCR076C - - Putative protein of unknown function; YCR076C is not an essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 [00-1] H 1 YCR077C PAT1 MRT1 Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p C, F, P RNA metabolic process, cytoplasm, molecular_function, other, ribosome, translation BY4742 [00-1] H 2 YCR079W PTC6 PPP2|AUP1 Mitochondrial protein phosphatase of type 2C with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase C, F, P cytoplasm, hydrolase activity, mitochondrial envelope, mitochondrion, other, phosphoprotein phosphatase activity, protein modification process, response to stress BY4742 [00-1] H 3 YCR081W SRB8 MED12|YCR080W|SSN5|NUT6|GIG1 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression C, F, P RNA metabolic process, nucleus, transcription, transcription regulator activity BY4742 [00-1] H 4 YCR082W AHC2 - Protein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleus C, F, P biological_process, cytoplasm, molecular_function, nucleus BY4742 [00-1] H 5 - - - - - - - [00-1] H 6 - - - - - - - [00-1] H 7 YCR085W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-1] H 8 YCR086W CSM1 - Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance C, F, P DNA metabolic process, cell cycle, chromosome, endomembrane system, meiosis, molecular_function, nucleolus, nucleus, response to chemical stimulus BY4742 [00-1] H 9 YCR087C-A - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene C, F, P biological_process, molecular_function, nucleolus BY4742 [00-1] H 10 YCR087W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 [00-1] H 11 - - - - - - - [00-1] H 12 - - - - - - - [00-2] A 1 YCR090C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus BY4742 [00-2] A 2 YCR091W KIN82 - Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily C, F, P cellular_component, protein kinase activity, protein modification process, response to chemical stimulus BY4742 [00-2] A 3 YCR092C MSH3 - Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability C, F, P DNA binding, DNA metabolic process, cell cycle, cytoplasm, meiosis, nucleus, response to stress BY4742 [00-2] A 4 - - - - - - - [00-2] A 5 YCR094W CDC50 - Endosomal protein that regulates cell polarity, controls polarized growth; similar to Ynr048wp and Lem3p C, F, P Golgi apparatus, cell cycle, cytoplasm, hydrolase activity, membrane fraction, membrane organization and biogenesis, other, transport, transporter activity, vesicle-mediated transport BY4742 [00-2] A 6 - - - - - - - [00-2] A 7 YCR098C GIT1 - Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability C, F, P plasma membrane, transport, transporter activity BY4742 [00-2] A 8 YCR099C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] A 9 YCR100C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] A 10 YCR101C - - Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene C, F, P biological_process, membrane fraction, molecular_function BY4742 [00-2] A 11 YCR102C - - Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene C, F, P cellular_component, molecular_function, response to chemical stimulus BY4742 [00-2] A 12 - - - - - - - [00-2] B 1 YCR105W ADH7 ADHVII NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance C, F, P other, oxidoreductase activity BY4742 [00-2] B 2 YCR106W RDS1 - Zinc cluster transcription factor involved in conferring resistance to cycloheximide C, F, P DNA binding, nucleus, response to chemical stimulus, transcription regulator activity BY4742 [00-2] B 3 YDL130W-A STF1 AIS2 Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein C, F, P cytoplasm, membrane, mitochondrial envelope, mitochondrion, molecular_function, other BY4742 [00-2] B 4 - - - - - - - [00-2] B 5 - - - - - - - [00-2] B 6 - - - - - - - [00-2] B 7 - - - - - - - [00-2] B 8 YDR363W-A SEM1 HOD1|DSS1 Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1 C, F, P cell cycle, cytoplasm, membrane fraction, molecular_function, nucleus, other, protein catabolic process, transport, vesicle-mediated transport BY4742 [00-2] B 9 YDR525W-A SNA2 - Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern C, F, P biological_process, cytoplasm, membrane, molecular_function BY4742 [00-2] B 10 YDR535C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] B 11 YDR536W STL1 - Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock C, F, P membrane, plasma membrane, transport, transporter activity BY4742 [00-2] B 12 - - - - - - - [00-2] C 1 YDR538W PAD1 POF1 Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiX C, F, P aromatic compound metabolic process, lyase activity, mitochondrion BY4742 [00-2] C 2 YDR539W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR539W is not an essential gene; homolog of E. coli UbiD C, F, P biological_process, cytoplasm, molecular_function BY4742 [00-2] C 3 YDR540C IRC4 - Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus C, F, P DNA metabolic process, cytoplasm, molecular_function, nucleus BY4742 [00-2] C 4 YDR541C - - Putative dihydrokaempferol 4-reductase C, F, P biological_process, cellular_component, oxidoreductase activity BY4742 [00-2] C 5 - - - - - - - [00-2] C 6 YER039C-A - - Putative protein of unknown function; YER039C-A is not an essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] C 7 - - - - - - - [00-2] C 8 - - - - - - - [00-2] C 9 YER091C-A - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] C 10 YER144C UBP5 - Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck C, F, P cellular bud, hydrolase activity, other, peptidase activity, protein modification process, site of polarized growth BY4742 [00-2] C 11 YER188W - - Hypothetical protein C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] C 12 YFL034C-A RPL22B YFL035C-B Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein C, F, P cytoplasm, ribosome, structural molecule activity, translation BY4742 [00-2] D 1 YFR032C - - Putative protein of unknown function; transcribed during sporulation; YFR032C is not an essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] D 2 YFR032C-A RPL29 - Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate C, F, P cytoplasm, ribosome, structural molecule activity, translation BY4742 [00-2] D 3 YFR033C QCR6 UCR6|COR3 Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1 C, F, P cellular respiration, cytoplasm, generation of precursor metabolites and energy, membrane, mitochondrial envelope, mitochondrion, oxidoreductase activity, transporter activity BY4742 [00-2] D 4 YFR034C PHO4 phoD Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability C, F, P DNA binding, cytoplasm, nucleus, other, response to stress, transcription regulator activity BY4742 [00-2] D 5 YFR035C - - Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] D 6 YFR036W CDC26 SCD26|HIT3 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition C, F, P cell cycle, cytoskeleton organization and biogenesis, ligase activity, nucleus, organelle organization and biogenesis, protein binding, protein catabolic process, protein modification process BY4742 [00-2] D 7 - - - - - - - [00-2] D 8 YFR038W IRC5 - Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci C, F, P DNA metabolic process, cellular_component, molecular_function BY4742 [00-2] D 9 - - - - - - - [00-2] D 10 YFR040W SAP155 - Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p C, F, P cell cycle, cytoplasm, hydrolase activity, phosphoprotein phosphatase activity BY4742 [00-2] D 11 YFR041C ERJ5 - Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response C, F, P endoplasmic reticulum, molecular_function, protein folding BY4742 [00-2] D 12 - - - - - - - [00-2] E 1 YFR043C IRC6 - Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] E 2 YFR044C DUG1 - Probable di- and tri-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) C, F, P cofactor metabolic process, cytoplasm, hydrolase activity, mitochondrion, peptidase activity, ribosome BY4742 [00-2] E 3 YFR045W - - Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white C, F, P cytoplasm, membrane, mitochondrial envelope, mitochondrion, transport, transporter activity BY4742 [00-2] E 4 YFR046C CNN1 - Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1. C, F, P chromosome, molecular_function, nucleus, other BY4742 [00-2] E 5 YFR047C BNA6 QPT1 Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p C, F, P cofactor metabolic process, cytoplasm, nucleus, transferase activity, vitamin metabolic process BY4742 [00-2] E 6 YFR048W RMD8 - Cytosolic protein required for sporulation C, F, P cytoplasm, molecular_function, response to chemical stimulus BY4742 [00-2] E 7 YFR049W YMR31 - Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation BY4742 [00-2] E 8 - - - - - - - [00-2] E 9 - - - - - - - [00-2] E 10 - - - - - - - [00-2] E 11 YFR053C HXK1 - Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p C, F, P carbohydrate metabolic process, cytoplasm, generation of precursor metabolites and energy, transferase activity, transport BY4742 [00-2] E 12 YFR054C - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] F 1 YFR055W IRC7 - Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner C, F, P DNA metabolic process, cellular homeostasis, cellular_component, lyase activity, other BY4742 [00-2] F 2 YFR056C - - Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] F 3 YFR057W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] F 4 YGR219W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] F 5 YGR220C MRPL9 - Mitochondrial ribosomal protein of the large subunit C, F, P cytoplasm, mitochondrion, organelle organization and biogenesis, ribosome, ribosome biogenesis, structural molecule activity, transferase activity, translation BY4742 [00-2] F 6 YGR221C TOS2 - Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p C, F, P cell budding, cellular bud, molecular_function, site of polarized growth BY4742 [00-2] F 7 YGR222W PET54 - Mitochondrial inner membrane protein that binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing C, F, P RNA binding, RNA metabolic process, cytoplasm, membrane, mitochondrial envelope, mitochondrion, translation, translation regulator activity BY4742 [00-2] F 8 YGR223C HSV2 - Phosphatidylinositol 3,5-bisphosphate-binding protein, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization C, F, P biological_process, cytoplasm, lipid binding, vacuole BY4742 [00-2] F 9 YGR224W AZR1 - Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole C, F, P plasma membrane, response to chemical stimulus, transport, transporter activity BY4742 [00-2] F 10 YGR225W AMA1 SPO70 Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis C, F, P cell cycle, cell wall organization and biogenesis, enzyme regulator activity, meiosis, nucleus, protein catabolic process, sporulation BY4742 [00-2] F 11 YGR226C - - Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] F 12 YGR227W DIE2 ALG10 Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, protein modification process, transferase activity BY4742 [00-2] G 1 YGR228W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C C, F, P biological_process, cellular_component, molecular_function BY4742 [00-2] G 2 YGR229C SMI1 KNR4 Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity C, F, P cell cycle, cell wall organization and biogenesis, cellular bud, molecular_function, other, site of polarized growth BY4742 [00-2] G 3 YGR230W BNS1 - Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis C, F, P cellular_component, meiosis, molecular_function BY4742 [00-2] G 4 YGR231C PHB2 - Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation C, F, P cytoplasm, membrane, mitochondrial envelope, mitochondrion, molecular_function, organelle organization and biogenesis, other, protein folding BY4742 [00-2] G 5 YGR232W NAS6 - Regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6 C, F, P molecular_function, other BY4742 [00-2] G 6 YGR233C PHO81 phoS Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p C, F, P cytoplasm, enzyme regulator activity, nucleus, other BY4742 [00-2] G 7 YGR234W YHB1 YHB4 Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses C, F, P cytoplasm, mitochondrion, oxidoreductase activity, response to stress BY4742 [00-2] G 8 YGR235C - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function BY4742 [00-2] G 9 YGR236C SPG1 - Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function BY4742 [00-2] G 10 YGR237C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm C, F, P biological_process, cytoplasm, molecular_function BY4742 [00-2] G 11 - - - - - - - [00-2] G 12 - - - - - - - [00-2] H 1 YGR240C PFK1 - Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes C, F, P carbohydrate metabolic process, cytoplasm, generation of precursor metabolites and energy, mitochondrion, transferase activity BY4742 [00-2] H 2 YGR241C YAP1802 - Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family C, F, P cell cortex, cytoplasm, cytoskeleton, membrane organization and biogenesis, protein binding, transport, vesicle-mediated transport BY4742 [00-2] H 3 YGR242W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C C, F, P biological_process, molecular_function, ribosome BY4742 [00-2] H 4 YGR243W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function BY4742 [00-2] H 5 YGR244C LSC2 - Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate C, F, P cellular respiration, cofactor metabolic process, generation of precursor metabolites and energy, ligase activity, mitochondrion BY4742 [00-2] H 6 - - - - - - - [00-2] H 7 - - - - - - - [00-2] H 8 YGR247W CPD1 - Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression C, F, P cytoplasm, cytoplasmic membrane-bounded vesicle, hydrolase activity, other BY4742 [00-2] H 9 - - - - - - - [00-2] H 10 YGR249W MGA1 - Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants C, F, P DNA binding, nucleus, other, transcription regulator activity BY4742 [00-2] H 11 - - - - - - - [00-2] H 12 - - - - - - - [00-3] A 1 - - - - - - - [00-3] A 2 - - - - - - - [00-3] A 3 - - - - - - - [00-3] A 4 YGR256W GND2 - 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone C, F, P carbohydrate metabolic process, cofactor metabolic process, cytoplasm, oxidoreductase activity, vitamin metabolic process BY4742 [00-3] A 5 - - - - - - - [00-3] A 6 - - - - - - - [00-3] A 7 YGR259C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W C, F, P biological_process, cellular_component, molecular_function BY4742 [00-3] A 8 YGR260W TNA1 - High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) C, F, P membrane, mitochondrion, plasma membrane, transport, transporter activity BY4742 [00-3] A 9 YGR261C APL6 YKS5 Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools C, F, P cytoplasm, membrane, molecular_function, transport, vesicle-mediated transport BY4742 [00-3] A 10 YGR262C BUD32 LDB14 Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p C, F, P RNA metabolic process, anatomical structure morphogenesis, cytokinesis, cytoplasm, nucleus, organelle organization and biogenesis, other, protein kinase activity, protein modification process, transcription, transferase activity BY4742 [00-3] A 11 YGR263C SAY1 - Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum C, F, P cytoplasm, endoplasmic reticulum, hydrolase activity, lipid metabolic process, membrane, response to chemical stimulus BY4742 [00-3] A 12 - - - - - - - [00-3] B 1 - - - - - - - [00-3] B 2 YGR266W - - Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane C, F, P biological_process, cytoplasm, membrane, mitochondrial envelope, mitochondrion, molecular_function, plasma membrane BY4742 [00-3] B 3 - - - - - - - [00-3] B 4 YGR268C HUA1 - Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly C, F, P cytoplasm, cytoskeleton organization and biogenesis, molecular_function, organelle organization and biogenesis BY4742 [00-3] B 5 YGR269W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C C, F, P biological_process, cellular_component, molecular_function BY4742 [00-3] B 6 YGR270W YTA7 - Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p C, F, P hydrolase activity, nucleus, protein catabolic process BY4742 [00-3] B 7 - - - - - - - [00-3] B 8 - - - - - - - [00-3] B 9 - - - - - - - [00-3] B 10 - - - - - - - [00-3] B 11 YGR275W RTT102 - Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition C, F, P RNA metabolic process, molecular_function, nucleus, organelle organization and biogenesis, other, transcription BY4742 [00-3] B 12 - - - - - - - [00-3] C 1 - - - - - - - [00-3] C 2 - - - - - - - [00-3] C 3 YGR279C SCW4 - Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating C, F, P cell wall, conjugation, hydrolase activity BY4742 [00-3] C 4 - - - - - - - [00-3] C 5 YGR281W YOR1 YRS1 Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin C, F, P hydrolase activity, membrane fraction, plasma membrane, response to chemical stimulus, transport, transporter activity BY4742 [00-3] C 6 YGR282C BGL2 - Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance C, F, P cell wall, cell wall organization and biogenesis, hydrolase activity, transferase activity BY4742 [00-3] C 7 YGR283C - - Protein of unknown function; may interact with ribosomes, based on co-purification experiments; deletion mutant is resistant to fluconazole; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus C, F, P molecular_function, nucleolus, ribosome, ribosome biogenesis BY4742 [00-3] C 8 YGR284C ERV29 - Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function, transport, vesicle-mediated transport BY4742 [00-3] C 9 YGR285C ZUO1 - Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p C, F, P cytoplasm, mitochondrion, protein binding, protein folding, ribosome, translation BY4742 [00-3] C 10 YGR286C BIO2 - Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant C, F, P cofactor metabolic process, heterocycle metabolic process, mitochondrion, transferase activity, vitamin metabolic process BY4742 [00-3] C 11 YGR287C - - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies C, F, P biological_process, hydrolase activity, mitochondrion, ribosome BY4742 [00-3] C 12 YGR288W MAL13 MALR MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C C, F, P DNA binding, RNA metabolic process, carbohydrate metabolic process, nucleus, transcription, transcription regulator activity BY4742 [00-3] D 1 - - - - - - - [00-3] D 2 YGR290W - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) C, F, P biological_process, membrane, molecular_function BY4742 [00-3] D 3 - - - - - - - [00-3] D 4 - - - - - - - [00-3] D 5 - - - - - - - [00-3] D 6 - - - - - - - [00-3] D 7 YHR021W-A ECM12 - Non-essential protein of unknown function C, F, P cell wall organization and biogenesis, cellular_component, molecular_function BY4742 [00-3] D 8 YHR039C-B - - - - - BY4742 [00-3] D 9 YHR079C-B - - - - - BY4742 [00-3] D 10 YIL009C-A EST3 - Component of the telomerase holoenzyme, involved in telomere replication C, F, P DNA metabolic process, chromosome, nucleotidyltransferase activity, nucleus, organelle organization and biogenesis, transferase activity BY4742 [00-3] D 11 YIR017C MET28 - Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism C, F, P DNA binding, RNA metabolic process, amino acid and derivative metabolic process, nucleus, other, response to chemical stimulus, transcription, transcription regulator activity BY4742 [00-3] D 12 YIR018W YAP5 - Basic leucine zipper (bZIP) transcription factor C, F, P RNA metabolic process, cell cycle, nucleus, transcription, transcription regulator activity BY4742 [00-3] E 1 YIR019C MUC1 STA4|FLO11 GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) C, F, P molecular_function, other, plasma membrane, pseudohyphal growth BY4742 [00-3] E 2 YIR020C - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-3] E 3 YIR020W-B - - - - - BY4742 [00-3] E 4 YIR021W MRS1 PET157 Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA C, F, P RNA binding, RNA metabolic process, mitochondrion BY4742 [00-3] E 5 - - - - - - - [00-3] E 6 - - - - - - - [00-3] E 7 YIR024C - GIF1 Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect C, F, P biological_process, mitochondrion, molecular_function BY4742 [00-3] E 8 YIR025W MND2 - Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase C, F, P DNA metabolic process, cell cycle, meiosis, molecular_function, nucleus, organelle organization and biogenesis, protein catabolic process, protein modification process BY4742 [00-3] E 9 YIR026C YVH1 - Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; transcription induced by low temperature and nitrogen starvation; member of the dual-specificity family of protein phosphatases C, F, P carbohydrate metabolic process, cytoplasm, generation of precursor metabolites and energy, hydrolase activity, meiosis, phosphoprotein phosphatase activity, ribosome biogenesis, sporulation BY4742 [00-3] E 10 YIR027C DAL1 - Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression C, F, P heterocycle metabolic process, hydrolase activity, other BY4742 [00-3] E 11 YIR028W DAL4 - Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation C, F, P heterocycle metabolic process, membrane, transport, transporter activity BY4742 [00-3] E 12 YIR029W DAL2 ALC1 Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation C, F, P cellular_component, heterocycle metabolic process, hydrolase activity BY4742 [00-3] F 1 - - - - - - - [00-3] F 2 YIR031C DAL7 MSL2|MLS2 Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation C, F, P cellular_component, heterocycle metabolic process, transferase activity BY4742 F 3 - - - - - - - [00-3] F 4 YIR033W MGA2 - ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting C, F, P RNA metabolic process, cytoplasm, endomembrane system, endoplasmic reticulum, lipid metabolic process, membrane, response to stress, transcription, transcription regulator activity BY4742 [00-3] F 5 YIR034C LYS1 - Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway C, F, P amino acid and derivative metabolic process, cytoplasm, oxidoreductase activity BY4742 [00-3] F 6 YIR035C - - Putative cytoplasmic protein of unknown function C, F, P biological_process, cytoplasm, molecular_function BY4742 [00-3] F 7 YIR036C IRC24 - Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci C, F, P biological_process, cytoplasm, molecular_function BY4742 [00-3] F 8 YIR037W HYR1 ORP1|GPX3 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor C, F, P other, oxidoreductase activity, response to chemical stimulus, response to stress BY4742 [00-3] F 9 YIR038C GTT1 - ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p C, F, P cofactor metabolic process, cytoplasm, endoplasmic reticulum, membrane, mitochondrial envelope, mitochondrion, oxidoreductase activity, transferase activity BY4742 [00-3] F 10 YIR039C YPS6 - Putative GPI-anchored aspartic protease C, F, P biological_process, cell wall, hydrolase activity, peptidase activity BY4742 [00-3] F 11 YIR042C - - Putative protein of unknown function; YIR042C is a non-essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 F 12 - - - - - - - G 1 - - - - - - - [00-3] G 2 YKL033W-A - - Putative protein of unknown function; similar to uncharacterized proteins from other fungi C, F, P biological_process, cellular_component, molecular_function BY4742 G 3 - - - - - - - [00-3] G 4 YKL162C-A - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-3] G 5 YKR035W-A DID2 VPS46|CHM1|FTI1 Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors C, F, P cytoplasm, molecular_function, transport, vesicle-mediated transport BY4742 [00-3] G 6 YKR066C CCP1 - Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress C, F, P cytoplasm, mitochondrial envelope, mitochondrion, oxidoreductase activity, response to chemical stimulus, response to stress BY4742 [00-3] G 7 YKR067W GPT2 GAT1 Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis C, F, P cytoplasm, endoplasmic reticulum, lipid metabolic process, transferase activity BY4742 G 8 - - - - - - - [00-3] G 9 YKR069W MET1 MET20 S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis C, F, P amino acid and derivative metabolic process, cofactor metabolic process, heterocycle metabolic process, other, transferase activity BY4742 [00-3] G 10 YKR070W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function BY4742 G 11 - - - - - - - [00-3] G 12 YKR072C SIS2 HAL3 Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression C, F, P cell cycle, cofactor metabolic process, cytoplasm, enzyme regulator activity, lyase activity, nucleus, response to stress BY4742 [00-3] H 1 YKR073C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-3] H 2 YKR074W - - Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation) C, F, P biological_process, cytoplasm, molecular_function BY4742 [00-3] H 3 YKR075C - - Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS C, F, P biological_process, cytoplasm, molecular_function, nucleus BY4742 [00-3] H 4 YKR076W ECM4 GTO2 Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm C, F, P cell wall organization and biogenesis, cofactor metabolic process, cytoplasm, response to chemical stimulus, transferase activity BY4742 [00-3] H 5 YKR077W MSA2 - Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation C, F, P RNA metabolic process, cell cycle, cytoplasm, molecular_function, nucleus, transcription BY4742 [00-3] H 6 YKR078W - - Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) C, F, P cytoplasm, lipid binding, transport, transporter activity BY4742 H 7 - - - - - - - [00-3] H 8 YKR080W MTD1 - NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline C, F, P aromatic compound metabolic process, cofactor metabolic process, cytoplasm, heterocycle metabolic process, other, oxidoreductase activity BY4742 H 9 - - - - - - - [00-3] H 10 YKR082W NUP133 RAT3 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p C, F, P endomembrane system, membrane, nuclear organization and biogenesis, nucleus, organelle organization and biogenesis, other, structural molecule activity, transport BY4742 H 11 - - - - - - - [00-3] H 12 YKR084C HBS1 - GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components C, F, P cytoplasm, molecular_function, translation BY4742 [00-4] A 1 - - - - - - - [00-4] A 2 - - - - - - - [00-4] A 3 YKR087C OMA1 - Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes C, F, P cytoplasm, hydrolase activity, membrane, mitochondrial envelope, mitochondrion, peptidase activity, protein catabolic process BY4742 [00-4] A 4 YKR088C TVP38 - Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern C, F, P Golgi apparatus, cytoplasm, endomembrane system, membrane, molecular_function, vesicle-mediated transport BY4742 [00-4] A 5 YKR089C TGL4 STC1 Triacylglycerol lipase involved in triacylglycerol mobilization and degradation; found in lipid particles; potential Cdc28p substrate C, F, P cytoplasm, hydrolase activity, lipid metabolic process BY4742 [00-4] A 6 YKR090W PXL1 - LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin C, F, P anatomical structure morphogenesis, cellular bud, cytoplasm, other, protein binding, site of polarized growth BY4742 [00-4] A 7 YKR091W SRL3 - Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate C, F, P cytoplasm, molecular_function, other BY4742 [00-4] A 8 YKR092C SRP40 - Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 C, F, P molecular_function, nucleolus, ribosome biogenesis, transport BY4742 [00-4] A 9 YKR093W PTR2 - Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p C, F, P membrane fraction, plasma membrane, transport, transporter activity BY4742 [00-4] A 10 - - - - - - - [00-4] A 11 - - - - - - - [00-4] A 12 - - - - - - - [00-4] B 1 YKR097W PCK1 PPC1|JPM2 Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol C, F, P carbohydrate metabolic process, cytoplasm, lyase activity BY4742 [00-4] B 2 YKR098C UBP11 - Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins C, F, P biological_process, cellular_component, hydrolase activity, peptidase activity BY4742 [00-4] B 3 YKR099W BAS1 - Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes C, F, P DNA binding, DNA metabolic process, RNA metabolic process, amino acid and derivative metabolic process, aromatic compound metabolic process, cell cycle, heterocycle metabolic process, meiosis, nucleus, transcription, transcription regulator activity BY4742 [00-4] B 4 YKR100C SKG1 YKR099C-A Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell C, F, P cell wall organization and biogenesis, cellular bud, molecular_function, other, site of polarized growth BY4742 [00-4] B 5 YKR101W SIR1 - Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin C, F, P DNA binding, RNA metabolic process, nucleus, organelle organization and biogenesis, other, transcription BY4742 [00-4] B 6 - - - - - - - [00-4] B 7 YKR103W NFT1 - Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds. C, F, P hydrolase activity, membrane, transport, transporter activity BY4742 [00-4] B 8 YKR104W - NFT1 Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds C, F, P hydrolase activity, membrane, transport, transporter activity BY4742 [00-4] B 9 YKR105C VBA5 - Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] B 10 YLL018C-A COX19 - Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase C, F, P cytoplasm, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, other, transport BY4742 [00-4] B 11 YLR262C-A TMA7 RBF7 Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin C, F, P cytoplasm, molecular_function, nucleus, translation BY4742 [00-4] B 12 - - - - - - - [00-4] C 1 YLR422W - - Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein C, F, P biological_process, cytoplasm, molecular_function BY4742 [00-4] C 2 YLR423C ATG17 APG17 Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity C, F, P cytoplasm, enzyme regulator activity, organelle organization and biogenesis, other, protein binding, response to stress BY4742 [00-4] C 3 - - - - - - - [00-4] C 4 YLR425W TUS1 SOP10 Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate C, F, P cell wall organization and biogenesis, cellular_component, enzyme regulator activity, signal transduction BY4742 [00-4] C 5 YLR426W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin C, F, P mitochondrion, molecular_function, response to chemical stimulus BY4742 [00-4] C 6 YLR427W MAG2 - Cytoplasmic protein of unknown function predicted to encode a DNA-3-methyladenine glycosidase II that catalyzes the hydrolysis of alkylated DNA C, F, P DNA metabolic process, cytoplasm, molecular_function, response to stress BY4742 [00-4] C 7 YLR428C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] C 8 YLR429W CRN1 - Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly C, F, P cell cortex, cytoplasm, cytoskeleton, cytoskeleton organization and biogenesis, organelle organization and biogenesis, other, protein binding BY4742 [00-4] C 9 - - - - - - - [00-4] C 10 YLR431C ATG23 CVT23 Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p C, F, P cytoplasm, membrane fraction, molecular_function, other, transport BY4742 [00-4] C 11 YLR432W IMD3 - Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed C, F, P cytoplasm, other, oxidoreductase activity BY4742 [00-4] C 12 YLR433C CNA1 CMP1 Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 C, F, P cell wall organization and biogenesis, cellular homeostasis, conjugation, cytoplasm, hydrolase activity, other, phosphoprotein phosphatase activity, response to chemical stimulus, signal transduction BY4742 [00-4] D 1 YLR434C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] D 2 YLR435W TSR2 - Protein with a potential role in pre-rRNA processing C, F, P RNA metabolic process, cytoplasm, molecular_function, nucleus, organelle organization and biogenesis, ribosome biogenesis BY4742 [00-4] D 3 YLR436C ECM30 - Non-essential protein of unknown function C, F, P cell wall organization and biogenesis, cytoplasm, molecular_function BY4742 [00-4] D 4 YLR437C - - Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm C, F, P biological_process, cytoplasm, molecular_function BY4742 [00-4] D 5 - - - - - - - [00-4] D 6 YLR438W CAR2 cargB L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive C, F, P amino acid and derivative metabolic process, cytoplasm, nucleus, transferase activity BY4742 [00-4] D 7 - - - - - - - [00-4] D 8 - - - - - - - [00-4] D 9 YLR441C RPS1A RP10A Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein C, F, P cytoplasm, nucleolus, nucleus, ribosome, structural molecule activity, translation BY4742 [00-4] D 10 - - - - - - - [00-4] D 11 YLR443W ECM7 ZRG15 Non-essential putative integral membrane protein; mutant has cell wall defects; transcription is induced under conditions of zinc deficiency C, F, P cell wall organization and biogenesis, membrane, molecular_function BY4742 [00-4] D 12 YLR444C - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] E 1 YLR445W - - Putative protein of unknown function; transcription is regulated by Ume6p and induced in response to alpha factor C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] E 2 YLR446W - - Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] E 3 YLR447C VMA6 - Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane C, F, P cellular homeostasis, cytoplasm, hydrolase activity, membrane, transport, transporter activity, vacuole BY4742 [00-4] E 4 YLR448W RPL6B - Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA C, F, P RNA binding, cytoplasm, organelle organization and biogenesis, ribosome, ribosome biogenesis, structural molecule activity, translation BY4742 [00-4] E 5 YLR449W FPR4 - Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones C, F, P RNA metabolic process, chromosome, isomerase activity, nucleus, organelle organization and biogenesis, protein binding, protein modification process, ribosome biogenesis, transcription BY4742 [00-4] E 6 YLR450W HMG2 - One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, lipid metabolic process, membrane, mitochondrion, nucleus, oxidoreductase activity BY4742 [00-4] E 7 YLR452C SST2 - GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family C, F, P conjugation, enzyme regulator activity, plasma membrane, response to chemical stimulus, signal transduction BY4742 [00-4] E 8 YLR453C RIF2 - Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation C, F, P DNA binding, DNA metabolic process, chromosome, nucleus, organelle organization and biogenesis BY4742 [00-4] E 9 YLR454W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function BY4742 [00-4] E 10 - - - - - - - [00-4] E 11 YLR456W - - Putative protein of unknown function; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] E 12 - - - - - - - [00-4] F 1 - - - - - - - [00-4] F 2 - - - - - - - [00-4] F 3 YLR460C - - Putative protein of unknown function, possibly up-regulated by iodine C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] F 4 YLR461W PAU4 - Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] F 5 YML009C MRPL39 - Mitochondrial ribosomal protein of the large subunit C, F, P cytoplasm, mitochondrion, ribosome, structural molecule activity, translation BY4742 [00-4] F 6 YML010C-B - - - - - BY4742 [00-4] F 7 YML021C UNG1 - Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus C, F, P DNA metabolic process, hydrolase activity, mitochondrion, nucleus, response to stress BY4742 [00-4] F 8 YML081C-A ATP18 - Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms C, F, P cytoplasm, generation of precursor metabolites and energy, membrane, mitochondrial envelope, mitochondrion, transport, transporter activity BY4742 [00-4] F 9 YMR060C SAM37 TOM37|PET3027|MAS37 Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex; required for the sorting of some proteins to the outer membrane after import by the TOM complex C, F, P cytoplasm, membrane, membrane organization and biogenesis, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, protein binding BY4742 [00-4] F 10 YMR158C-B - - - - - BY4742 [00-4] F 11 YMR169C ALD3 - Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose C, F, P amino acid and derivative metabolic process, cytoplasm, oxidoreductase activity, response to stress BY4742 [00-4] F 12 YMR174C PAI3 - Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact C, F, P cytoplasm, enzyme regulator activity, protein catabolic process BY4742 [00-4] G 1 YMR175W SIP18 - Protein of unknown function whose expression is induced by osmotic stress C, F, P lipid binding, other, response to stress BY4742 [00-4] G 2 YMR194C-A - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] G 3 YMR326C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13 C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] G 4 YNR032C-A HUB1 - Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear C, F, P RNA metabolic process, anatomical structure morphogenesis, conjugation, other, protein modification process, response to chemical stimulus BY4742 [00-4] G 5 YNR050C LYS9 LYS13 Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway C, F, P amino acid and derivative metabolic process, cytoplasm, oxidoreductase activity BY4742 [00-4] G 6 YNR051C BRE5 - Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A C, F, P cytoplasm, molecular_function, other, protein modification process BY4742 [00-4] G 7 - - - - - - - [00-4] G 8 - - - - - - - [00-4] G 9 - - - - - - - [00-4] G 10 - - - - - - - [00-4] G 11 YNR056C BIO5 - Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis C, F, P cofactor metabolic process, heterocycle metabolic process, plasma membrane, transport, transporter activity, vitamin metabolic process BY4742 [00-4] G 12 YNR057C BIO4 - Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels C, F, P cofactor metabolic process, cytoplasm, heterocycle metabolic process, ligase activity, vitamin metabolic process BY4742 [00-4] H 1 YNR058W BIO3 - 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis C, F, P cofactor metabolic process, cytoplasm, heterocycle metabolic process, transferase activity, vitamin metabolic process BY4742 [00-4] H 2 YNR059W MNT4 - Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation C, F, P cellular_component, protein modification process, transferase activity BY4742 [00-4] H 3 YNR060W FRE4 - Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels C, F, P cellular homeostasis, oxidoreductase activity, plasma membrane, transport BY4742 [00-4] H 4 YNR061C - - Putative protein of unknown function C, F, P biological_process, cytoplasm, molecular_function, vacuole BY4742 [00-4] H 5 YNR062C - - Putative membrane protein of unknown function C, F, P biological_process, membrane, molecular_function BY4742 [00-4] H 6 YNR063W - - Putative zinc-cluster protein of unknown function C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] H 7 YNR064C - - Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides C, F, P hydrolase activity, other, response to chemical stimulus BY4742 [00-4] H 8 YNR065C - YSN1 Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] H 9 YNR066C - - Putative membrane-localized protein of unknown function C, F, P biological_process, membrane fraction, molecular_function BY4742 [00-4] H 10 YNR067C DSE4 ENG1 Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother C, F, P cell wall, cytokinesis, extracellular region, hydrolase activity, other BY4742 [00-4] H 11 YNR068C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function BY4742 [00-4] H 12 - - - - - - - [00-5] A 1 - - - - - - - [00-5] A 2 - - - - - - - [00-5] A 3 YER101C AST2 - Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions C, F, P biological_process, cytoplasm, molecular_function BY4742 [00-5] A 4 - - - - - - - [00-5] A 5 YER103W SSA4 YG107 Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation C, F, P cytoplasm, hydrolase activity, nucleus, protein binding, protein folding, response to stress, transport BY4742 [00-5] A 6 - - - - - - - [00-5] A 7 - - - - - - - [00-5] A 8 YER106W MAM1 - Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle C, F, P cell cycle, chromosome, meiosis, molecular_function, nucleus BY4742 [00-5] A 9 - - - - - - - [00-5] A 10 YER108C - - - - - BY4742 [00-5] A 11 YER109C FLO8 YER108C|PHD5 Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene C, F, P RNA metabolic process, cytoplasm, nucleus, other, pseudohyphal growth, transcription, transcription regulator activity BY4742 [00-5] A 12 YER110C KAP123 YRB4 Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 C, F, P cytoplasm, endomembrane system, membrane, nucleus, protein binding, transport, transporter activity BY4742 [00-5] B 1 YER111C SWI4 ART1 DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair C, F, P DNA binding, RNA metabolic process, cell cycle, nucleus, transcription, transcription regulator activity BY4742 [00-5] B 2 - - - - - - - [00-5] B 3 YER113C TMN3 - Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function, other, pseudohyphal growth BY4742 [00-5] B 4 YER114C BOI2 BEB1 Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain C, F, P anatomical structure morphogenesis, cell budding, cellular bud, cytokinesis, lipid binding, signal transduction, site of polarized growth BY4742 [00-5] B 5 YER115C SPR6 - Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation C, F, P cellular_component, molecular_function, sporulation BY4742 [00-5] B 6 YER116C SLX8 - Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate C, F, P ligase activity, organelle organization and biogenesis, other, protein modification process, response to stress BY4742 [00-5] B 7 YER117W RPL23B - Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins C, F, P cytoplasm, response to chemical stimulus, ribosome, structural molecule activity, translation BY4742 [00-5] B 8 YER118C SHO1 SSU81 Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway C, F, P plasma membrane, pseudohyphal growth, response to stress, signal transducer activity, signal transduction, site of polarized growth BY4742 [00-5] B 9 YER119C AVT6 - Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters C, F, P cytoplasm, membrane, transport, transporter activity, vacuole BY4742 [00-5] B 10 YER119C-A - - Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2 C, F, P biological_process, cellular_component, molecular_function BY4742 [00-5] B 11 YER120W SCS2 - Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog C, F, P RNA metabolic process, cytoplasm, endomembrane system, endoplasmic reticulum, lipid binding, lipid metabolic process, membrane, nucleus, organelle organization and biogenesis, protein binding, transcription, transport BY4742 [00-5] B 12 YER121W - - Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy C, F, P biological_process, cellular_component, molecular_function BY4742 [00-5] C 1 YER122C GLO3 - ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, cytoskeleton organization and biogenesis, endomembrane system, enzyme regulator activity, membrane, membrane organization and biogenesis, organelle organization and biogenesis, transport, vesicle-mediated transport BY4742 [00-5] C 2 YER123W YCK3 CKI3 Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of the HOPS complex subunit, Vps41p; shares overlapping essential functions with Hrr25p C, F, P cytoplasm, membrane, nucleus, plasma membrane, protein kinase activity, protein modification process, transferase activity, vacuole BY4742 [00-5] C 3 YER124C DSE1 - Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall C, F, P cellular bud, cytokinesis, molecular_function, site of polarized growth BY4742 [00-5] C 4 - - - - - - - [00-5] C 5 - - - - - - - [00-5] C 6 - - - - - - - [00-5] C 7 YER128W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function BY4742 [00-5] C 8 YER129W SAK1 PAK1 Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome C, F, P DNA metabolic process, carbohydrate metabolic process, cytoplasm, protein kinase activity, protein modification process, transferase activity BY4742 [00-5] C 9 YER130C - - Hypothetical protein C, F, P biological_process, cellular_component, molecular_function BY4742 [00-5] C 10 YER131W RPS26B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein C, F, P cytoplasm, ribosome, structural molecule activity, translation BY4742 [00-5] C 11 YER132C PMD1 - Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions C, F, P cytoplasm, molecular_function, sporulation BY4742 [00-5] C 12 - - - - - - - [00-5] D 1 YER134C - - Putative protein of unknown function; non-essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus BY4742 [00-5] D 2 YER135C - - Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 [00-5] D 3 - - - - - - - [00-5] D 4 YER137C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function BY4742 [00-5] D 5 YER139C RTR1 - Protein with a role in transcription; interacts with Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 shows genetic interactions with RPB4, 5, 7, and 9 C, F, P RNA metabolic process, cytoplasm, molecular_function, nucleus, transcription BY4742 [00-5] D 6 YER140W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function BY4742 [00-5] D 7 YER141W COX15 - Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase C, F, P cofactor metabolic process, cytoplasm, heterocycle metabolic process, membrane, mitochondrial envelope, mitochondrion, oxidoreductase activity BY4742 [00-5] D 8 YER142C MAG1 MMS5 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired C, F, P DNA metabolic process, hydrolase activity, nucleus, response to stress BY4742 [00-5] D 9 YER143W DDI1 VSM1 DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control C, F, P plasma membrane, protein binding, protein catabolic process, vesicle-mediated transport BY4742 [00-5] D 10 YER145C FTR1 - High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron C, F, P cellular homeostasis, membrane, plasma membrane, transport, transporter activity BY4742 [00-5] D 11 - - - - - - - [00-5] D 12 - - - - - - - [00-5] E 1 - - - - - - - [00-5] E 2 YER149C PEA2 PPF2|DFG9 Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth C, F, P anatomical structure morphogenesis, cell budding, cell cortex, conjugation, cytokinesis, cytoplasm, cytoskeleton, cytoskeleton organization and biogenesis, organelle organization and biogenesis, other, protein binding, pseudohyphal growth, response to chemical stimulus, signal transduction, site of polarized growth BY4742 [00-5] E 3 YER150W SPI1 - GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p C, F, P cell wall, molecular_function, response to chemical stimulus BY4742 [00-5] E 4 YER151C UBP3 BLM3 Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin C, F, P cytoplasm, hydrolase activity, other, peptidase activity, protein modification process, response to chemical stimulus BY4742 [00-5] E 5 YER152C - - Putative protein of unknown function; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene C, F, P biological_process, cytoplasm, molecular_function, nucleus BY4742 [00-5] E 6 YER153C PET122 - Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane C, F, P cytoplasm, membrane, mitochondrial envelope, mitochondrion, translation, translation regulator activity BY4742 [00-5] E 7 YER154W OXA1 PET1402 Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals C, F, P cytoplasm, membrane, membrane organization and biogenesis, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, other, transporter activity BY4742 [00-5] E 8 YER155C BEM2 TSL1|SUP9|IPL2 Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence C, F, P anatomical structure morphogenesis, cell budding, cell wall organization and biogenesis, cytoskeleton organization and biogenesis, enzyme regulator activity, mitochondrion, organelle organization and biogenesis, other, signal transduction BY4742 [00-5] E 9 YER156C - - Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus C, F, P biological_process, cytoplasm, molecular_function, nucleus BY4742 [00-5] E 10 - - - - - - - [00-5] E 11 YER158C - - Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p C, F, P biological_process, cellular_component, molecular_function BY4742 [00-5] E 12 - - - - - - - [00-5] F 1 YER161C SPT2 EXA1|SIN1 Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins C, F, P DNA binding, RNA metabolic process, nucleus, organelle organization and biogenesis, transcription BY4742 [00-5] F 2 YER162C RAD4 - Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein C, F, P DNA binding, DNA metabolic process, nucleus, organelle organization and biogenesis, response to stress BY4742 [00-5] F 3 YER163C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus C, F, P biological_process, cytoplasm, molecular_function, nucleus BY4742 [00-5] F 4 YER164W CHD1 - Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes C, F, P RNA metabolic process, hydrolase activity, mitochondrion, nucleus, organelle organization and biogenesis, transcription, transcription regulator activity BY4742 [00-5] F 5 - - - - - - - [00-5] F 6 YER166W DNF1 - Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase C, F, P anatomical structure morphogenesis, hydrolase activity, membrane organization and biogenesis, mitochondrion, plasma membrane, transport, transporter activity, vesicle-mediated transport BY4742 [00-5] F 7 YER167W BCK2 CTR7 Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations C, F, P cell cycle, cytoplasm, molecular_function, nucleus BY4742 [00-5] F 8 - - - - - - - [00-5] F 9 YER169W RPH1 - JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway C, F, P DNA metabolic process, RNA metabolic process, nucleus, organelle organization and biogenesis, other, oxidoreductase activity, protein modification process, response to stress, transcription, transcription regulator activity BY4742 [00-5] F 10 YER170W ADK2 PAK3|AKY3 Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background C, F, P cytoplasm, membrane, mitochondrial envelope, mitochondrion, other, transferase activity BY4742 [00-5] F 11 - - - - - - - [00-5] F 12 - - - - - - - [00-5] G 1 YER173W RAD24 RS1 Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein C, F, P DNA binding, DNA metabolic process, cell cycle, chromosome, hydrolase activity, meiosis, nucleus, response to stress, signal transduction BY4742 [00-5] G 2 YER174C GRX4 - Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage C, F, P cellular homeostasis, nucleus, other, oxidoreductase activity, response to chemical stimulus, response to stress BY4742 [00-5] G 3 YER175C TMT1 TAM1 Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle C, F, P biological_process, cytoplasm, transferase activity BY4742 [00-5] G 4 YER176W ECM32 MTT1|HEL1 DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes C, F, P helicase activity, other, translation BY4742 [00-5] G 5 YER177W BMH1 APR6 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling C, F, P DNA binding, carbohydrate metabolic process, cell cycle, cell wall organization and biogenesis, generation of precursor metabolites and energy, nucleus, protein binding, pseudohyphal growth, response to stress, signal transduction, sporulation BY4742 [00-5] G 6 YER178W PDA1 - E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose C, F, P cytoplasm, mitochondrion, other, oxidoreductase activity BY4742 [00-5] G 7 YER179W DMC1 ISC2 Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein C, F, P DNA binding, DNA metabolic process, cell cycle, chromosome, meiosis, nucleus BY4742 [00-5] G 8 YER180C ISC10 - Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells C, F, P cellular_component, molecular_function, sporulation BY4742 [00-5] G 9 YER181C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function BY4742 [00-5] G 10 YER182W - - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P biological_process, mitochondrion, molecular_function BY4742 [00-5] G 11 YER183C FAU1 - 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis C, F, P aromatic compound metabolic process, cofactor metabolic process, heterocycle metabolic process, ligase activity, mitochondrion BY4742 [00-5] G 12 YER184C - - Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source C, F, P biological_process, cellular_component, molecular_function BY4742 [00-5] H 1 YER185W PUG1 - Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions C, F, P membrane, molecular_function, plasma membrane, transport BY4742 [00-5] H 2 YER186C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function BY4742 [00-5] H 3 YER187W - - Putative protein of unknown function; induced in respiratory-deficient cells C, F, P biological_process, cellular_component, molecular_function BY4742 [00-5] H 4 - - - - - - - [00-5] H 5 YMR052C-A - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-5] H 6 YMR052W FAR3 - Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p C, F, P cell cycle, conjugation, endoplasmic reticulum, molecular_function, response to chemical stimulus BY4742 [00-5] H 7 YMR053C STB2 - Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p C, F, P nucleus, organelle organization and biogenesis, protein modification process, transcription regulator activity BY4742 [00-5] H 8 YMR054W STV1 - Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole C, F, P Golgi apparatus, cellular homeostasis, cytoplasm, hydrolase activity, membrane, transporter activity, vacuole BY4742 [00-5] H 9 YMR055C BUB2 PAC7 Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage C, F, P cell cycle, cytoplasm, cytoskeleton, enzyme regulator activity, microtubule organizing center BY4742 [00-5] H 10 YMR056C AAC1 - Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator C, F, P cellular respiration, cytoplasm, generation of precursor metabolites and energy, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, transport, transporter activity BY4742 [00-5] H 11 YMR057C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1 C, F, P biological_process, cellular_component, molecular_function BY4742 [00-5] H 12 YMR058W FET3 - Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases C, F, P cellular homeostasis, membrane, oxidoreductase activity, plasma membrane, response to chemical stimulus, transport, transporter activity BY4742 [00-6] A 1 - - - - - - - [00-6] A 2 - - - - - - - [00-6] A 3 YMR062C ECM40 ARG7 Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine C, F, P amino acid and derivative metabolic process, cell wall organization and biogenesis, cytoplasm, mitochondrion, transferase activity BY4742 [00-6] A 4 YMR063W RIM9 - Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein C, F, P cellular_component, molecular_function, sporulation BY4742 [00-6] A 5 YMR064W AEP1 NCA1 Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase C, F, P mitochondrion, molecular_function, translation BY4742 [00-6] A 6 YMR065W KAR5 FIG3 Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone C, F, P conjugation, cytoplasm, endomembrane system, endoplasmic reticulum, membrane, mitochondrion, molecular_function, nuclear organization and biogenesis, organelle organization and biogenesis BY4742 [00-6] A 7 YMR066W SOV1 - Mitochondrial protein of unknown function C, F, P biological_process, mitochondrion, molecular_function BY4742 [00-6] A 8 YMR067C UBX4 CUI1 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p C, F, P cytoplasm, molecular_function, nucleus, protein catabolic process, sporulation BY4742 [00-6] A 9 YMR068W AVO2 - Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth C, F, P cell wall organization and biogenesis, cytoplasm, cytoskeleton organization and biogenesis, molecular_function, organelle organization and biogenesis, other, signal transduction BY4742 [00-6] A 10 YMR069W NAT4 - N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A C, F, P cytoplasm, nucleus, organelle organization and biogenesis, protein modification process, transferase activity BY4742 [00-6] A 11 YMR070W MOT3 ROX7 Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes C, F, P DNA binding, RNA metabolic process, nucleus, transcription, transcription regulator activity BY4742 [00-6] A 12 YMR071C TVP18 - Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments C, F, P Golgi apparatus, cytoplasm, cytoplasmic membrane-bounded vesicle, endomembrane system, membrane, molecular_function, vesicle-mediated transport BY4742 [00-6] B 1 YMR072W ABF2 - Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation C, F, P DNA binding, chromosome, cytoplasm, mitochondrion, organelle organization and biogenesis BY4742 [00-6] B 2 YMR073C IRC21 - Putative protein of unknown function; proposed to be involved in resistance to carboplatin and cisplatin; shares similarity to a human cytochrome oxidoreductase; null mutant displays increased levels of spontaneous Rad52p foci C, F, P cytoplasm, molecular_function, response to chemical stimulus BY4742 [00-6] B 3 - - - - - - - [00-6] B 4 YMR075C-A - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W C, F, P biological_process, cellular_component, molecular_function BY4742 [00-6] B 5 YMR075W RCO1 - Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p C, F, P hydrolase activity, nucleus, organelle organization and biogenesis, protein modification process BY4742 [00-6] B 6 - - - - - - - [00-6] B 7 YMR077C VPS20 VPL10|VPT20|CHM6 Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes C, F, P cytoplasm, membrane, protein binding, protein catabolic process, transport, vesicle-mediated transport BY4742 [00-6] B 8 YMR078C CTF18 CHL12 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint C, F, P cell cycle, chromosome, mitochondrion, molecular_function, nucleus, organelle organization and biogenesis BY4742 [00-6] B 9 - - - - - - - [00-6] B 10 YMR080C NAM7 UPF1|MOF4|IFS2 ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance C, F, P RNA metabolic process, cytoplasm, helicase activity, hydrolase activity, organelle organization and biogenesis, other, transcription, translation BY4742 [00-6] B 11 YMR081C ISF1 MBR3 Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant C, F, P cellular respiration, cellular_component, generation of precursor metabolites and energy, molecular_function BY4742 [00-6] B 12 YMR082C - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-6] C 1 YMR083W ADH3 - Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production C, F, P amino acid and derivative metabolic process, cofactor metabolic process, cytoplasm, generation of precursor metabolites and energy, mitochondrion, other, oxidoreductase activity, vitamin metabolic process BY4742 [00-6] C 2 YMR084W - - Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains C, F, P biological_process, cellular_component, molecular_function BY4742 [00-6] C 3 YMR085W - - Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains C, F, P biological_process, cellular_component, molecular_function BY4742 [00-6] C 4 YMR086C-A - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-6] C 5 YMR086W - - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; cAMP represses YMR086W expression C, F, P biological_process, cytoplasm, molecular_function, ribosome BY4742 [00-6] C 6 YMR087W - - Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain C, F, P RNA metabolic process, cellular_component, hydrolase activity BY4742 [00-6] C 7 YMR088C VBA1 - Permease of basic amino acids in the vacuolar membrane C, F, P cytoplasm, membrane, transport, transporter activity, vacuole BY4742 [00-6] C 8 YMR089C YTA12 RCA1 Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes C, F, P cytoplasm, hydrolase activity, membrane, mitochondrial envelope, mitochondrion, organelle organization and biogenesis, other, peptidase activity, protein modification process, transport BY4742 [00-6] C 9 YMR090W - - Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene C, F, P biological_process, cytoplasm, molecular_function BY4742 [00-6] C 10 YMR091C NPL6 RSC7 Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length C, F, P RNA metabolic process, hydrolase activity, nucleus, organelle organization and biogenesis, response to stress, transcription, transport BY4742 [00-6] C 11 YMR092C AIP1 - Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats C, F, P cell cortex, cytoplasm, cytoskeleton, cytoskeleton organization and biogenesis, nucleus, organelle organization and biogenesis, protein binding, response to stress BY4742 [00-6] C 12 - - - - - - - [00-6] D 1 YNR070W - PDR18 Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies C, F, P hydrolase activity, membrane, mitochondrion, transport, transporter activity BY4742 [00-6] D 2 YNR071C - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function BY4742 [00-6] D 3 YNR072W HXT17 - Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose C, F, P plasma membrane, transport, transporter activity BY4742 [00-6] D 4 YNR073C - - Putative mannitol dehydrogenase C, F, P biological_process, cellular_component, oxidoreductase activity BY4742 [00-6] D 5 YNR074C AIF1 CPD1 Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase C, F, P mitochondrion, nucleus, other, oxidoreductase activity, plasma membrane, response to chemical stimulus, response to stress BY4742 [00-6] D 6 YNR075W COS10 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane organization and biogenesis, molecular_function, nucleus, transport, vesicle-mediated transport BY4742 [00-6] D 7 YOL013W-A - YOL013W-B Putative protein of unknown function; identified by SAGE C, F, P biological_process, cellular_component, molecular_function BY4742 [00-6] D 8 YOL086C ADH1 ADC1 Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway C, F, P amino acid and derivative metabolic process, cofactor metabolic process, cytoplasm, generation of precursor metabolites and energy, oxidoreductase activity, vitamin metabolic process BY4742 - [00-6] D 9 YOL087C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid C, F, P biological_process, cytoplasm, molecular_function BY4742 [00-6] D 10 YOL088C MPD2 - Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p C, F, P endoplasmic reticulum, isomerase activity, oxidoreductase activity, protein folding BY4742 [00-6] D 11 YOL089C HAL9 - Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression C, F, P RNA metabolic process, mitochondrion, nucleus, response to stress, transcription, transcription regulator activity BY4742 [00-6] D 12 YOL090W MSH2 PMS5 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP C, F, P DNA binding, DNA metabolic process, RNA metabolic process, cell cycle, chromosome, hydrolase activity, meiosis, nucleus, organelle organization and biogenesis, other, response to stress, transcription BY4742 [00-6] E 1 YOL091W SPO21 MPC70 Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation C, F, P cell wall organization and biogenesis, cytoplasm, cytoskeleton, meiosis, microtubule organizing center, sporulation, structural molecule activity BY4742 [00-6] E 2 YOL092W - - Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W; deletion mutant has no detectable phenotype C, F, P biological_process, cytoplasm, membrane, molecular_function, vacuole BY4742 [00-6] E 3 YOL093W TRM10 - tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs C, F, P RNA metabolic process, cytoplasm, nucleus, transferase activity BY4742 [00-6] E 4 - - - - - - - [00-6] E 5 YOL095C HMI1 - Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD C, F, P DNA metabolic process, cytoplasm, helicase activity, hydrolase activity, mitochondrion, organelle organization and biogenesis BY4742 [00-6] E 6 YOL096C COQ3 - O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex C, F, P cofactor metabolic process, cytoplasm, membrane, mitochondrial envelope, mitochondrion, transferase activity BY4742 [00-6] E 7 - - - - - - - [00-6] E 8 YOL098C - - Putative metalloprotease C, F, P biological_process, cytoplasm, molecular_function BY4742 [00-6] E 9 YOL099C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes C, F, P biological_process, molecular_function, ribosome BY4742 [00-6] E 10 YOL100W PKH2 - Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p C, F, P cell wall organization and biogenesis, nucleus, protein kinase activity, protein modification process, signal transduction BY4742 [00-6] E 11 YOL101C IZH4 - Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism C, F, P cellular homeostasis, lipid metabolic process, membrane, other BY4742 [00-6] E 12 - - - - - - - [00-6] F 1 YOL103W ITR2 HRB612 Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively C, F, P membrane, plasma membrane, transport, transporter activity BY4742 [00-6] F 2 YOL104C NDJ1 TAM1 Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes C, F, P DNA binding, DNA metabolic process, cell cycle, chromosome, meiosis, nucleus, organelle organization and biogenesis BY4742 [00-6] F 3 YOL105C WSC3 - Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis C, F, P cell wall organization and biogenesis, cytoskeleton organization and biogenesis, membrane fraction, organelle organization and biogenesis, response to stress, signal transducer activity, signal transduction BY4742 [00-6] F 4 YOL106W - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-6] F 5 YOL107W - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein C, F, P Golgi apparatus, biological_process, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function BY4742 [00-6] F 6 YOL108C INO4 - Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain C, F, P DNA binding, RNA metabolic process, lipid metabolic process, nucleus, transcription, transcription regulator activity BY4742 [00-6] F 7 YOL109W ZEO1 - Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria C, F, P cell wall organization and biogenesis, cytoplasm, membrane, mitochondrial envelope, mitochondrion, molecular_function, plasma membrane, response to stress BY4742 [00-6] F 8 YOL110W SHR5 ERF4 Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization C, F, P cytoplasm, endomembrane system, endoplasmic reticulum, membrane, other, protein modification process, signal transduction, transferase activity BY4742 [00-6] F 9 YOL111C MDY2 TMA24 Protein required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes and interacts with YOR164C; contains a ubiquitin-like (UBL) domain C, F, P anatomical structure morphogenesis, conjugation, cytoplasm, molecular_function, nucleus, response to chemical stimulus, ribosome BY4742 [00-6] F 10 YOL112W MSB4 - GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization C, F, P cellular bud, cytoskeleton organization and biogenesis, enzyme regulator activity, organelle organization and biogenesis, other, site of polarized growth BY4742 [00-6] F 11 YOL113W SKM1 - Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; proposed to be a downstream effector of Cdc42p during polarized growth C, F, P cell cycle, cytokinesis, plasma membrane, protein kinase activity, protein modification process, transferase activity BY4742 [00-6] F 12 YOL114C - - Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene C, F, P biological_process, cellular_component, molecular_function BY4742 [00-6] G 1 YOL115W PAP2 TRF4 Catalytic subunit of TRAMP, a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; has 5'-dRP lyase activity; disputed role as a DNA polymerase C, F, P DNA metabolic process, RNA metabolic process, cell cycle, lyase activity, nucleotidyltransferase activity, nucleus, organelle organization and biogenesis, other, transferase activity BY4742 [00-6] G 2 YOL116W MSN1 PHD2|MSS10|HRB382|FUP1 Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus C, F, P nucleus, other, response to stress, transcription regulator activity BY4742 [00-6] G 3 YOL117W RRI2 CSN10 Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response C, F, P conjugation, molecular_function, nucleus, protein modification process, response to chemical stimulus, signal transduction BY4742 [00-6] G 4 YOL118C - - Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-6] G 5 YOL119C MCH4 - Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport C, F, P cytoplasm, membrane, transport, transporter activity, vacuole BY4742 [00-6] G 6 - - - - - - - [00-6] G 7 YOL121C RPS19A - Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp C, F, P RNA metabolic process, cytoplasm, organelle organization and biogenesis, ribosome, ribosome biogenesis, structural molecule activity, translation, transport BY4742 [00-6] G 8 YOL122C SMF1 SBS1 Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins C, F, P cytoplasm, plasma membrane, transport, transporter activity, vacuole BY4742 [00-6] G 9 - - - - - - - [00-6] G 10 YOL124C TRM11 - Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain C, F, P RNA binding, RNA metabolic process, cytoplasm, ribosome biogenesis, transferase activity BY4742 [00-6] G 11 - - - - - - - [00-6] G 12 YOL126C MDH2 - Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1 C, F, P carbohydrate metabolic process, cytoplasm, other, oxidoreductase activity BY4742 [00-6] H 1 - - - - - - - [00-6] H 2 YOL128C YGK3 - Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation C, F, P cellular_component, other, protein kinase activity, protein modification process, response to stress, transferase activity BY4742 [00-6] H 3 YOL129W VPS68 - Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria C, F, P cytoplasm, membrane, mitochondrion, molecular_function, transport, vacuole, vesicle-mediated transport BY4742 [00-6] H 4 - - - - - - - [00-6] H 5 YOL131W - - Putative protein of unknown function C, F, P biological_process, cellular_component, molecular_function BY4742 [00-6] H 6 YOL132W GAS4 - 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall C, F, P cell wall, cell wall organization and biogenesis, sporulation, transferase activity BY4742 [00-6] H 7 - - - - - - - [00-6] H 8 - - - - - - - [00-6] H 9 - - - - - - - [00-6] H 10 YOL136C PFK27 - 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A C, F, P carbohydrate metabolic process, cytoplasm, generation of precursor metabolites and energy, transferase activity BY4742 [00-6] H 11 YOL137W BSC6 - Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression C, F, P Golgi apparatus, biological_process, cytoplasm, cytoplasmic membrane-bounded vesicle, molecular_function BY4742 [00-6] H 12 YOL138C - - Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; null mutation suppresses cdc13-1 temperature sensitivity C, F, P biological_process, cytoplasm, molecular_function, ribosome, vacuole BY4742 [00-8] A 1 YBR232C - - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data C, F, P biological_process, cellular_component, molecular_function BY4742 [00-8] A 2 - - - - - - - [00-8] A 3 YDR424C DYN2 SLC1 Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex C, F, P cytoskeleton, cytoskeleton organization and biogenesis, endomembrane system, membrane, motor activity, nuclear organization and biogenesis, nucleus, organelle organization and biogenesis, peroxisome BY4742 [00-8] A 4 YEL011W GLC3 GHA1 Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern C, F, P carbohydrate metabolic process, cytoplasm, generation of precursor metabolites and energy, transferase activity BY4742 [00-8] A 5 - - - - - - - [00-8] A 6 YER064C - - Non-essential nuclear protein; null mutation has global effects on transcription C, F, P molecular_function, nucleus, transcription BY4742 [00-8] A 7 YER077C - - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion C, F, P biological_process, mitochondrion, molecular_function BY4742 [00-8] A 8 YER078C - - Putative mitochondrial metallopeptidase C, F, P biological_process, hydrolase activity, mitochondrion, peptidase activity BY4742 [00-8] A 9 YER088C DOT6 - Protein of unknown function, involved in telomeric gene silencing and filamentation C, F, P RNA metabolic process, cytoplasm, molecular_function, nucleus, organelle organization and biogenesis, other, transcription BY4742 [